Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies

Wang, Yao; Huang, Shuai; Pei, Yu

doi:10.1371/journal.pone.0225705

Cited by 16 publications

(14 citation statements)

References 34 publications

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“…In previous studies, NAFLD-related metabolic factors including BMI, HOMA-IR or DM2 were both positively [32][33][34] and negatively [13,[35][36][37] associated with circulating Nrg4 levels in humans. In line with a recent meta-analysis on circulating Nrg4 levels in diabetic patients, we observed no correlation between BMI, HOMA-IR, fasting glucose, blood triglycerides levels and plasma Nrg4 levels [26]. The clinical significance of the observed negative but weak correlation between plasma Nrg4 levels and HDL-C, in line with the finding of Chen et al in diabetic individuals, is doubtful given the unclear role of BAT function on cholesterol levels [38] and even might be the result of multiple testing error [33,34,37].…”

Section: Plos Onesupporting

confidence: 91%

“…1A). Previous reports showed that the presence of type 2 diabetes may influence the level of circulating NRG4 levels [26]. We observed no difference in plasma Nrg4 levels between NAFLD patients with DM2 (n = 16), NAFLD patients without DM2 (n = 49) and HC (n = 43) (P = 0.381) (Fig 1B).…”

Section: Baseline Characteristicsmentioning

confidence: 45%

“…Plasma Nrg4 levels were not significantly different between NAFLD patients and HC (respectively 89.2 [68.6; 102.2] vs. (89.5 [68.2; 112.2]; data expressed as median and [interquartile range (Q1, Q3)] (p = 0.622) ( Fig 1A ). Previous reports showed that the presence of type 2 diabetes may influence the level of circulating NRG4 levels [ 26 ]. We observed no difference in plasma Nrg4 levels between NAFLD patients with DM2 (n = 16), NAFLD patients without DM2 (n = 49) and HC (n = 43) (P = 0.381) ( Fig 1B ).…”

Section: Resultsmentioning

confidence: 99%

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Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

et al. 2021

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Background Neuregulin 4 (Nrg4), a novel adipokine enriched in brown adipose tissue has been observed to negatively regulate de novo hepatic lipogenesis and limit nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH) in rodents. However, the role of Nrg4 in human NAFLD remains unclear to date. We analysed Nrg4 plasma levels and its association with liver disease severity together with the transcriptional profile of the Nrg4 pathway in liver and visceral adipose tissue (VAT) of NAFLD patients. Methods Plasma Nrg4 levels were measured in 65 NAFLD patients and 43 healthy controls (HC). Hepatic steatosis and fibrosis were diagnosed and quantified with chemical shift MRI and transient elastography respectively. Furthermore, blood lipid levels, HOMA-IR and systemic pro-inflammatory cytokines (TNF-α, IL-6 and IFN-γ) were analysed. Microarray analyses to assess differences in the Nrg4 and its receptor family ErbB pathway in liver and VAT from an independent patient group with biopsy proven NAFL (simple steatosis) (n = 4), NASH (n = 5) and normal liver (n = 6) were performed. Results Plasma Nrg4 levels were not significantly different between NAFLD patients and HC (p = 0.622). Furthermore, plasma Nrg4 levels did not correlate with the hepatic fat fraction (r = -0.028, p = 0.829) and were not significantly different between NAFLD patients with or without hepatic fibrosis (p = 0.087). Finally, the expression profile of 82 genes related to the Nrg4-ErbB pathway in liver and VAT was not significantly different between NAFL, NASH or obese controls. Conclusion Our study does not support a role for Nrg4 in the pathophysiology of human NAFLD.

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Section: Plos Onesupporting

confidence: 91%

Section: Baseline Characteristicsmentioning

confidence: 45%

Section: Resultsmentioning

confidence: 99%

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Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

et al. 2021

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“… Kang et al (2016) also found increased serum levels of NRG4 in participants with overweight (mean BMI 27 ± 4.02 kg/m 2 ) and type 2 diabetes compared to participants without obesity (mean BMI 24.1 ± 2.65 kg/m 2 ). Consistently, a recent meta-analysis, in which seven studies were included, concluded that circulating NRG4 was associated with alterations in glucose metabolism and obesity ( Wang et al, 2019c ).…”

Section: Introductionmentioning

confidence: 83%

Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells

et al. 2022

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“…where r and r s represent the Pearson’s and Spearman’s CORs, respectively ( 26 ). Cochran’s Q and chi-square tests were used to examine data heterogeneity.…”

Section: Methodsmentioning

confidence: 99%

The correlation of serum/plasma IGF-1 concentrations with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression

2022

Front. Endocrinol.

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BackgroundObstructive sleep apnea hypopnea syndrome (OSAHS) is a common disease that has serious cardiovascular and metabolic effects. Insulin-like growth factor 1 (IGF-1) levels are reportedly reduced in patients with OSAHS; however, this is still a matter of debate. Therefore, we investigated the association between serum/plasma IGF-1 levels and OSAHS in this meta-analysis.MethodsWan Fang, Excerpta Medica dataBASE, Web of Science, China National Knowledge Infrastructure, VIP, PubMed, and other databases were searched for materials published in any language before April 2, 2022. Two researchers analyzed the studies for quality according to the Newcastle-Ottawa Scale. The acquired data were analyzed using Stata 11.0 and R 3.6.1 software. The effect size was estimated and calculated using standard mean differences and correlation coefficients. Moreover, a combined analysis was conducted using either a random- or fixed-effects model.ResultsUltimately, 34 studies met our inclusion criteria. Our findings revealed that the plasma/serum IGF-1 concentrations in patients with OSAHS was significantly reduced compared with those in healthy subjects. Subgroup analyses were performed according to OSAHS severity, ethnicity, age, body mass index, specimen testing method, and study design. The outcomes suggested that nearly all subgroups of patients with OSAHS had reduced serum IGF-1 levels. Disease severity and differences in ethnicity were identified as possible influencing factors of serum IGF-1 levels in patients with OSAHS in the meta-regression analysis, and no other factors were found to alter plasma/serum IGF-1 concentrations. Moreover, plasma/serum IGF-1 concentrations were negatively correlated with apnea-hypopnea index and oxygen desaturation index scores and positively associated with minimum oxygen saturation.ConclusionSerum/plasma IGF-1 concentrations in patients with OSAHS were greatly reduced compared with those of patients in the control group, and were negatively correlated with apnea-hypopnea index and oxygen desaturation index scores and positively correlated with minimum oxygen saturation.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022322738.

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Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies

Cited by 16 publications

References 34 publications

Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells

The correlation of serum/plasma IGF-1 concentrations with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression

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