Association between Circulating Vitamin D, the Taq1 Vitamin D Receptor Gene Polymorphism and Colorectal Cancer Risk among Jordanians

Atoum, Manar; Tchoporyan, Melya Nizar

doi:10.7314/apjcp.2014.15.17.7337

Cited by 34 publications

(35 citation statements)

References 48 publications

(55 reference statements)

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“…From those papers, 14 were finally selected after reading the full articles. The reasons for excluding the remaining papers were: (1) no indication of 25(OH)D categories or risk ratios over categories [25,26,27]; (2) inclusion of patients with inflammatory bowel diseases [28]; and (3) the outcome was cancer mortality [29,30,31]. …”

Section: Resultsmentioning

confidence: 99%

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

Ekmekçioğlu

Haluza

Kundi

2017

IJERPH

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Epidemiological evidence suggests an association between low vitamin D status and risk for various outcomes including cardiovascular diseases, cancer, and type 2 diabetes mellitus (T2DM). Analyzing serum 25-hydroxyvitamin D [25(OH)D] is the most established means to evaluate an individual’s vitamin D status. However, cutoff values for 25(OH)D insufficiency as well as for optimal 25(OH)D levels are controversial. This systematic review critically summarizes the epidemiological evidence regarding 25(OH)D levels and the risk for colorectal cancer and T2DM. The meta-analytical calculation revealed a pooled relative risk (RR) of 0.62 (CI 0.56–0.70; I2 = 14.7%) for colorectal cancer and an RR of 0.66 (CI 0.61–0.73; I2 = 38.6%) for T2DM when comparing individuals with the highest category of 25(OH)D with those in the lowest. A dose–response analysis showed an inverse association between 25(OH)D levels and RR for both outcomes up to concentrations of about 55 ng/mL for colorectal cancer and about 65 ng/mL for T2DM. At still higher 25(OH)D levels the RR increases slightly, consistent with a U-shaped association. In conclusion, a higher 25(OH)D status is associated with a lower risk for colorectal cancer and T2DM; however, this advantage is gradually lost as levels increase beyond 50–60 ng/mL.

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Section: Resultsmentioning

confidence: 99%

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

Ekmekçioğlu

Haluza

Kundi

2017

IJERPH

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“…[20] Breast cancer research in the Middle East is extremely limited and genetics studies about cancer within Jordan are scarce except for few studies that screen gene polymorphism. [21222324]…”

Section: Discussionmentioning

confidence: 99%

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Atoum

Al-Khatib

2017

Chinese Medical Journal

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Background:Breast cancer is the most common type of cancer among females. Genetic polymorphisms might have a role in carcinogenesis. The aim of this study was to determine whether C to T base substitution within TaqI Vitamin D receptor (VDR) gene (rs731236) in exon 9 was a risk factor among patients with breast cancer.Methods:Peripheral blood was drawn from 122 Jordanian breast cancer patients and 100 healthy Jordanian volunteers in Al-Basheer Hospital during the summer months (from June to November of 2013, 2014, and 2015). DNA was amplified using polymerase chain reaction (PCR), followed by TaqI restriction enzyme digestion. Quantification of serum 25-hydroxy Vitamin D (25[OH]D) level was determined by competitive immunoassay Elecsys.Results:Genotypic frequencies for TaqI TT, Tt, and tt genotypes were 41%, 46%, and 13% for breast cancer compared to 42%, 50%, and 8% for control, respectively. Vitamin D serum level was significantly lower in the breast cancer patients (8.1 ± 0.3 ng/ml) compared to the control group (21.2 ± 0.6 ng/ml; P = 0.001). This study showed an inverse association between 25(OH)D serum level and breast cancer risk (odds ratio [OR], 22.72, 95% confidence interval [CI], 10.06–51.29).Conclusions:An inverse association was found between 25(OH)D serum level and breast cancer risk. Statistical difference was also found between different VDR TaqI genotypes and circulating levels of 25(OH)D among Jordanian females with breast cancer.

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“…[27,37] TaqI is one of these sites located in the 3′UTR of VDR that has been considered to be a risk factor for CRC. [33] Atoum and Tchoporyan [13] have reported that Jordanians with TaqI TT and Tt genotypes had an increased CRC risk, and Yaylim-Elaltan et al [15] indicate that a VDR gene with TTFf or TtFf genotypes appears to be protective against CRC. However, studies in New Zealand [38] and Saudi Arabian [39] found no evidences, suggesting that the TaqI polymorphisms correlated with susceptibility to CRC.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Several studies have reported that VDR polymorphisms, including TaqI , BsmI , and Tru91 , are associated with the susceptibility of CRC. [13] Many studies have focused on the association between TaqI polymorphisms and CRC with conflicting results [14,15] ; thus, the involvement of vitamin D in CRC pathogenesis remains unclear. [12,16] …”

Section: Introductionmentioning

confidence: 99%

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to colorectal cancer

2017

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The meta-analysis aimed to investigate the correlation between the polymorphism of the vitamin D receptor (VDR) TaqI and susceptibility of colorectal cancer.Studies were extracted from the electronic databases of PubMed and Embase. The balance of heredity was estimated by the Hardy–Weinberg equilibrium test, and heterogeneity was assessed by Cochran Q statistics and I2 test. Four assessed models, namely additive (t vs T), dominant (Tt + tt vs TT), recessive (tt vs Tt + TT), and codominant (Tt vs TT and tt vs TT), were used to evaluate the correlations and the effective results were measured as odds ratio (OR) with 95% confidence interval (CI).A total of 14 studies, including 4632 patients and 5086 controls, were enrolled in this meta-analysis. With no significant heterogeneities observed among the 4 models, the fixed-effect model was used to examine the pooled effect value. There were no significant differences among t vs T (OR = 1.01; 95% CI, 0.94–1.09; P = .70), Tt + tt vs TT (OR = 1.05; 95% CI, 0.96–1.15; P = .32), tt vs Tt + TT (OR = 1.01; 95% CI, 0.87–1.17; P = .92), Tt vs TT (OR = 1.03; 95% CI, 0.93–1.13; P = .62), and tt vs TT (OR = 1.00; 95% CI, 0.85–1.17; P = .98) with respect to increasing CRC frequency.No evidence showed that TaqI polymorphisms were significantly associated with susceptibility to CRC.

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Association between Circulating Vitamin D, the Taq1 Vitamin D Receptor Gene Polymorphism and Colorectal Cancer Risk among Jordanians

Cited by 34 publications

References 48 publications

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to colorectal cancer

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