Association between collagen production and mechanical stretching in dermal extracellular matrix: In vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study

Turlier, Virginie; Delalleau, Alexandre; Casas, Christiane; Rouquier, Amandine; Bianchi, P; Alvarez, Sandrine; Josse, Gwendal; Briant, Alain; Dahan, Serge; Saint-Martory, C.; Theunis, Jennifer; Bensafi-Benaouda, Amel; Degouy, Arnaud; Schmitt, Anne-Marie; Redoulès, Daniel

doi:10.1016/j.jdermsci.2012.12.006

Cited by 75 publications

(62 citation statements)

References 19 publications

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“…Therefore, the areas of high signal identified on fat-saturated T2 correspond to both HA and bound water. Although certain authors suggested that cross-linked HA fillers may lead to increased procollagen expression due to mechanical stretching in the dermal extracellular matrix [13,22], these observations were not confirmed by other studies [21]. Therefore, theoretically the areas we identified on MRI could also correspond to a mixture of injected HA, bound water and newly formed procollagen.…”

Section: Discussioncontrasting

confidence: 63%

“…Histologic analyses of the forearm, buttock and iliac crest skin injected with different types of cross-linked HA have shown that HA implants have the ability to bind water and thereby provide volume and support to the injected tissue for up to 12 months without causing fibrosis or foreign body reactions [18,19,20,21]. Recent studies suggest that these fillers may stimulate dermal collagen anabolism by inducing increased procollagen and tissue inhibitor of matrix-degrading metalloproteinases (TIMP-1) levels [13,22]. …”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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Objective: This prospective observational study evaluated magnetic resonance imaging (MRI) findings of hyaluronic acid (HA) injections used for the correction of HIV-associated facial lipoatrophy. Methods: Ten consecutive males underwent subdermal HA injection (mean 1.3 ± 0.6 ml per side) and MRI examinations prior to and then 1, 6 and 12 months after injection. Two radiologists blinded to the clinical data assessed morphologic and quantitative changes. Results: MRI revealed HA deposition in the subdermal and deep fat compartments. A significant HA volume increase was observed 1 month after injection (mean increase 331%, p < 0.0001) as compared to the injected amount. No volume reduction occurred at 12 months (p = 0.9961). The measured bound water content did not change (p > 0.9991), whereas skin thickness and tissue vascularization increased during the first 6 months (p = 0.01). Conclusion: Our data show that the cosmetic results of HA injections are caused by water binding in the deep facial fat and by a transient increase in vascularization and skin thickness.

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Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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“…These cellular alterations were accompanied by restoration of TGF-b signaling and type I collagen production in fibroblasts Quan et al 2013). These results provide proof of principle that enhancing mechanical tension within the dermis of chronologically aged or photoaged skin effectively activates fibroblasts to achieve a more youthful state, which is clinically readily observable (Turlier et al 2013). These results also provide further support for the concept that decline of fibroblast function, in chronologically aged and photoaging human skin, reflects the degraded properties of the dermal extracellular matrix microenvironment and is reversible.…”

Section: Restoration Of Mechanical Tension Restores Extracellular Matmentioning

confidence: 59%

Natural and Sun-Induced Aging of Human Skin

Rittié

Fisher

2015

Cold Spring Harbor Perspectives in Medicine

394

386

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With worldwide expansion of the aging population, research on age-related pathologies is receiving growing interest. In this review, we discuss current knowledge regarding the decline of skin structure and function induced by the passage of time (chronological aging) and chronic exposure to solar UV irradiation ( photoaging). Nearly every aspect of skin biology is affected by aging. The self-renewing capability of the epidermis, which provides vital barrier function, is diminished with age. Vital thermoregulation function of eccrine sweat glands is also altered with age. The dermal collagenous extracellular matrix, which comprises the bulk of skin and confers strength and resiliency, undergoes gradual fragmentation, which deleteriously impacts skin mechanical properties and dermal cell functions. Aging also affects wound repair, pigmentation, innervation, immunity, vasculature, and subcutaneous fat homeostasis. Altogether, age-related alterations of skin lead to age-related skin fragility and diseases. S kin, like many other organs, undergoes deleterious changes with the passage of time and associated hormonal and dietary variations. Unlike most other organs, however, skin is also directly affected by exposure to the environment, especially UV irradiation from the sun. Chronic exposure to UV irradiation causes an aged phenotype ( photoaging) that is superimposed with aging caused by the passage of time (chronological aging). As a result, areas of the body that are frequently exposed to the sun such as the face, neck, forearms, or back of the hands acquire visible signs of aging more rapidly than other areas of the body.Skin serves two vital functions. First, skin serves as a barrier; it protects physical, chemical, and bacteriological intrusion in the body, and prevents dehydration by evaporative water loss. Second, skin allows thermoregulation through regulation of skin-hosted vasculature and eccrine sweat glands. In addition to these vital functions, skin mediates the sense of touch and plays a role in immune surveillance, hormone production, and social communication. Each of these functions is affected with aging. In general, alterations of skin structure and function appear earlier and are more pronounced in photoaged than in chronologically aged skin. Evidently, photoaging is a cumulative process and, as such, is more severe in older individuals.Passage of time and repeated exposure to harmful aspects of the environment alter both the epidermal and dermal compartments of the skin. Clinically, chronologically aged skin ap-

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“…8 Subsequent fibroblast activation and neocollagenesis only result in partial HA filler engraftment into the surrounding tissue. [9][10][11] Due to filler migration, degradation, and lack of filler engraftment into the surrounding tissue, reinjection of the fillers is often required. Thus, there is a need for a more durable, shaped-defined HA filler with improved tissue engraftment properties.…”

mentioning

confidence: 99%

Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

Cheng

Shih

et al. 2017

Tissue Engineering Part A

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Introduction: Hyaluronic acid (HA)-based fillers are used for various cosmetic procedures. However, due to filler migration and degradation, reinjections of the fillers are often required. Methacrylated HA (MA-HA) can be made into injectable shape-memorizing fillers (three-dimensional [3D] MA-HA) aimed to address these issues. In this study, shape retention, firmness, and biocompatibility of 3D MA-HA injected subcutaneously in mice were evaluated. Materials and Methods: Fifteen mice, each receiving two subcutaneous injections in their back, were divided into four groups receiving HA, MA-HA, 3D MA-HA, or saline, respectively. Digital imaging, scanning electron microscope (SEM) and in vivo imaging system (IVIS), durometry, and histology were utilized to evaluate in vitro/ vivo degradation and migration, material firmness, and the angiogenic (CD31) and immunogenic (CD45) response of the host tissue toward the injected materials. Results: Digital imaging, SEM, and IVIS revealed that 3D MA-HA fillers maintained their predetermined shape for at least 30 days in vitro and in vivo. Little volume effects were noted in the saline and other control groups. There were no differences in skin firmness between the groups or over time. Histology showed intact skin architecture in all groups. Three-dimensional MA-HA maintained its macroporous structure with significant angiogenesis at the 3D MA-HA/skin interfaces and throughout the 3D MA-HA. There was no significant inflammatory response to any of the injected materials. Conclusion: 3D MA-HA showed remarkable tissue compatibility, compliance, and shape predictability, as well as retention, and thus might be suitable for various skin sculpting and soft tissue reconstruction purposes.

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Association between collagen production and mechanical stretching in dermal extracellular matrix: In vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study

Cited by 75 publications

References 19 publications

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Natural and Sun-Induced Aging of Human Skin

Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

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