Association between Circulating Vitamin D Level and Urolithiasis: A Systematic Review and Meta-Analysis

Hu, Henglong; Zhang, Jiaqiao; Lu, Yuchao; Zhang, Zongbiao; Qin, Baolong; Gao, Hongbin; Wang, Yufeng; Zhu, Ji; Wang, Qing; Zhu, Yunpeng; Yang, Xiufen; Wang, Shaogang

doi:10.3390/nu9030301

Cited by 43 publications

(29 citation statements)

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“…26,27 Table 1 does not include conditions where the elevation in plasma levels of 1,25(OH) 2 D is merely associated with the condition, rather than being a result of the condition. For example, elevation in 1,25(OH) 2 D is a risk factor for kidney stones, 49 and kidney stones have significant comorbidity with CD. 50 However, since there is no evidence that kidney stones cause the elevation in plasma levels of 1,25(OH) 2 D that is associated with them, 49 kidney stones are not included in Table 1.…”

Section: Conditions That Cause Elevated 125(oh) 2 D and Cd Riskmentioning

confidence: 99%

“…For example, elevation in 1,25(OH) 2 D is a risk factor for kidney stones, 49 and kidney stones have significant comorbidity with CD. 50 However, since there is no evidence that kidney stones cause the elevation in plasma levels of 1,25(OH) 2 D that is associated with them, 49 kidney stones are not included in Table 1.…”

Section: Conditions That Cause Elevated 125(oh) 2 D and Cd Riskmentioning

confidence: 99%

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<p>Elevated Levels of 1,25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease</p>

Bittker¹

2020

CEG

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The prevalence of celiac disease (CD) has increased significantly in some developed countries in recent decades. Potential risk factors that have been considered in the literature do not appear to provide a convincing explanation for this increase. This has led some researchers to hypothesize that there is a "missing environmental factor" that increases the risk of CD. Based on evidence from the literature, the author proposes that elevation in plasma levels of 1,25-dihydroxyvitamin D [1,25(OH) 2 D] is a missing risk factor for CD, and relatedly that significant oral vitamin D exposure is a "missing environmental factor" for CD. First, elevated plasma levels of 1,25(OH) 2 D are common in CD, especially in the newly diagnosed. Second, nine distinct conditions that increase plasma levels of 1,25(OH) 2 D are either associated with CD or have indications of such an association in the literature. Third, a retrospective study shows that sustained oral vitamin D supplementation in infancy is associated with increased CD risk, and other studies on comorbid conditions support this association. Fourth, large doses of oral vitamin D upregulate many of the same cytokines, chemokines, and toll-like receptors that are upregulated in CD. Fifth, epidemiological evidence, such as the timing of the inception of a CD "epidemic" in Sweden, the increased prevalence of CD in Finland and the United States in recent decades, the unusually low prevalence of CD in Germany, and the differential in prevalence between Finnish Karelians and Russian Karelians, may all be explained by oral vitamin D exposure increasing CD risk. The same is true of some seemingly contradictory results in the literature on the effects of breastfeeding on CD risk. If future research validates this hypothesis, adjustments to oral vitamin D consumption among those who have genetic susceptibility may decrease the risk of CD in these individuals.

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Section: Conditions That Cause Elevated 125(oh) 2 D and Cd Riskmentioning

confidence: 99%

Section: Conditions That Cause Elevated 125(oh) 2 D and Cd Riskmentioning

confidence: 99%

<p>Elevated Levels of 1,25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease</p>

Bittker¹

2020

CEG

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“…The impact of vitamin D supplementation (without calcium) has been studied in small prospective studies and found to be safe for the average KSF with vitamin D deficiency [105]. However, a subset of calcium stone formers may exhibit worsening hypercalciuria upon vitamin D supplementation [106]. In his presentation Dr Maalouf reviewed the epidemiology and pathophysiologic mechanisms by which calcium and vitamin D supplements impacts nephrolithiasis risk, and outlined a framework to employ when considering calcium and/or vitamin D supplementation in nephrolithiasis patients (Table 3).…”

Section: Nephrolithiasis From Vitamin D and Calcium Supplementationmentioning

confidence: 99%

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

et al. 2019

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A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. This manuscript summarizes some of the major highlights of the meeting.

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“…23 Serum vitamin D düzeyindeki yükseklik ile böbrek taşı gelişimi arasında ilişki bulunmamıştır. 24,25 Hastalarımızın günlük vitamin D alımı 25,9±10,6 (7,4) μg/gün olup kan 25(OH) vitamin D düzeyi 8 hastada >30 ng/ mL, 13 hastada 20-30 ng/mL ve 9 hastada <20 ng/mL idi. Hastalarımız arasında hiperkalsiüriye neden olacak vitamin D yüksekliği olan hasta bulunmamakta idi.…”

Section: Discussionunclassified

The Effectiveness of Ultrasonography in Detecting Emergent Pediatric Pathologies and Requirement for Additional Imaging Techniques: A Retrospective Study

Baştuğ¹

2018

cayd

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Giriş: Bu çalışmada, ev tipi ventilatör ile izlenen trakeostomili hastalarda ürolitiazis sıklığı ve risk faktörlerinin değerlendirilmesi amaçlanmıştır. Yöntemler: Ocak 2014 ve Aralık 2015 tarihleri arasında çocuk yoğun bakım ünitemize yatırılan ve ev tipi ventilatörü olan trakeostomili 30 hasta geriye dönük olarak değerlendirilmiştir. Hastalara ait yaş, cinsiyet, altta yatan hastalık, kullanmakta olduğu ilaçlar, beslenme şekli, beslenme ürünü, kan biyokimyası, parathormon, 25(OH) vitamin D düzeyi, spot idrarda kalsiyum/kreatin, üriner sistem ultrasonografisi bilgileri hastaların arşiv dosyaları ve bilgisayar sisteminden elde edilmiştir. Bulgular: Hastaların %30'u (9/30) kız, %70'i (21/30) erkek olup yaş ortanca 70 ay (15-197 ay) idi. Motor fonksiyon sınıflama sistemine göre hastaların %33,3'ü (10/30) skor 4, %66,7'si (20/30) skor 5 olup tamamı immobil hastalar idi. Üriner sistem ultrasonografisi ile hastaların %30'unda (9/30) üst üriner sistem taşı saptandı. Hastaların %56,7'sinde (17/30) spot idrar kalsiyum/kreatin 0,21'in üzerinde bulundu. Yaşa göre spot idrar kalsiyum/kreatin hastaların %66,6'sında (20/30) yüksek saptandı. Hastaların günlük kalsiyum alımı 541±182 (336-1200) mg/gün; vitamin D alımı 25, 9±10,6 (7,8-51,4) μg/gün idi. Hastaların tamamında kan kalsiyum düzeyi normal sınırlarda (8,5-10,5 mg/dL) olup kan 25(OH) vitamin D düzeyi 8 hastada >30 ng/mL, 13 hastada 20-30 ng/mL ve 9 hastada <20 ng/mL idi. Sonuç: Ev tipi ventilatör ile izlenen trakeostomili hastalarda immobilizasyon ürolitiazis açısından önemli bir risk faktörü olup bu hastaların eşlik eden metabolik bozukluklar açısından düzenli olarak takip edilmesi gerekmektedir. Anahtar Kelimeler: Çocuk, immobilizasyon, ürolitiazis, ev tipi ventilatör hastası Introduction:The aim of this study was to assess the frequency of urolithiasis and risk factors for urolithiasis in home ventilated patients with tracheostomy. Methods: We retrospectively analyzed 30 home-ventilated patients with tracheostomy who were followed up at our pediatric intensive care unit from January 2014 to December 2015. Data analyzed included age, gender, underlying disease for hospitalization, drugs, nutrition method, nutrition solution, biochemical parameters, 25(OH) vitamin D and paratyroid hormone levels, urinary calcium/creatinine ratio, and urinary ultrasonography results. Results: A total of 30 patients [9 female (30%), 21 male (70%)] with a median age of 90.06 months were evaluated in this study. According to the motor function classification system, 33.3% (10/30) of patients were class 4 and 66.7% (20/30) were class 5 and all patients were immobile. Upper urinary stone was detected with urinary ultrasonography in 30% (9/30) of patients. Urinary calcium/creatinine ratio was >0.21 in 56.7% (17/30) of patients. Age-related urinary calcium/creatinine ratio was above the normal limits in 66.6% (20/30) of patients. The mean daily calcium intake was 54±82 (336-1200) mg/day and vitamin D intake was 25.9±10.6 (7.8-51.4) μg/day. Blood calcium was normal (8.5-10.5 mg/dL) in all pati...

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Association between Circulating Vitamin D Level and Urolithiasis: A Systematic Review and Meta-Analysis

Cited by 43 publications

References 60 publications

<p>Elevated Levels of 1,25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease</p>

<p>Elevated Levels of 1,25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease</p>

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

The Effectiveness of Ultrasonography in Detecting Emergent Pediatric Pathologies and Requirement for Additional Imaging Techniques: A Retrospective Study

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