Association between chronic psychoactive substances use and systemic inflammation: A systematic review and meta-analysis

Doggui, Radhouene; Elsawy, Wafaa; Conti, Aldo Alberto; Baldacchino, Alex

doi:10.1016/j.neubiorev.2021.02.031

Cited by 18 publications

(16 citation statements)

References 70 publications

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“…It is worth noting that individuals who drank alcohol or smoked cigarettes were not excluded from this study given the high prevalence of these conditions found in MUD ( Rommel et al., 2015 ). Taking the effects of alcohol and nicotine on gut microbiota ( Wannamethee et al., 2005 ; Leclercq et al., 2014 ; Ames et al., 2020 ) and systemic inflammation system ( Wannamethee et al., 2005 ; Barr et al., 2016 ; Sureshchandra et al., 2019 ; Doggui et al., 2021 ) into consideration, these factors would be included as possible confounders in data analysis.…”

Section: Methodsmentioning

confidence: 99%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of Collinsella, Odoribacter and Megasphaera and lower levels of Faecalibacterium, Blautia, Dorea and Streptococcus were detected in subjects with MUD. More importantly, altered fecal microbiota was found to be correlated with plasma levels of CRP, IL-2, IL-6 and IL-10. The order Lactobacillales, exhibiting lower abundance in participants with MUD, was positively related to the duration of methamphetamine abstinence and the plasma level of anti-inflammatory cytokine IL-10. This study is the first to provide evidence for a link between altered fecal microbiota and systemic inflammation in MUD. Further elucidation of interactions between gut microbiota and the host immune system may be beneficial for the development of novel therapeutic approaches for MUD.

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Section: Methodsmentioning

confidence: 99%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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“…In addition, subjects with Alcohol Use Disorders (AUD) show a worse postoperative recovery, a poor response to vaccination or a slower recovery from infections [ 81 ]. CHD alters innate and adaptive immune responses [ 82 , 86 ] and can affect a large number of systems through them, since this type of consumption has been associated with damage to different tissues such as pancreas, liver, gut, circulatory system or nervous system [ 87 ], and there are several studies that attribute, at least in part, a role of persistent systemic and local inflammation in these conditions [ 88 ].…”

Section: Effects Of Alcohol On Immune System: Putting All the Pieces Togethermentioning

confidence: 99%

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Calleja‐Conde

Echeverry‐Alzate

Bühler

et al. 2021

IJMS

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The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.

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“…46 A recent metaanalysis did not show a significant effect of cannabinoids on IL-6 after chronic cannabis use, in spite of it is believed that these drugs are protective against inflammation and seems to actively reduce the IL-6 in macrophages. 47 It has neither been seen any alteration in inflammatory markers when first-episode psychosis patients who were cannabis users were studied. 48 Nonetheless, our data showing that cannabis use disorder decrease IL-6 levels in schizophrenia subjects are in line with the few available studies suggesting that cannabis use reduces IL-6 levels.…”

Section: Discussionmentioning

confidence: 99%

Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients

et al. 2022

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Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5‐HT2AR) have been involved in psychosis and, like Akt kinase, are known to be modulated by THC. Likewise, endocannabinoid system dysregulation has been suggested in schizophrenia. The presence of these molecules in blood makes them interesting targets, as they can be evaluated in patients by a minimally invasive technique. The aim of the present study was to evaluate 5‐HT2AR protein expression and the Akt functional status in platelet homogenates of subjects diagnosed with schizophrenia, cannabis use disorder, or both conditions, compared with age‐ and sex‐matched control subjects. Additionally, endocannabinoids and pro‐inflammatory interleukin‐6 (IL‐6) levels were also measured in the plasma of these subjects. Results showed that both platelet 5‐HT2AR and the active phospho (Ser473)Akt protein expression were significantly increased in schizophrenia subjects, whereas patients with a dual diagnosis of schizophrenia and cannabis use disorder did not show significant changes. Similarly, plasma concentrations of anandamide and other lipid mediators such as PEA and DEA, as well as the pro‐inflammatory IL‐6, were significantly increased in schizophrenia, but not in dual subjects. Results demonstrate that schizophrenia subjects show different circulating markers pattern depending on the associated diagnosis of cannabis use disorder, supporting the hypothesis that there could be different underlying mechanisms that may explain clinical differences among these groups. Moreover, they provide the first preliminary evidence of peripherally measurable molecules of interest for bigger prospective studies in these subpopulations.

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Association between chronic psychoactive substances use and systemic inflammation: A systematic review and meta-analysis

Cited by 18 publications

References 70 publications

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

The Immune System through the Lens of Alcohol Intake and Gut Microbiota

Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients

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