Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk

Abstract

Background: Number of studies have been performed to investigate the relationship between the CYP1A1 rs4646903 polymorphism and male infertility risk, but the sample size was small and the results were conflicting. A meta-analysis was performed to assess these associations. Methods: A systematic search was conducted to identify all relevant studies from Medline, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), WanFang and Weipu (VIP) databases up to June 30, 2018. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations. All of the statistical analyses were conducted using Revman 5.3 and Stata 14.0. Results: Ten studies involved 3028 cases and 3258 controls. Overall, significant association was observed between the CYP1A1 rs4646903 polymorphism and male infertility (C vs T: OR = 1.42, 95%CI = 1.14–1.76; CC vs TT: OR = 2.13, 95%CI = 1.36–3.34; CC vs CT+TT: OR = 1.96, 95%CI = 1.30–2.95; CC+CT vs TT: OR = 1.51, 95%CI = 1.16–1.97). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (C vs T: OR = 1.59, 95%CI = 1.22–2.08), but not in Non-Asians (C vs T: OR = 1.01, 95%CI = 0.79–1.30). Additionally, none of the individual studies significantly affected the association between CYP1A1 rs4646903 polymorphism and male infertility, according to sensitivity analysis. Conclusion: Our meta-analysis supports that the CYP1A1 rs4646903 polymorphism might contribute to individual susceptibility to male infertility in Asians.

Lack of Association between CYP1A1 3801T > C Polymorphism and Idiopathic Male Infertility in Algerian Population

“…Nejati et al [21] have conducted a meta-analysis and have indicated that, CYP1A1 3801T > C transition can be considered as a biomarker for risk of male infertility within Asian populations. Cao et al [22] have similarly investigated the relationship between the studied polymorphism and male infertility risk and came to the conclusion that this variant can play a role in individual susceptibility to male infertility in Asians.…”

Effectiveness of Pharmacological Intervention Among Men with Infertility: A Systematic Review and Network Meta-Analysis

“…Inability to achieve clinical conception despite 1 year of unprotected intercourse with the same partner is categorized as human infertility by the World Health Organization (WHO) (Zhao et al, 2016;Buhling et al, 2019;Cao et al, 2019;Hosseini et al, 2019;Wang et al, 2020). A total of 15% (48.5 million) couples worldwide are affected by any kind of infertility, and male infertility dominates the trend with 70% of all cases.…”

“…A total of 15% (48.5 million) couples worldwide are affected by any kind of infertility, and male infertility dominates the trend with 70% of all cases. Higher male infertility rates are seen in the population of Central Europe, Eastern Europe, and Africa (Zhao et al, 2016;Buhling et al, 2019;Cao et al, 2019;Hosseini et al, 2019;Wang et al, 2020).…”

“…Concentration, morphology, and motility are three primary endpoints to assess the sperm quality (Buhling et al, 2019). Other factors include genetics (chromosomal aberrations, gene mutations, congenital anomalies, and polymorphisms), morphology of the reproductive system (testicular cancer, aplasia of the germinal cells, alteration in reproductive hormone, varicocele, defects in the transport of sperm, and bilateral sperm ducts), addictive disorders (alcoholism, smoking, and drug addiction), environmental factors (cigarette, smoking, exposure to certain chemicals, and nutritional deficiency), and alteration in spermatogenesis due to pathophysiological conditions (infectious diseases, pregnancyrelated infections, urogenital infections, genitourinary dysplasia, immune system-related factor, abnormal levels of biochemical components of seminal plasma, and presence of antiserum antibodies (ASAs)) (Zhao et al, 2016;Buhling et al, 2019;Cao et al, 2019;Hosseini et al, 2019;Wang et al, 2020).…”

Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis: Erratum

“…In the article, “Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis”, [1] which appears in Volume 98, Issue 31 of Medicine Dr. DongLiang Lu's degree should appear as MD and affiliation a. Dr. Qiang Wei's degree should appear as MD.…”