Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population

Abstract

Background Exposure to heavy metals in the environment is widespread, while the relationship between combined exposure to heavy metals and dyslipidemia is unclear. Methods A cross-sectional study was performed, and 3544 participants aged 30 years or older were included in the analyses. Heavy metal concentrations in plasma were based on inductively coupled plasma‒mass spectrometry. The relationship between heavy metals and dyslipidemia was estimated by logistic regression. BKMR was used to evaluate metal mixtures and their potential interactions. Results In logistic regression analysis, participants in the fourth quartile of Fe and Zn (Fe > 1352.38 µg/L; Zn > 4401.42 µg/L) had a relatively higher risk of dyslipidemia (Fe, OR = 1.13, 95% CI: 0.92,1.38; Zn, OR = 1.30, 95% CI: 1.03,1.64). After sex stratification, females in the third quartile of plasma Zn (1062.05-4401.42 µg/L) had a higher relative risk of dyslipidemia (OR = 1.75, 95% CI: 1.28, 2.38). In BKMR analysis, metal mixtures were negatively associated with dyslipidemia in females when all metal concentrations were above the 50th percentile. In the total population (estimated from 0.030 to 0.031), As was positively associated with dyslipidemia when other metals were controlled at the 25th, 50th, or 75th percentile, respectively, and As was below the 75th percentile. In females (estimated from − 0.037 to -0.031), Zn was negatively associated with dyslipidemia when it was above the 50th percentile. Conclusion This study indicated that As was positively associated with dyslipidemia and that Zn may be negatively associated with dyslipidemia in females. Combined metal exposure was negatively associated with dyslipidemia in females. Females with low plasma Zn levels are more likely to develop dyslipidemia and should receive more clinical attention in this population.

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population

“…In addition, different types of blood cells play different roles in the systemic inflammatory response. Moreover, based on the results of previous studies conducted by the group, a correlation between the presence of heavy metals and a variety of diseases was found in our study participants [ 20 – 22 ], which are closely related to inflammation [ 31 , 32 ]. Meanwhile, metal exposure induces an inflammatory response in the organism, which is manifested by different degrees of changes in blood cell levels [ 33 , 34 ].…”

“…Hypertension was defined as one or more of the following conditions or currently taking antihypertensive medication: systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg [ 28 ]. Dyslipidemia was defined as one or more of the following conditions and/or taking lipid-lowering medications: total cholesterol ≥ 6.22 mmol/L, triglycerides ≥ 2.26 mmol/L, low-density lipoprotein cholesterol ≥ 4.14 mmol/L, and high-density lipoprotein cholesterol < 1.04 mmol/L [ 20 ].…”

“…Thus, the level of metal exposure for residents in the area is potentially different from that of other places. The group's previous investigations found that plasma heavy metal levels of most of the residents in the area were associated with a variety of diseases [20][21][22], but the association with systemic immune inflammation remains unknown. Therefore, the present study was conducted to comprehensively evaluate the potential effects of heavy metal exposure on the body's immune-inflammatory function by detecting the plasma concentrations of heavy metals (including As, Cd, Cu, Fe, Mn, Ni, Pb, and Zn) in the population and by measuring and calculating the levels of serum immune-inflammatory markers in the study population to standardize the use of these immuneinflammatory indicators in the population.…”

Effects of Polycyclic Aromatic Hydrocarbon Exposure and Telomere Length and their Interaction on Blood Lipids in Coal Miners

“…However, there are still deficiencies. First, as a cross-sectional study, we could not elucidate the causal relationship between PAH exposure, telomere length, and dyslipidemia; second, dyslipidemia may also be influenced by other factors such as heavy metals, 40 high temperature, 41 and noise 42 due to the specificity of the working environment of coal miners. However, our study did not consider these occupational factors that may have an impact on the outcome; finally, the subjects were selected from a single coal mine in Shanxi Province, so the findings may not be generalizable; therefore, further exploration and validation through a large sample cohort study are needed.…”

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

“…Additional epidemiological studies have found an association between body As burden and the risk of dyslipidemia and atherosclerosis [ 166 , 167 ]. In agreement with these epidemiological data, laboratory findings demonstrated an adverse effect of As exposure on serum lipid profile, characterized by reduced HDL-C and increased circulating TC, TG, and LDL-C concentrations [ 168 ].…”