Association between culture and the preference for, and perceptions of, 11 routes of medicine administration: A survey in 21 countries and regions

Murdan, Sudaxshina; Wei, Li; van Riet-Nales, Diana A.; Gurmu, Abyot Endale; Usifoh, Stella Folajole; Tăerel, Adriana-Elena; Yıldız-Peköz, Ayca; Krajnović, Dušanka; Azzopardi, Lilian M.; Brock, Tina; Fernandes, Ana I.; dos Santos, André Luis Souza; Anto, Berko Panyin; Vallet, Thibault; Lee, Eunkyung Euni; Jeong, Kyeong Hye; Akel, Marwan; Tam, Eliza; Volmer, Daisy; Douss, Tawfik; Shukla, Sharvari; Yamamura, Shigeo; Lou, Xiaoe; van Riet, Bauke H.G.; Usifoh, Cyril O.; Duwiejua, Mahama; Ruiz, Fabrice; Furnham, Adrian

doi:10.1016/j.rcsop.2023.100378

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Oral drug administration is the intake route preferred by patients and healthcare providers [ 1 ]. Oral delivery is non-invasive, painless, easy to perform, and can be self-administered [ 2 ]. Over the years, various NPs have been used as oral DDSs, such as polymeric NPs [ 3 , 4 ], liposomes [ 5 ], membrane-based NPs [ 6 ], nano-sized hydrogels [ 7 ], and recently biomimetic NPs derived from edible plants (e.g., corn [ 8 ], grapefruit [ 9 ], and ginger [ 10 ]).…”

Section: Introductionmentioning

confidence: 99%

Algae-Based Nanoparticles for Oral Drug Delivery Systems

Drori,

Patel,

Coopersmith

et al. 2024

Marine Drugs

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Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage as oral DDSs by measuring their size, surface charge, morphology, encapsulation efficiency, mucoadhesion force, and cellular uptake into Caco-2 cells. The NPs composed of algal materials (aNPs) exhibited a spherical morphology with a size range of 126–606 nm and a surface charge of −9 to −38 mV. The mucoadhesive forces tested ex vivo against mice, pigs, and sheep intestines revealed significant variation between algae and animal models. Notably, Arthospira platensis (i.e., Spirulina) NPs (126 ± 2 nm, −38 ± 3 mV) consistently exhibited the highest mucoadhesive forces (up to 3127 ± 272 µN/mm²). Moreover, a correlation was found between high mucoadhesive force and high cellular uptake into Caco-2 cells, further supporting the potential of aNPs by indicating their ability to facilitate drug absorption into the human intestinal epithelium. The results presented herein serve as a proof of concept for the possibility of aNPs as oral drug delivery vehicles.

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Section: Introductionmentioning

confidence: 99%

Algae-Based Nanoparticles for Oral Drug Delivery Systems

Drori,

Patel,

Coopersmith

et al. 2024

Marine Drugs

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Schizophrenic patient’s preference for long-acting injectable antipsychotics in Saudi Arabia

Aljumah,

Al-Zaagi,

Almutairi

et al. 2024

JMAHS

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Objectives: Gaining insight into patients' preferences for long-acting injectable (LAI) antipsychotics could aid in mitigating potential barriers to the utilization of LAI in patients with schizophrenia. Methodology: A cross-sectional descriptive study was conducted among schizophrenic patients in Saudi Arabia between June 2023 and October 2023. An analysis was conducted on the responses obtained from the Medication Preference Questionnaire. Results: There was a subtle trend toward favouring oral antipsychotics over LAIs. Patients on oral antipsychotics commonly favoured the following outcomes: "I don't have to worry about taking medicines" (77%), "I can get back to my favourite activity" (71%), and "I feel symptoms will not come back" (65%). Most patients favoured gluteal injections over deltoid injections for the following reasons: easier use (90%), improved symptom relief (73%), lesser side effects (73%), and reduced pain (73%). Overall, 65% of patients favoured the dose once per month as opposed to three times per month (18%) or daily (17%). The common reasons cited by patients who favoured a 1-monthly dose were "less medication-related conflict" (97%) and "dislike to taking too much medication at once (93%)." Conclusion: This study unveiled the presence of a subtle differentiation between LAI antipsychotics and oral antipsychotics in terms of their relative desirability, with a slight inclination toward an increased preference for oral medications. Patients with schizophrenia favoured the gluteal injection over the deltoid injection on account of its greater ease of use, efficacy in symptom relief, absence of adverse effects, and reduced discomfort. Furthermore, patients exhibited a greater inclination towards monthly LAI in comparison to 3-monthly LAI and oral pill antipsychotics.

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Association between culture and the preference for, and perceptions of, 11 routes of medicine administration: A survey in 21 countries and regions

Cited by 2 publications

References 25 publications

Algae-Based Nanoparticles for Oral Drug Delivery Systems

Algae-Based Nanoparticles for Oral Drug Delivery Systems

Schizophrenic patient’s preference for long-acting injectable antipsychotics in Saudi Arabia

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