2020
DOI: 10.1002/ijc.32971
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Association between chronic pancreatitis and pancreatic cancer: A 10‐year retrospective study of endoscopically treated and surgical patients

Abstract: Pancreatic cancer (PC) has a poor prognosis. Chronic pancreatitis (CP) associates with high morbidity and mortality, and serves as a risk factor for PC. Our study aimed to assess the association between endoscopically treated CP patients and PC, and to establish the rate of CP among patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). We retrospectively analyzed 458 CP patients undergoing endoscopic treatment (ET) between 2000 and 2010 and 349 PDAC patients undergoing pancreatic resection b… Show more

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Cited by 20 publications
(14 citation statements)
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“…It is hypothesised that progression to PC from precancerous non-invasive lesions may take 17 months to 10 years [ 10 ], providing a potentially long window for early detection or possible prevention. In particular, well-established risk factors such as diabetes or chronic pancreatitis are first identified in PC patients during the 2 to 3 years window prior to PC diagnosis [ 6 , 9 , 11 ]. The long latency period of PC often follows with rapid deterioration within a space of few months [ 12 ], yet studies suggest the tumour remains resectable in asymptomatic patients as late as 6 months before the clinical diagnosis [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is hypothesised that progression to PC from precancerous non-invasive lesions may take 17 months to 10 years [ 10 ], providing a potentially long window for early detection or possible prevention. In particular, well-established risk factors such as diabetes or chronic pancreatitis are first identified in PC patients during the 2 to 3 years window prior to PC diagnosis [ 6 , 9 , 11 ]. The long latency period of PC often follows with rapid deterioration within a space of few months [ 12 ], yet studies suggest the tumour remains resectable in asymptomatic patients as late as 6 months before the clinical diagnosis [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…In our study, all imaging tests of the patients, as well as diagnostic codes, were reviewed to nd de nite CP. A few previous studies evaluated only patients who underwent surgery or endoscopic management for CP 3,9 . These patients had complicated CPs and were followed up well.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, alcohol consumption and smoking, both well-known risk factors for PDAC, form important confounding factors as patients with CP often have a history of alcohol- and nicotine abuse[ 26 ]. Other risk factors are older age at disease onset, obesity, concurrent DM and pancreatic duct dilatation[ 27 , 28 ].…”
Section: Cp and Pancreatic Cancermentioning
confidence: 99%