Association between cigarette smoking and impaired clinical symptoms in systemic sclerosis: A review

Zhang, Yanjie; Zhang, Li; Huang, Xiaolei; Duan, Yu; Yang, Lijuan; Wang, Jing

doi:10.1016/j.cellimm.2017.04.002

Cited by 16 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Smoking can act as an exacerbating factor, where it increases morbidity and mortality of SSc patients by worsening digital ulcers, 80 gastrointestinal symptoms, 81 pulmonary function, and increasing the likelihood of lung cancer, 82 but evidence of smoking as a disease trigger is limited. 83 De Decker et al observed a higher proportion of smokers among SSc patients exposed to silica and/or solvents, indicating that smoking might be a confounding factor or might provide a synergistic effect when combined with other toxins.…”

Section: Smokingmentioning

confidence: 99%

See 1 more Smart Citation

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

Importance Systemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression. Objective In this manuscript we provide a summary of all investigated potential external risk factors for SSc. Data sources A literature search in PubMed and EMBASE database was performed for studies published until January 1, 2020 by 2 reviewers (EN and LO) independently. Findings Occupational and/or environmental exposures to silica and organic solvents are associated with increased incidence and severity of SSc. Exposure to epoxy resins, asbestos, and particulate air pollution favors increased risk of SSc, but data are based on limited number of observational studies. There is insufficient evidence to conclude an association between SSc development and other occupational (eg, welding fumes) or personal exposures (eg, smoking, vitamin D deficiency). Association of SSc with silicone breast implants has been disproven. Infectious pathogens (eg, Helicobacter pylori and angiotropic viruses) and dysbiosis seem to play a role in SSc development and severity, but their role remains to be clarified. Conclusions and relevance It may be prudent to counsel our patients with SSc (or those at risk of SSc) to avoid occupations with exposure to silica, organic solvents, asbestos and epoxy resins; restraint from smoking, using cocaine or drugs with pro-fibrotic potential. While the association between low vitamin D and SSc remains to be confirmed, we believe that SSc patients should be encouraged to maintain healthy vitamin D levels as benefits outweigh the risks.

show abstract

Section: Smokingmentioning

confidence: 99%

“…28 More studies accounting for confounding factors such as educational level, socioeconomic status, and alcohol consumption are needed. 82…”

Section: Exposures With Probable Association (Level III Evidence)mentioning

confidence: 99%

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hypoxia and oxidative stress have been implicated in the pathophysiology of its generalized microangiopathy and fibrosis . Although smoking does not appear to confer a risk for SSc development , it has vasoconstrictive effects and increases free‐radical exposure, and together with other proinflammatory and immunomodulatory effects may exacerbate SSc manifestations . Data on the role of tobacco exposure with regard to the severity of SSc organ manifestations and progression are, however, scarce, and at times contradictory .…”

mentioning

confidence: 99%

Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study

Jaeger¹,

Valentini

Hachulla

et al. 2018

Arthritis & Rheumatology

View full text Add to dashboard Cite

show abstract

“…First, the NHIRD does not include personal information regarding lifestyles, body mass index values, smoking, and alcohol use. Smoking currently is still not clarified as a certain risk factor of SSc [ 38 ]. In order to minimize these biases, we had adjusted COPD and comorbidities to proxy these lifestyle-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between Appendicitis and Incident Systemic Sclerosis

Yang

Wei

Chang

et al. 2021

JCM

View full text Add to dashboard Cite

Objective: This nationwide study aimed to investigate the association between newly diagnosed systemic sclerosis (SSc) and previous appendicitis history. Methods: A total of 1595 patients who were newly diagnosed with SSc were recruited as the SSc cases from the 2003 to 2012 claims data of the entire population in Taiwan. The other 15,950 individuals who had never been diagnosed with SSc during 2003 and 2012 were selected as the non-SSc controls to match the SSc cases. We defined that the index date as the first date of SSc diagnosis of SSc cases and the first date of ambulatory visit for any reason of non-SSc controls. Conditional logistic regression analysis was applied for the association between appendicitis and the risk of the incident SSc, tested by estimating odds ratios (ORs) with 95% confidence intervals (CIs). Potential confounders, including the Charlson comorbidity index (CCI), a history of periodontal disease, salmonella infection, and intestinal infection, were controlled. We further designed sensitivity analyses by varying the definition of appendicitis according to the status of receiving primary appendectomy. Results: The mean age was 51 years in the case and control groups. Females accounted for 77.5%. A total of 17 (1.1%) out of 1595 SSc cases and 81 (0.5%) out of 15,950 non-SSc controls had a history of appendicitis before the index date had a history of appendicitis. A significant association between appendicitis and the risk of SSc was confirmed (OR, 2.03; 95% CI, 1.14–3.60) after adjusting potential confounders. CCI ≥ 1 (OR, 8.48; 95% CI, 7.50–9.58) and periodontal disease (OR, 1.55; 95% CI, 1.39–1.74) were also significantly associated with the risk of SSc. The association between appendicitis and SSc risk remained robust using various definitions of appendicitis. Conclusion: Our study demonstrated appendicitis was associated with the incident SSc. CCI ≥ 1 and periodontal disease also contributed to the risk of developing SSc.

show abstract

Association between cigarette smoking and impaired clinical symptoms in systemic sclerosis: A review

Cited by 16 publications

References 59 publications

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study

Association between Appendicitis and Incident Systemic Sclerosis

Contact Info

Product

Resources

About