Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study

Cochrane, Andy; Robertson, Ian H.; Coogan, Andrew N.

doi:10.1007/s00702-012-0802-2

Cited by 40 publications

(42 citation statements)

References 30 publications

(30 reference statements)

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“…Various studies have shown that AD may be associated with circadian rhythms (Gritton et al, 2009;Cochrane et al, 2012). Our previous studies confirmed AD patients exhibit disorders in the circadian rhythm of arterial blood pressure or thyroid-stimulating hormone levels; additionally, polymorphisms in the CLOCK gene, including rs4580704 C/G, rs1554483 G/C, and 3111T/C, were associated with the susceptibility to AD (Chen et al, 2013a,b,c,d;Yang et al, 2013).…”

Section: Introductionsupporting

confidence: 51%

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

Chen¹,

Peng²,

Cq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 unrelated AD patients and 423 control subjects were included. Both in the entire sample and in APOE e4 non-carriers, the prevalence of T carriers in BMAL1 rs2278749 T/C in AD patients was significantly higher than that in control subjects (entire sample: χ 2 = 12.950, P < 0.0001; APOE e4 non-carriers: χ 2 = 13.094, P < 0.0001). Both in the entire sample and in APOE e4 non-carriers, the prevalence of TT genotypes 2278749 in AD patients was also significantly higher than that in control subjects (entire sample: χ 2 = 7.765, P = 0.024; APOE e4 non-carriers: χ 2 = 13.062, P < 0.0001). However, among APOE e4 carriers, the difference 18516 Q. Chen et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18515-18522 (2015) in the prevalence of T carriers or TT genotypes in the BMAL1 rs2278749 T/C between patients and control subjects presents was not significant (T carriers: χ 2 = 0.078, P = 0.851 or TT genotypes: χ 2 = 2.576, P = 0.325). Among APOE e4 non-carriers, T carriers in the BMAL1 rs2278749 T/C were associated with a high susceptibility to AD, but among APOE e4 carriers, the association between AD and BMAL1 rs2278749 T/C was not significant.

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Section: Introductionsupporting

confidence: 51%

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

Chen¹,

Peng²,

Cq³

et al. 2015

Genet. Mol. Res.

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“…This left us with 55 full-text articles to evaluate for eligibility, of which 18 studies examined sleep characteristics other than sleep duration in relation to cognitive function [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] , and 6 studies were based on duplicate study populations [44][45][46][47][48][49] ; there were 31 remaining studies that were eligible for inclusion (Eligibility Phase). One additional study was identified based on a review of the bibliographies from these manuscripts [50] ; thus, in total, 32 studies were included in our review [16, (Inclusion Phase).…”

Section: Methodsmentioning

confidence: 99%

“…These studies ranged in size from 26 to 32,142 participants, and were conducted across multiple countries: United States [53, 55-57, 67, 70, 72, 73, 75, 79] , United Kingdom [61,64,77] , Spain [58,69] , Finland [50,68] , France [54,62] , Japan [65,78] , Australia [52] , Germany [59] , Ireland [16] , Netherlands [80] , Hong Kong [66] , Canada [63] , Korea [60] , China [76] , Singapore [71] . There was also a multi-country study incorporating data from China, Ghana, India, South Africa, Russia, and Mexico [74] ; the location of one study was unknown [51] .…”

Section: Description Of Studies Included In Our Reviewmentioning

confidence: 99%

“…Most studies included both women and men [16, 50, 51, 54, 56-69, 71, 72, 74, 76-80] , although some studies focused on women only [55,70,73] or men only [53,75] ; 1 study did not specify the sex of participants [52] . Studies generally specified age thresholds for participants at the time of first cognitive interview: ≥ 30 years [50] , ≥ 45 years [80] , ≥ 50 years [74, 76,77] , ≥ 55 years [16] , ≥59 years [71], ≥ 60 years [54,58,60,65] , ≥ 65 years [55, 62-64, 66, 68, 69, 75] , ≥68 years [70], and ≥ 70 years [59,73,79] . Other studies provided the mean age [67] or age ranges [51-53, 56, 57, 61, 72, 78] of their participants, but did not explicitly describe an age threshold as part of the inclusion criteria; regardless, older adults were eligible for all studies.…”

Section: Study Populationmentioning

confidence: 99%

“…Small studies of emergency-room physicians and airline crews have dem-onstrated that circadian disruption and related sleep problems can lead to short-term decrements in cognitive function [12][13][14] ; however, it remains unclear whether these exposures are detrimental for the general population or whether they influence longer-term cognition. In older adults, initial studies suggest that aberrant circadian rhythms may be related to poorer cognition [15][16][17][18] and bright-light therapy may improve cognitive impairment in Alzheimer's disease [19] , further supporting a link between circadian disruption and later-life cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

2016

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Context: Increasing evidence suggests that circadian and sleep parameters influence cognitive function with aging. Objective: To evaluate observational studies of sleep duration and cognition in older adults. Data Sources: A systematic review of OVID Medline and PsycINFO through September 2015, and review of bibliographies from studies identified. Study Selection: English-language articles reporting observational studies of sleep duration and cognitive function in older populations. Data Extraction: Data extraction by 2 authors using predefined categories of desired information. Results: Thirty-two studies met our inclusion criteria, with nearly two-thirds published in the past 4 years. One-third of studies indicated that extreme sleep durations were associated with worse cognition in older adults. More studies favored an association with long vs. short sleep durations (35 vs. 26% of studies, respectively). Four studies found that greater changes in sleep duration over time were related to lower cognition. Study design and analytic methods were very heterogeneous across studies; therefore, meta-analysis was not undertaken. Limitations: We reviewed English-language manuscripts only, with a qualitative summary of studies identified. Conclusions and Implications of Key Findings: Observational studies of sleep duration and cognitive function in older adults have produced mixed results, with more studies suggesting that long (rather than short) sleep durations are related to worse cognition. Studies more consistently indicate that greater changes in sleep duration are associated with poor cognition. Future studies should be prospectively designed, with objective sleep assessment and longer follow-up periods; intervention studies are also needed to identify strategies for promoting cognitive health with aging.

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Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

2022

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Disruptions in circadian rhythms can occur in healthy aging; however, these changes are more severe and pervasive in individuals with age‐related and neurodegenerative diseases, such as dementia. Circadian rhythm alterations are also present in preclinical stages of dementia, for example, in patients with mild cognitive impairments (MCI); thus, providing a unique window of opportunity for early intervention in neurodegenerative disorders. Nonetheless, there is a lack of studies examining the association between relevant changes in circadian rhythms and their relationship with cognitive dysfunctions in MCI individuals. In this review, circadian system alterations occurring in MCI patients are examined compared to healthy aging individuals while also considering their association with MCI neurocognitive alterations. The main findings are that abnormal circadian changes in rest‐activity, core body temperature, melatonin, and cortisol rhythms appear in the MCI stage and that these circadian rhythm disruptions are associated with some of the neurocognitive deficits observed in MCI patients. In addition, preliminary evidence indicates that interventions aimed at restoring regular circadian rhythms may prevent or halt the progress of neurodegenerative diseases and mitigate their related cognitive impairments. Future longitudinal studies with repeated follow‐up assessments are needed to establish the translational potential of these findings in clinical practice.

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Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study

Cited by 40 publications

References 30 publications

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

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