Association Between Clinical Severity of Childhood Asthma and Serum Leptin Levels

Tanju, İlhan Asya; Çekmez, Ferhat; Aydınöz, Seçil; Karademır, Ferhan; Süleymanoğlu, Selami; Göçmen, İsmail

doi:10.1007/s12098-010-0281-0

Cited by 14 publications

(15 citation statements)

References 18 publications

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“…Clinic-based studies of prepubertal asthmatic children, mostly boys, showed that greater serum leptin concentrations were associated with greater clinical asthma severity [ 61 ], lower peak expiratory flow rates [ 60 ], greater severity of exercise induced bronchoconstriction [ 56 ], and higher serum total IgE concentrations [ 57 ]. Further, some studies have found these associations to be independent of BMI [ 56 , 61 ]. In another study of peripubertal/postpubertal asthmatic subjects, Kattan et al found a positive correlation between serum leptin and maximum asthma symptom days among girls.…”

Section: Leptinmentioning

confidence: 99%

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies

2013

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Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and resistin) or anti-inflammatory (such as adiponectin). Effects of these adipokines on the lungs have the potential to evoke or exacerbate asthma. This review summarizes basic mechanistic data through population-based and clinical studies addressing the potential role of adipokines in asthma. Augmenting circulating concentrations of adiponectin attenuates allergic airway inflammation and airway hyperresponsiveness in mice. Murine data is supported by human data that suggest that low serum adiponectin is associated with greater risk for asthma among women and peripubertal girls. Further, higher serum total adiponectin may be associated with lower clinical asthma severity among children and women with asthma. In contrast, exogenous administration of leptin results in augmented allergic airway hyperresponsiveness in mice. Alveolar macrophages obtained from obese asthmatics are uniquely sensitive to leptin in terms of their potential to augment inflammation. Consistent with this basic mechanistic data, epidemiologic studies demonstrate that higher serum leptin is associated with greater asthma prevalence and/or severity and that these associations may be stronger among women, postpubertal girls, and prepubertal boys. The role of adipokines in asthma is still evolving, and it is not currently known whether modulation of adipokines may be helpful in asthma prevention or treatment.

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Section: Leptinmentioning

confidence: 99%

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies

2013

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“…Serum leptin concentrations were positively associated with NHLBI category of asthma severity in a study of both sexes, regardless of BMI [31]. In a separate unadjusted analysis of prepubertal asthmatic children, mostly boys, serum leptin was associated with lower peak expiratory flow rates [29] and higher serum total IgE levels [28].…”

Section: Leptin and Pulmonary Diseasesmentioning

confidence: 99%

“…Although these findings were not entirely reproduced in a human interventional study of mild atopic asthma [37], epidemiologic evidence suggests that greater serum leptin concentrations are associated with more severe asthma, particularly among prepubertal boys and peripubertal/postpubertal girls [31, 32]. …”

Section: Figurementioning

confidence: 99%

Leptin, adiponectin and pulmonary diseases

2012

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“…The serum OX40L levels were significantly increased in asthmatic children during exacerbations and correlated with total eosinophil count . Serum leptin levels and body mass index have also related to the severity of inflammation in childhood asthma . However, further investigations are needed to clarify the role of these systemic biomarkers in various aspects of asthma.…”

Section: Biomarkers In Asthmamentioning

confidence: 99%

Biomolecular markers in assessment and treatment of asthma

et al. 2014

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Asthma is a chronic and heterogeneous inflammatory disorder with several different phenotypes. Whereas clinical features of asthma are non-specific and pulmonary function tests are often insensitive, further development is needed for efficient treatment or even early diagnosis. Recently, several airway inflammatory biomarkers have emerged as valuable tools in diagnosis and management of asthma. The analysis of molecular markers of airways inflammation has provided promising and non-invasive techniques that facilitate the detection of disease phenotypes as well as measurement of therapeutic efficacy. Although conventional treatments remain the preferred therapy, they do not adequately control some severe cases of asthma. Novel therapeutic agents have been developed to target various biomarkers involved in the inflammatory responses and have been investigated in patients with asthma. In this article, we summarized the most studied asthma biomarkers, derived from a variety of biological sources including exhaled gases, induced sputum, serum and urine. Likewise, the effects of current anti-inflammatory asthma treatments on inflammatory biomarkers and some promising biomarkers for developing new targeted therapies are also discussed.

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Association Between Clinical Severity of Childhood Asthma and Serum Leptin Levels

Abstract: Leptin levels correlated with the clinical severity of asthma and this was suggested to be associated with the severity of inflammation in asthma. More studies are required to evaluate leptin levels in predicting asthma severity.

Cited by 14 publications

References 18 publications

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies

Leptin, adiponectin and pulmonary diseases

Biomolecular markers in assessment and treatment of asthma

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