Association Between Clinical Manifestations and Prognosis in Patients with COVID-19

Abstract

Purpose: The purpose of this study was to determine the risk factors associated with pneumonia, acute respiratory distress syndrome (ARDS), and clinical outcome among patients with novel coronavirus disease 2019 (COVID-19). Methods: This was a cross-sectional multicenter clinical study. A total of 95 patients infected with COVID-19 were enrolled. The COVID-19 diagnostic standard was polymerase chain reaction detection of target genes of 2019 novel coronavirus (2019-nCoV). Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. ARDS was defined as an oxygenation index (arterial partial pressure of oxygen/fraction of inspired oxygen) 300 mm Hg. Findings: Multivariate analysis showed that older age (odds ratio [OR], 1.078; p ¼ 0.008) and high body mass index (OR, 1.327; p ¼ 0.024) were independent risk factors associated with patients with pneumonia. For patients with ARDS, multivariate analysis showed that only high systolic blood pressure (OR, 1.046; p ¼ 0.025) and high lactate dehydrogenase level (OR, 1.010; p ¼ 0.021) were independent risk factors associated with ARDS. A total of 70 patients underwent CT imaging repeatedly after treatment. Patients were divided in a disease exacerbation group (n ¼ 19) and a disease relief group (n ¼ 51). High body mass index (OR, 1.285; p ¼ 0.017) and tobacco smoking (OR, 16.13; p ¼ 0.032) were independent risk factors associated with disease exacerbation after treatment. Implications: These study results help in the risk stratification of patients with 2019-nCoV infection. Patients with risk factors should be given timely intervention to avoid disease progression. (Clin Ther.

Older age and frailty are the chief predictors of mortality in COVID-19 patients admitted to an acute medical unit in a secondary care setting- A cohort study

“…The in uence of frailty (frailty score of 5 or more) upon mortality outweighed that of age in our cohort (MV model 3; OR 4.3; p=0.002 vs OR 1.03; p=0.10), possibly due to the distribution of frailty which affected patients as young as 65 years of age. Several studies have reported age as a risk factor associated with mortality (35)(36)(37), and our ndings are also supported by the recently published multicentre study in the United Kingdom showing a positive association between frailty and mortality (38).…”

Older age and frailty are the chief predictors of mortality in COVID-19 patients admitted to an acute medical unit in a secondary care setting- A cohort study

“…The in uence of frailty (frailty score of 5 or more) upon mortality outweighed that of age in our cohort (MV model 3; OR: 4.3; p=0.002 vs OR:1.03; p=0.10), possibly due to the distribution of frailty which affected patients as young as 65 years of age. Several studies have reported age as a risk factor associated with mortality (32)(33)(34), and our ndings are also supported by the recently published multicentre study in the United Kingdom showing a positive association between frailty and mortality (35).…”

Older Age and Frailty are the Chief Predictors of Mortality in COVID-19 Patients Admitted to an Acute Medical Unit in a Secondary Care Setting- A Cohort Study

“…The in uence of frailty (frailty score of 5 or more) upon mortality outweighed that of age in our cohort (multivariate model; OR:5.1; p < 0.001 vs OR:1.03; p = 0.03). Although several studies have reported age as a risk factor associated with mortality (26)(27)(28) the association of frailty status using the clinical frailty score has not been reported to be a predictor in COVID-19 patients to date.…”