Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Nathan, Pradeep J.; Lim, Yen Ying; Abbott, Rosemary; Galluzzi, Samantha; Marizzoni, Moira; Babiloni, Claudio; Albani, Diego; Bartrés‐Faz, David; Didic, Mira; Farotti, Lucia; Parnetti, Lucilla; Salvadori, Nicola; Müller, Bernhard; Forloni, Gianluigi; Girtler, Nicola; Hensch, Tilman; Jovicich, Jorge; Leeuwis, Anna E.; Marra, Camillo; Molinuevo, José Luís; Nobili, Flavio; Pariente, Jérémie; Payoux, Pierre; Ranjeva, Jean‐Philippe; Rolandi, E; Rossini, Paolo Maria; Schönknecht, Peter; Soricelli, Andrea; Tsolaki, Magda; Visser, Pieter Jelle; Wiltfang, Jens; Richardson, Jill C.; Bordet, Régis; Blin, Olivier; Frisoni, Giovanni B.

doi:10.1016/j.neurobiolaging.2017.01.013

Cited by 60 publications

(57 citation statements)

References 44 publications

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“…The atrophy of GM volume in the medial temporal lobe is more severe in AD than MCI, which is confirmed by previous MRI findings [33]. The accuracy of hippocampal findings, the key region for information storage and memory in the identification of AD (AUC = 0.839) using the ROC analysis, was relatively higher than in other regions, which confirmed that hippocampal volume is the best-established structural biomarker for AD [21, 34, 35]. …”

Section: Discussionsupporting

confidence: 78%

Combinations of Multiple Neuroimaging Markers using Logistic Regression for Auxiliary Diagnosis of Alzheimer Disease and Mild Cognitive Impairment

et al. 2018

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Background: Multiple neuroimaging modalities have been developed providing various aspects of information on the human brain. Objective: Used together and properly, these complementary multimodal neuroimaging data integrate multisource information which can facilitate a diagnosis and improve the diagnostic accuracy. Methods: In this study, 3 types of brain imaging data (sMRI, FDG-PET, and florbetapir-PET) were fused in the hope to improve diagnostic accuracy, and multivariate methods (logistic regression) were applied to these trimodal neuroimaging indices. Then, the receiver-operating characteristic (ROC) method was used to analyze the outcomes of the logistic classifier, with either each index, multiples from each modality, or all indices from all 3 modalities, to investigate their differential abilities to identify the disease. Results: With increasing numbers of indices within each modality and across modalities, the accuracy of identifying Alzheimer disease (AD) increases to varying degrees. For example, the area under the ROC curve is above 0.98 when all the indices from the 3 imaging data types are combined. Conclusion: Using a combination of different indices, the results confirmed the initial hypothesis that different biomarkers were potentially complementary, and thus the conjoint analysis of multiple information from multiple sources would improve the capability to identify diseases such as AD and mild cognitive impairment.

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Section: Discussionsupporting

confidence: 78%

Combinations of Multiple Neuroimaging Markers using Logistic Regression for Auxiliary Diagnosis of Alzheimer Disease and Mild Cognitive Impairment

et al. 2018

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“…On the other hand, lower 5‐HIAA levels correlated also with a large cluster of atrophy in the precuneus, which is a multimodal cortical hub integrating information from temporal, occipital, and parietal lobes . The precuneus is a very vulnerable region of the aging brain, as its atrophy and dysfunction has been associated with early phases of Alzheimer's disease . Thus, the association between GM atrophy of this specific area with lower 5‐HIAA/5‐HTP CSF levels might reflect the interaction of chronic serotonin depletion specifically present in PKU patients and the time‐dependent changes in the human brain.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria

Padovani

Blau

Leks

et al. 2019

J of Inher Metab Disea

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Biogenic amines synthesis in phenylketonuria (PKU) patients with high phenylalanine (Phe) concentration is thought to be impaired due to inhibition of tyrosine and tryptophan hydroxylases and competition with amino acids at the blood-brain barrier. Dopamine and serotonin deficits might explain brain damage and progressive neuropsychiatric impairment in adult PKU patients. Ten early treated adult PKU patients (mean age 38.2 years) and 15 age-matched controls entered the study.

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“…Moreover, PAL has been successfully used in identification of AD, at various stages of the disease, including very early stages (e.g., Sahakian et al., 1988, Swainson et al., 2001; see also (Barnett, Blackwell, Sahakian, & Robbins, 2016) for a complete review about PAL findings). Finally, the number of errors across all attempts during PAL has recently been shown to correlate with the available biomarkers of AD in a sample of patients with MCI, i.e., CSF levels of tau, P-tau, Ab42, and hippocampal volumes (Nathan, Lim, Abbott, Galuzzi, Marizzoni, Babiloni et al., 2017), strongly arguing for the use of that task to identify hippocampal abnormalities in the context of early AD.…”

Section: Methodsmentioning

confidence: 99%

Refining understanding of working memory buffers through the construct of binding: Evidence from a single case informs theory and clinical practise

Jonin

Calia

Muratot

et al. 2019

Cortex

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Binding operations carried out in working memory enable the integration of information from different sources during online performance. While available evidence suggests that working memory may involve distinct binding functions, whether or not they all involve the episodic buffer as a cognitive substrate remains unclear. Similarly, knowledge about the neural underpinnings of working memory buffers is limited, more specifically regarding the involvement of medial temporal lobe structures. In the present study, we report on the case of patient KA, with developmental amnesia and selective damage to the whole hippocampal system. We found that KA was unable to hold shape-colours associations (relational binding) in working memory. In contrast, he could hold integrated coloured shapes (conjunctive binding) in two different tasks. Otherwise, and as expected, KA was impaired on three relational memory tasks thought to depend on the hippocampus that are widely used in the early detection of Alzheimer's disease. Our results emphasize a dissociation between two binding processes within working memory, suggesting that the visuo-spatial sketchpad could support conjunctive binding, and may rely upon a large cortical network including sub-hippocampal structures. By contrast, we found evidence for a selective impairment of relational binding in working memory when the hippocampal system is compromised, suggesting that the long-term memory deficit observed in amnesic patients may be related to impaired short-term relational binding at encoding. Finally, these findings may inform research on the early detection of Alzheimer's disease as the preservation of conjunctive binding in KA is in sharp contrast with the impaired performance demonstrated very early in this disease.

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Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Cited by 60 publications

References 44 publications

Combinations of Multiple Neuroimaging Markers using Logistic Regression for Auxiliary Diagnosis of Alzheimer Disease and Mild Cognitive Impairment

Combinations of Multiple Neuroimaging Markers using Logistic Regression for Auxiliary Diagnosis of Alzheimer Disease and Mild Cognitive Impairment

Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria

Refining understanding of working memory buffers through the construct of binding: Evidence from a single case informs theory and clinical practise

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