Association between common risk factors and molecular subtypes in breast cancer patients

Türköz, Fatma Paksoy; Solak, Mustafa; Petekkaya, İbrahim; Keskin, Özge; Kertmen, Neyran; Sarici, Furkan; Arık, Zafer; Babacan, Taner; Özışık, Yavuz; Altundağ, Kadri̇

doi:10.1016/j.breast.2012.08.005

Cited by 140 publications

(108 citation statements)

References 33 publications

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“…Several studies conducted to evaluate the effect of BMI at time of diagnostic on histopathological features concluded that obese postmenopausal women develop more frequently ER/PR positive tumors (Biglia et al, 2013). However, others studies showed that obesity and overweight increases the risk of developing triple negative BC subtype, particularly for premenopausal women (Turkoz et al, 2013). Our results revealed that there is an association between BMI and ER-PR-Her2+ tumor subtype.…”

Section: Discussionsupporting

confidence: 43%

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Bouguerra

Guissouma²,

Labidi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have suggested a link between obesity and breast cancer (BC). However, there is no universal consensus, especially in population based studies. Because only few studies have been conducted on African women, we aimed here to assess the relationship between BMI at time of diagnosis and the BC histopathological features among Tunisian patients according to menopausal status using a hospital-based prospective cohort study. Materials and Methods: Clinical and pathological data were collected from 262 patients stratified on four groups according to their BMI. The relationship between BMI and histopathological features at diagnosis was analysed using univariate and multivariate analysis. Receiver-operating characteristic (ROC) curves were used to evaluate the performance of BMI in predicting of high tumor grade, in comparison to ki-67 index of proliferation. Results: Obesity was correlated with larger tumors, advanced grade and with ER-PRHer2+ BC subtype. An association of BMI with tumor size and tumor grade was observed in both premenopausal and postmenopausal women. Additionally, a significant association between BMI and ER+, ER+PR+Her2+ and ER-PR-Her2+ status was revealed for premenopausal patients, while only ER+PR+Her2+ was associated with BMI for postmenopausal women. Finally, our results showed that compared to Ki67 proliferation index, BMI is a useful prognostic marker of high grade BC tumors. Conclusions: These data are the first to show that in Tunisia obese women suffering from BC have significantly larger tumors and advanced tumor grade and that higher BMI might influence tumor characteristics and behavior.

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Section: Discussionsupporting

confidence: 43%

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Bouguerra

Guissouma²,

Labidi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…14,26 Though there is no significant correlation between family history and different breast cancer subtypes but a study reported approximately 28% TNBC patients with family history being highest among all subtypes. 27 TNBC is repeatedly found to occur in premenopausal women. Early menarche, young age at first childbirth, increased parity, oral contraceptives, obesity these are some common risk factors for TNBC in general.…”

Section: Tnbc Risk Factors For Bangladeshi Womenmentioning

confidence: 99%

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

Zohora

Rabbi

2018

Int J Res Med Sci

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Breast cancer is the second most common type of cancer in Bangladesh. Although significant improvement has been made in breast cancer treatment and management, Triple Negative Breast Cancer (TNBC) is still the least known breast cancer subtype in this country. TNBC is well known for its aggressive nature and limited therapeutic options when compared to other breast cancer subtypes. Several population-based studies indicated high prevalence of TNBC in African women in addition to few recent studies indicating a growing number of TNBC patients among Asian population. However, there is a lack of evidence on TNBC patients in Bangladesh due to limited knowledge and awareness. In this paper we review the epidemiology, general risk factors and clinical characteristics of TNBC to find out the correlation between TNBC and other conventional breast cancer subtypes in Bangladesh. Some diagnostic and therapeutic approaches as well as future novel solutions for TNBC are also discussed to understand the pathologic process and treatment strategies of TNBC. Literature review reveals that, there is a lack of TNBC studies in Bangladesh. Therefore, more investigations should be carried out to address the degree of vulnerability of TNBC in breast cancer patients of Bangladesh.

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“…Although the molecular differences between these subtypes have been described in the literature, there is extensive heterogeneity in the distribution of molecular subtypes 44,60,61 and their causes around the world 62 . Further research is necessary to determine if these differences are due to tumor biology or rather to poor pre-analytic management of the samples, including differences in fixation times and improper interpretation 63,64 .…”

Section: Tumor Biology Heterogeneity Concernsmentioning

confidence: 99%

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

Torres-Mejı́a

Navarro

Tuesca-Molina

et al. 2017

RIC

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Breast cancer is the most common malignant tumor among women of reproductive age and is also the most costly according to European reports. In this context, the aim of the present review is to identify factors that make breast cancer in premenopausal women an epidemiological challenge in developing countries. Epidemiological aspects of breast cancer, including risk factors, early detection methods, and treatment, are addressed. Breast cancer in premenopausal women should be included in the political and strategic agendas in developing countries to direct the necessary resources for prevention, detection, and control. (REV INVES CLIN. 2017;69:59-65)

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Association between common risk factors and molecular subtypes in breast cancer patients

Cited by 140 publications

References 33 publications

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Study on epidemiology, risk factors and clinical characteristics of triple negative breast cancer in Bangladesh

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

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