Association between common polymorphisms in ERCC gene and glioma risk

Abstract

Background:A number of studies have investigated the roles of excision repair cross complementation group 1 (ERCC1), ERCC2, and ERCC5 genes polymorphisms in the development of glioma; however, the results were inconsistent. Here, we performed a meta-analysis to investigate the association between 6 polymorphisms in the ERCC genes (rs3212986, rs11615, rs13181, rs1799793, rs238406, rs17655) and glioma risk.Methods:The PubMed, Embase, and Web of science were searched up to September 6, 2016, for studies on the association between ERCC polymorphisms and glioma risk. A fixed-effects or random-effects model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. Sensitivity and cumulative meta-analyses were also performed.Results:A total of 15 studies were eligible for the pooled analysis, conducted in 2 populations of ethnic descent: 8 Europeans and 7 Asians. The results showed that ERCC1 rs3212986 polymorphism was positively associated with glioma [AA vs CC: odds ratio (OR) = 1.298, 95% confidence interval (95% CI) = 1.043–1.230, P = .025]. Association of the ERCC2 rs13181 and rs1799793 polymorphisms was only observed in Asians (CC vs AA for rs13181: OR = 1.539, 95% CI = 1.122–2.109, P = .007; AA vs GG for rs1799793: OR = 1.474, 95% CI = 1.090–1.994, P = .012). However, no association was observed between glioma risk and ERCC1 rs11615, ERCC2 rs238406, and ERCC5 rs17655 polymorphisms. Moreover, sensitivity and cumulative meta-analyses confirmed the stability of the results.Conclusions:Our meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.

Association of XRCC1 rs1799782 and ERCC2 rs13181 Polymorphisms with Glioma Risk: A Systematic Review and Meta-Analysis

“…Based on meta-analysis, the AC genotypes of ERCC2 rs13181 in Asians and Caucasians and the CC genotypes in Caucasians were associated to an increased risk of gliomas. This result corroborates the ndings reported by Qian et al [6], who reviewed fteen studies and conducted a meta-analysis [38]. These investigators reported increased risks for the development of glial cell tumors only in Asians with the CC and AC genotypes (Figs.…”

“…There are published reports on the relationship between some ERCC2 SNPs and the risk of systemic tumors with the most studied being ERCC2 Lys751Gln (rs13181). This polymorphism is characterized by the replacement of thymine (T) by guanine (G) at the locus 751, which changes the enzymatic activity of some encoded proteins, such as helicase, and can be associated with several types of cancers, including gastric, esophageal, hepatocellular carcinoma, non-small cell lung, prostate, skin, and bladder cancers, as well as gliomas [6]. Our current study reviewed and analyzed ten published reports that included ve based on Asian populations, four based on Caucasian populations, and one that included both populations and the genotypes studied in these reports were AC, CC, GG, and TG.…”

“…Many environmental and lifestyle factors are considered to be associated with increased risk for the development of gliomas, including some occupations, exposure to ionizing radiation, and smoking, among others. Hereditary factors may also play an important role in the development of gliomas as genetic studies have identi ed several genes that may be associated with the onset and/or growth of these tumors [5][6][7].…”

Association between nucleotide excision repair gene polymorphism and colorectal cancer risk

“…polymorphism was significantly associated with glioma risk under the following genetic models, and no association was observed between glioma risk and ERCC5 rs17655. 23 However, Hou et al found that rs6498486 polymorphism not associated with risk of colorectal cancer and rs3212986 may be associated with colorectal cancer risk in a Chinese population. 20 In addition, in recently published metaanalyses, Zeng et al 24 suggests that the ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.…”

Effects of EZH2 Polymorphisms on Susceptibility to Various Carcinomas: Evidence from 6 Publications

“…The quality of the studies was modified from previous meta-analysis and independently assessed by 2 authors (Tables 1 and 2) [17,18]. Quality scores ranged from 0 points to 13 points and 0 points means the while 13 points means the best.…”