Association between cognition and gene polymorphisms involved in thrombosis and haemostasis

Quinn, Terence J.; Alghamdi, Jahad; Padmanabhan, Sandosh; Porteous, David J.; Smith, Blair H.; Hocking, Lynne J.; Deary, Ian J.; Gallacher, John; Messow, Claudia-Martina; Stott, David J.

doi:10.1007/s11357-015-9820-y

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Two studies [ 8, 9 ] examined fibrinogen in relationship to global cognition with neither study finding genetic evidence for a causal relationship. In addition to fibrinogen, Quinn and colleagues [ 9 ] also investigated D-dimer, plasminogen activator inhibitor and von Willebrand factor but found no evidence for an association between any of the IVs for these measures and global cognition ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies

Kuźma

Hannon

Zhou

et al. 2018

JAD

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Background:Numerous risk factors for dementia are well established, though the causal nature of these associations remains unclear.Objective:To systematically review Mendelian randomization (MR) studies investigating causal relationships between risk factors and global cognitive function or dementia.Methods:We searched five databases from inception to February 2017 and conducted citation searches including MR studies investigating the association between any risk factor and global cognitive function, all-cause dementia or dementia subtypes. Two reviewers independently assessed titles and abstracts, full-texts, and study quality.Results:We included 18 MR studies investigating education, lifestyle factors, cardiovascular factors and related biomarkers, diabetes related and other endocrine factors, and telomere length. Studies were of predominantly good quality, however eight received low ratings for sample size and statistical power. The most convincing causal evidence was found for an association of shorter telomeres with increased risk of Alzheimer’s disease (AD). Causal evidence was weaker for smoking quantity, vitamin D, homocysteine, systolic blood pressure, fasting glucose, insulin sensitivity, and high-density lipoprotein cholesterol. Well-replicated associations were not present for most exposures and we cannot fully discount survival and diagnostic bias, or the potential for pleiotropic effects.Conclusions:Genetic evidence supported a causal association between telomere length and AD, whereas limited evidence for other risk factors was largely inconclusive with tentative evidence for smoking quantity, vitamin D, homocysteine, and selected metabolic markers. The lack of stronger evidence for other risk factors may reflect insufficient statistical power. Larger well-designed MR studies would therefore help establish the causal status of these dementia risk factors.

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Section: Resultsmentioning

confidence: 99%

“…If results from multiple cohorts were combined, we extracted only pooled findings. We also tried to contact corresponding authors of studies where relevant data was not fully reported [ 7–9 ] and received additional data for one study [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies

Kuźma

Hannon

Zhou

et al. 2018

JAD

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“…[28][29][30]. Эти изменения системы гемостаза увеличивают не только риск сердечно-сосудистых событий, но и приводят к когнитивным расстройствам [31]. Также сообщалось, что у пожилых людей отмечается повышение уровня различных маркеров воспаления, таких как С-реактивный белок и интерлейкин-6 [32].…”

Section: ишемический и геморрагический риск у пациентов пожилого и ст...unclassified

Features of the management of elderly patients with non ST segment elevation myocardial infarction: analysis of risk factors, diagnosis and treatment strategy

Zajnobidinov

Khelimskii

Baranov

et al. 2023

SJCEM

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Despite the technological developments in the healthcare industry, cardiovascular disease mortality occupies a leading place among the structure of general mortality of the population. The use of modern treatment methods, especially, percutaneous coronary intervention, provides timely assistance to patients with acute coronary syndrome and helps to reduce mortality frequency. Currently, clear algorithms for the management of patients with ST-segment elevation myocardial infarction have been developed. However, despite it, there are paradigms in the management of patients with non-ST-segment elevation myocardial infarction (NSTEMI). This is primarily due to the fact that the vast majority of patients with NSTEMI are elderly and senile persons. This review article presented the main factors that adversely affect short- and long-term prognosis and results of clinical studies dedicated to the study of this problem.

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Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial

Baker

Wolfson

Peterson

et al. 2020

Open Forum Infectious Diseases

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Background Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods Treatment effects of edoxaban (30 mg), a direct factor Xa inhibitor, vs placebo were investigated in a randomized, double-blind crossover trial among participants with HIV and viral suppression and D-dimer levels ≥100 ng/mL. During each 4-month crossover period, blood measures of coagulation, inflammation, and immune activation were assessed. Analyses of change on edoxaban vs change on placebo used linear mixed models. Results Forty-four participants were randomized, and 40 completed at least 1 visit during each study period. The mean age was 49 years, and the CD4+ count was 739 cells/mm3. Edoxaban treatment led to declines in D-dimer (44%) and thrombin-antithrombin complex (26%) but did not lower inflammatory or immune activation measures. More bruising or bleeding events occurred during edoxaban (n = 28) than during placebo or no drug periods (n = 15). Conclusions The direct factor Xa inhibitor edoxaban led to a substantial reduction in coagulation but no effect on inflammation or immune activation. These results do not support that hypercoagulation contributes to ongoing inflammation during chronic antiretroviral therapy–treated HIV disease.

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Association between cognition and gene polymorphisms involved in thrombosis and haemostasis

Cited by 3 publications

References 21 publications

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies

Features of the management of elderly patients with non ST segment elevation myocardial infarction: analysis of risk factors, diagnosis and treatment strategy

Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial

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