Association between Chronic Obstructive Pulmonary Disease and Lung Cancer: A Case-Control Study in Southern Chinese and a Meta-Analysis

Wang, Hui; Yang, Lei; Zou, Linnan; Huang, Dongsheng; Guo, Yuan; Pan, Mingan; Tan, Yigang; Zhong, Haibo; Ji, Weidong; Ran, Pixin; Zhong, Nanshan; Lü, Jiachun

doi:10.1371/journal.pone.0046144

Cited by 45 publications

(33 citation statements)

References 73 publications

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“…63,64 Finally, chronic obstructive pulmonary disease (COPD) which is an accelerated decline in lung functioning, is highly related to LC . 65–66 Moreover, COPD is also a risk factor for CVD events such as heart failure. 62,66 In sum, LC is reported to be related to a number of CVD risk factors including hypertension, diabetes, angina, MI, stroke, AFib, COPD, and smoking.…”

Section: Cardiovascular (Cvd) Factors and Lcmentioning

confidence: 99%

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Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation

Husaini

Levine

Lammers

et al. 2017

family med commun hlth

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Objective The role of smoking and depression relative to hospital cost for lung cancer (LC) remains unknown. Methods We extracted data on depression, smoking history, demographics, and hospital charges on patients with respiratory cancers (ICD-9 codes 161–163,165) from the 2008 Tennessee Hospital Discharge Data System. The sample (n=6,665) was mostly white (86%) and male (57). Age-adjusted rates were developed per CDC methodology, and hospital costs were compared for LC with vs. without depression and smoking. Results Three findings (p<.001) emerged: (i) LC rate was higher among blacks than whites, and higher among males than females; (ii) While 66% of LC smoked (more males than females without racial variation), 24% had depression (more females and whites were depressed); (iii) The LC hospital cost was 54% higher compared to non-LC, and this cost doubled for LC with depression and smoking vs. those without such characteristics. Conclusion While LC is more prevalent among blacks and males, depression is higher among female and white patients. Since depression with higher costs existed among LC patients, our findings point to: (i) possibility of cost savings by diagnosing and treating depression among LC, and (ii) implementing proven smoking cessation programs to reduce LC morbidity and hospital costs.

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Section: Cardiovascular (Cvd) Factors and Lcmentioning

confidence: 99%

“…65–66 Moreover, COPD is also a risk factor for CVD events such as heart failure. 62,66 In sum, LC is reported to be related to a number of CVD risk factors including hypertension, diabetes, angina, MI, stroke, AFib, COPD, and smoking.…”

Section: Cardiovascular (Cvd) Factors and Lcmentioning

confidence: 99%

Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation

Husaini

Levine

Lammers

et al. 2017

family med commun hlth

View full text Add to dashboard Cite

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“…Cigarette smoking is a common risk factor for NSCLC and COPD. COPD is thought to increase the risk of lung cancer [10] and is even considered an independent risk factor [11]. Patients diagnosed with lung cancer often experience COPD symptoms [12].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics provide new insights on lung cancer staging and discrimination from chronic obstructive pulmonary disease

Deja

Porębska

Kowal

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

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“…The amount of smoking was evaluated as pack-years (pack-year = number of packs per day × years of smoking). A cut-off of 20 pack-years was set to define heavy smokers [14,25,26]. …”

Section: Methodsmentioning

confidence: 99%

Risk and Protective Factors for Small Intestine Neuroendocrine Tumors: A Prospective Case-Control Study

et al. 2015

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Background: The incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, but few studies have investigated risk factors for their occurrence, suggesting that family history (FH) of any cancer, smoking and previous cholecystectomy are associated with an increased risk. Such studies investigated small series or examined cancer registries without direct interviews. Aim: We therefore aimed at clarifying risk and protective factors for the occurrence of sporadic SI-NETs. Subjects and Methods: We performed a multicenter case-control study. Patients with a histologic diagnosis of SI-NETs were prospectively evaluated, excluding familial syndromes. Controls with non-neoplastic/non-chronic disorders seen at gastrointestinal outpatients clinics were matched for sex and age (4:1). All subjects were directly interviewed by means of a specific questionnaire on potential risk and protective factors. Cases and controls were compared by Fisher's test or Student's t test for categorical or continuous variables. Explanatory variables were analyzed by simple logistic regression analysis. A multiple logistic regression analysis was performed with an Enter model; p < 0.05 was considered significant. Results: 215 SI-NET patients and 860 controls were enrolled. FH of colorectal cancer (CRC) (8.8 vs. 5.0%) and breast cancer (10.2 vs. 4.8%), heavy smoking (24.7 vs. 14.8%) and drinking >21 alcohol units per week (7.4 vs. 3.8%) were all significantly more frequent in SI-NET patients than in controls. Multivariate analysis showed that FH of CRC (OR 2.23, 95% CI 1.29-3.84, p = 0.003), FH of breast cancer (OR 2.05, 95% CI 1.13-3.69, p = 0.01) and smoking (OR 1.47, 95% CI 1.07-2.03, p = 0.01) and in particular heavy smoking (OR 1.94, 95% CI 1.29-3.84, p = 0.0008) were associated with an increased risk for carcinoid occurrence, while use of aspirin can be considered a protective factor (OR 0.20, 95% CI 0.06-0.65, p = 0.008). Conclusion: FH of colorectal and breast cancer as well as smoking seem to be risk factors for the development of SI-NETs, while use of aspirin might be a protective factor. These factors partially overlap with those associated with CRC, but are different from those previously associated with pancreatic neuroendocrine tumors. These findings may suggest that the mechanisms of carcinogenesis for endocrine cells in different sites can be specific and similar to those of their exocrine counterparts.

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Association between Chronic Obstructive Pulmonary Disease and Lung Cancer: A Case-Control Study in Southern Chinese and a Meta-Analysis

Cited by 45 publications

References 73 publications

Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation

Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation

Metabolomics provide new insights on lung cancer staging and discrimination from chronic obstructive pulmonary disease

Risk and Protective Factors for Small Intestine Neuroendocrine Tumors: A Prospective Case-Control Study

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