Association Between Circulating Hæmoglobin Level, Serum-Cholesterol, and Blood-Pressure

Elwood, Peter Creighton; Mahler, Robert; Sweetnam, P. M.; Moore, F; Welsby, Ellana

doi:10.1016/s0140-6736(70)91627-2

Cited by 62 publications

(25 citation statements)

References 7 publications

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“…Urate, heart rate and haematocrit have all been shown to be strongly associated with both hypertension and blood lipids in several population studies. 15,16,21,[40][41][42] Although these factors have links with overweight/obesity, the associations have been shown to be independent of BMI. In the present study heart rate, urate and haematocrit appear to account for (in statistical terms) the relationship between hypertension and high triglyceride and total cholesterol.…”

Section: Insulin and Blood Pressurementioning

confidence: 99%

Hypertension, serum insulin, obesity and the metabolic syndrome

et al. 1998

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Background and aims: In recent years it has been proposed that hypertension is part of a cluster of metabolic risk factors (syndrome X) involving hyperlipidaemia and hyperglycaemia, with hyperinsulinaemia as the common link. This study has investigated: (1) the prevalence of the metabolic syndrome and its component variables and their relationship to body mass index (BMI) and non-fasting insulin levels in a general population; and (2) the distribution and clustering of metabolic variables in normotensives and hypertensives. Methods: Cross-sectional study of 5222 men aged 40-59 years with no history of coronary heart disease (CHD), diabetes mellitus or stroke drawn from general practices in 18 British towns. The men were a subgroup of the 7735 men in the British Regional Heart Study (BRHS) cohort whose baseline non-fasting serum was analysed for insulin, using a specific ELISA method. Main outcome measures: Hyperinsulinaemia, hyperglycaemia, high serum total cholesterol, high triglyceride and hyperuricaemia were defined as the top 20% of the distribution in the 5222 men. Low HDL-cholesterol was defined as the bottom 20%. Results: BMI and non-fasting insulin were both significantly and strongly associated with non-diabetic hyperglycaemia, lipid abnormalities (HDL-cholesterol, triglyceride and total cholesterol) and hyperuricaemia. BMI was strongly associated with hypertension whereas

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Section: Insulin and Blood Pressurementioning

confidence: 99%

Hypertension, serum insulin, obesity and the metabolic syndrome

et al. 1998

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“…Anemia, even when mild, is associated with low serum cholesterol [1][2][3]. In the Framingham study, subjects with a hemoglobin concentration below the group median had a stroke rate less than half that in subjects with hemoglobin concentration above the median [4].…”

Section: Introductionmentioning

confidence: 99%

Arteriosclerotic events are less frequent in persons with chronic anemia: Evidence from families with hereditary spherocytosis

2006

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Because anemic persons have lower cholesterol and whole blood viscosity than those who are not anemic, we hypothesized that subjects with hereditary spherocytosis who have not had the spleen removed should have fewer arteriosclerotic events than unaffected family members. We defined arteriosclerotic events as myocardial infarct, stroke, coronary artery surgery, and carotid artery surgery. We compared the rate of these events in affected-not splenectomized persons to the rate in unaffected family members. The relative risk of an arteriosclerotic event in hereditary spherocytosis patients with a spleen was one fifth that in unaffected family members. These data support the hypothesis that chronic anemia retards the development of arteriosclerosis. Spherocytosis is another example of an inherited condition that conveys an advantage in one system and a disadvantage in another. Am. J. Hematol. 81:315-317, 2006. V V C 2006 Wiley-Liss, Inc.

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“…Indeed, as Asai et al [1] reported, the difference in lipid levels between splenectomized and sham-operated animals apparently was changed depending on the post-operative time. (3) Although it has been suggested that anemia is associated with hypocholesterolemia [6,14], Dh/+ mice are not anemic, in contrast to splenectomized mice [9]. Therefore, it is unlikely that the anemia is the primary cause of hypolipidemic trends in Dh/+.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Consequence of Congenital Asplenia Caused by the Dominant hemimelia Mutation in Mice

Suto

2009

The Journal of Veterinary Medical Science

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ABSTRACT. The potential roles of the spleen in lipid metabolism have been debated for the last 2 decades. Although there are some discrepancies among investigations, they are in agreement on the point that the spleen has roles in lipid metabolism. In the present study, role of the spleen in lipid metabolism was investigated by use of a hereditary asplenic mouse strain carrying a Dominant hemimelia (Dh) mutation. In studies on females, asplenic mice (Dh/+) had significantly lower plasma high-density lipoprotein-cholesterol (HDL-CHO) levels than did eusplenic mice (+/+) on a chow diet. On a high-fat diet, Dh/+ had significantly higher HDL-CHO than did +/+. In studies on Y-consomic strains (DH-Chr Y), DH-Chr Y-Dh/+ had significantly lower values than did DH-Chr Y-+/+ for all traits. For body weight and HDL-CHO, there were significant differences in mean trait values among DH-Chr Y-+/+, suggesting that Y-linked genes affect these traits. Furthermore, pattern of distribution of mean trait values among Y-consomic strains largely differed between DH-Chr Y-+/+ and DH-Chr Y-Dh/+, suggesting the presence of interaction between Dh and Y-linked genes. The present study shows that Dh has effects on lipid metabolism. Although Dh has multiple phenotypic effects it is possible that the change in lipid levels is affected in part by the absence of the spleen. KEY WORDS: asplenic mouse, Dominant hemimelia (Dh), plasma lipid levels, Y-consomic strains.

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Association Between Circulating Hæmoglobin Level, Serum-Cholesterol, and Blood-Pressure

Cited by 62 publications

References 7 publications

Hypertension, serum insulin, obesity and the metabolic syndrome

Hypertension, serum insulin, obesity and the metabolic syndrome

Arteriosclerotic events are less frequent in persons with chronic anemia: Evidence from families with hereditary spherocytosis

Metabolic Consequence of Congenital Asplenia Caused by the Dominant hemimelia Mutation in Mice

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