Association between cognition and suicidal ideation in patients with major depressive disorder: A longitudinal study

Lan, Xiaofeng; Zhou, Yanling; Zheng, Wei; Zhan, Yongle; Liu, Weijian; Wang, Chengyu; Jiang, Miaoling; Yu, Min; Zhang, Bin; Ning, Yuping

doi:10.1016/j.jad.2020.03.141

Cited by 19 publications

(7 citation statements)

References 47 publications

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“…This finding indicates a possible relationship between poorer visual learning performance and severity of suicidal ideation in young adults. Although the lack of significance for the other aspects of cognitive functioning (i.e., verbal learning, visual memory and verbal memory) conflicts with some of the existing findings (Barzilay et al, 2019;Lan et al, 2020;McHugh et al, 2021;Richard-Devantoy et al, 2015), this disparity may due to the relatively small sample size in the current study. A larger-scale study involving young adults with a broader range in the severity of suicidality is recommended to further validate the gamified cognitive assessment and to understand its efficiency in predicting suicidal behaviour.…”

Section: Discussioncontrasting

confidence: 93%

CogGame: Gamified Cognitive Assessments in Young Adults with Suicidal Thoughts

Shin

LaMonica

Mowszowski

et al. 2022

Preprint

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Introduction The susceptibility to suicidal behaviour has been linked to cognitive functioning deficits. Gamified assessments have emerged as a practical and engaging approach to assess these deficits, though their acceptability amongst young adults with suicidal thoughts is currently understudied. Methods Thirteen young Australian adults aged 18 to 25 years who experienced suicidal thoughts in the past year were recruited to evaluate the smartphone based CogGame app. Inductive thematic analysis was utilised to identify the themes obtained from the interviews. The relationships between cognitive functioning deficits and the severity of suicidal thoughts were explored by correlational analyses. Results All participants found the GogGame app easy to learn to use and navigate. Positive experiences and high user satisfaction were reported with the use of CogGame app. Major areas for improvement include having clearer instructions and app information, adjusting the difficulty of the exercises, and addressing a few technical issues such as decreasing loading time. Higher levels of suicidal thoughts were found to be significantly associated with poorer visual learning performance on the CogGame app (p = .01). Conclusion Positive participant experiences with CogGame revealed the promising potential of gamified assessments to measure cognitive functioning in young adults with suicidal thoughts.

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Section: Discussioncontrasting

confidence: 93%

CogGame: Gamified Cognitive Assessments in Young Adults with Suicidal Thoughts

Shin

LaMonica

Mowszowski

et al. 2022

Preprint

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“…The MCCB is a comprehensive measurement including seven cognitive domains covering a wide range of neurocognitive functions, and it has high reliability and validity in schizophrenia (16). Several studies have used the MCCB to evaluate the level of cognition in MDD patients, and it has achieved great success (17)(18)(19). Our previous research also found good psychometric properties and revealed four cognitive factors when applying the MCCB to Chinese adult MDD patients (13).…”

Section: Introductionmentioning

confidence: 80%

The MATRICS Consensus Cognitive Battery: Psychometric Properties of the Chinese Version in Young Patients With Major Depression Disorder

et al. 2021

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Background: Young patients with major depressive disorder are also associated with cognitive deficits. The development of an accurate and effective battery to measure cognitive impairment in young patients with major depressive disorder (Y-MDD) is necessary for both research and clinical practice. This study was designed to test the psychometric properties of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) in Y-MDD.Method: Fifty Y-MDD patients, 38 euthymic young patients with bipolar disorder (Y-BD), and 51 healthy teenagers were recruited. The MCCB and the Montreal Cognitive Assessment (MoCA) were administered to assess cognitive impairment at baseline. The MCCB was also assessed 2 weeks later in Y-MDD patients. All subjects were between the ages of 13 and 24 years.Result: In the current study, cognitive impairment was greater in Y-BD patients than in Y-MDD patients in some domains. The MCCB has good internal consistency and reliability in Y-MDD patients. The Pearson correlation coefficients for retest reliability were good. Our findings also revealed an acceptable correlation between the MCCB and the MoCA, indicating good concurrent validity of the MCCB. Furthermore, exploratory factor analysis of the MCCB in Y-MDD patients revealed five domains with acceptable internal structures.Conclusion: The MCCB has acceptable psychometric properties and is a sensitive battery of cognitive impairment in Y-MDD patients. In the future, additional studies need to be carried out with larger samples while controlling for the use of psychotropic medications and antidepressants to validate the findings of the present study.

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“…The HAMD-17 has displayed good psychometric properties with an acceptable validity, reliability and sensitivity to symptom change in patients with major depressive disorder, such as intraclass correlation coefficients of approximately 0.95 27. The Chinese version of HAMD-17 has been validated in the Chinese population and has good psychometric properties 28 29. There have been a number of studies using it as an indicator of assessing depression interventions or newly developed depression scales for Chinese people 30–33…”

Section: Methods and Analysismentioning

confidence: 99%

Using functional near-infrared spectroscopy to study effects of virtual reality intervention for adolescents with depression in a clinical setting in China: study protocol for a prospective, randomised, controlled trial

Yu,

Wang,

et al. 2023

BMJ Open

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IntroductionAdolescent depression has been shown to be associated with many devastating psychosocial outcomes. However, there are many barriers that may prevent depressed individuals from receiving specialised treatment. Virtual reality (VR) technology has shown promise as one avenue for overcoming these challenges. This study first aims to evaluate the effectiveness of VR intervention on adolescent depression symptoms, and second, to determine the intervention’s underlying mechanism of effect using functional near-infrared spectroscopy (fNIRS).Methods and analysisThis is a single-centre, prospective, randomised controlled clinical trial. Sixty-six eligible adolescents aged 12–18 years with a diagnosis of depression will be randomised in a 1:1 ratio to either the VR treatment group or the conventional treatment group. All patients for both groups will receive usual treatment during a 4-week intervention period. In addition, patients randomised to VR treatment group (n=33) will complete three 20 min VR sessions including attention, executive function and relaxation training per week. Moreover, 33 healthy adolescents will be recruited as the general population. Primary outcome (ie, depressive symptoms) and secondary outcomes (ie, anxiety symptoms, executive function, treatment emergent symptoms, haemoglobin changes measured by fNIRS) will be collected at preintervention, immediately postintervention and at 4 weeks follow-up. The data assessor and analyst will be blinded to group membership.Ethics and disseminationEthical approval has been obtained from the Ethics Committee of Lishui Second People’s Hospital. Written informed consent will be obtained for all participants. Results will be disseminated through peer-reviewed journals, national or international conference presentations, media outlets, the internet and various community activities.Trial registration numberChiCTR2300067747.

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Association between cognition and suicidal ideation in patients with major depressive disorder: A longitudinal study

Cited by 19 publications

References 47 publications

CogGame: Gamified Cognitive Assessments in Young Adults with Suicidal Thoughts

CogGame: Gamified Cognitive Assessments in Young Adults with Suicidal Thoughts

The MATRICS Consensus Cognitive Battery: Psychometric Properties of the Chinese Version in Young Patients With Major Depression Disorder

Using functional near-infrared spectroscopy to study effects of virtual reality intervention for adolescents with depression in a clinical setting in China: study protocol for a prospective, randomised, controlled trial

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