Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder

Lee, Kyu Young; Song, Joo Yun; Kim, Se Hyun; Kim, Seong Chan; Joo, Eun Jeong; Ahn, Yong Min; Kim, Yong Sik

doi:10.1016/j.pnpbp.2010.06.010

Cited by 70 publications

(52 citation statements)

References 56 publications

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“…Those results have been replicated in other populations, such as Caucasian 38 and Japanese 39 both healthy subjects and in a population of Korean bipolar patients. 40 Likewise, in a study conducted by Bandin et al, it was found that obese women with C genetic variants in CLOCK 3111T/C displayed a delayed phase in peripheral temperature which characterizes evening-type subjects. 14 Likewise, associations between CLOCK SNPs and obesity have been demonstrated.…”

Section: Discussionmentioning

confidence: 95%

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C

et al. 2016

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Section: Discussionmentioning

confidence: 95%

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C

et al. 2016

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“…Of note, adult ADHD is linked with blunted Per2 expression (Baird et al, 2012). It is also interesting that the other clock genes with altered circadian profiles in ENT1 KO mice, Clock and Dbp, are associated with ADHD (Kissling et al, 2008;Roybal et al, 2007;Xu et al, 2010), bipolar disorder (Le-Niculescu et al, 2008;Lee et al, 2010;Shi et al, 2008;Soria et al, 2010), anxiety (Le-Niculescu et al, 2011a), and AUD (Le-Niculescu et al, 2011b;Le-Niculescu et al, 2008). Interestingly, ENT1 KO mice display mania-like behavior (Ruby et al, 2011) similar to Dbp KO mice (Le-Niculescu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Adenosinergic Regulation of Striatal Clock Gene Expression and Ethanol Intake During Constant Light

Ruby

Vadnie

Hinton

et al. 2014

Neuropsychopharmacol

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Circadian rhythm and sleep disruptions occur frequently in individuals with alcohol use disorders (AUD) and present significant barriers to treatment. Recently, a variant of adenosine transporter, equilibrative nucleoside transporter 1 (ENT1), was associated with the cooccurrence of sleep problems and AUD. We have previously shown that mice lacking ENT1 (ENT1 KO) have reduced adenosine levels in the striatum and drink more alcohol compared with wild types (WT). However, it is unknown whether ENT1 deletion disrupts circadian rhythms, which may contribute to alcohol preference in ENT1 KO mice. Here we used these mice to determine whether endogenous adenosine regulates circadian genetic and behavioral rhythms and influences alcohol intake during chronodisruption. We examined circadian locomotor activity in ENT1 KO vs WT littermates and found that ENT1 KO mice were both active earlier and hyperactive compared with WT mice at night. We used real-time PCR and immunohistochemistry to estimate striatal clock gene levels and found that PER2 expression in the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism. Next, we exposed ENT1 KO and WT mice to constant light (LL) and found further elevation in ethanol intake in ENT1 KO, but not in WT mice, supporting the notion that circadian dysfunction may contribute to increased alcohol intake in ENT1 KO mice. Finally, we showed that A2AR agonist administration normalized PER1 and PER2 expression and circadian locomotor activity in ENT1 KO mice. Together, our results demonstrate that adenosine signaling regulates cellular and behavioral circadian timing and influences alcohol intake during chronodisruption.

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“…Several studies were conducted on a single nucleotide polymorphism (SNP), in which there is a substitution of thymine nucleotide (T) for cytosine (C) at position 3111 of this gene (SNP T3111C). Some of these studies have revealed that patients with BD which have at least one copy of allele 3111C have an evening chronotype (Katzenberg, Young et al 1998, Benedetti, Dallaspezia et al 2007, Lee, Song et al 2010, with a relatively late onset of sleep and an inferior total sleep time (Benedetti, Dallaspezia et al 2007). The homozygous for this allele 3111C present several differences from the 3111T allele homozygous or heterozygous, in particular, show a doubling of the rate of recurrence of bipolar episodes and an increased recurrence of insomnia , Serretti, Cusin et al 2005.…”

Section: Clock Genesmentioning

confidence: 99%

The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles

Abreu

Bragança²

2015

Journal of Affective Disorders

117

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Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder

Cited by 70 publications

References 56 publications

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C

Adenosinergic Regulation of Striatal Clock Gene Expression and Ethanol Intake During Constant Light

The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles

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