Association between chronic Helicobacter pylori infection and acute ischemic stroke: Fukuoka Harasanshin Atherosclerosis Trial (FHAT)

Sawayama, Yasunori; Ariyama, Iwao; Hamada, Masanori; Otaguro, Shigeru; Machi, Takao; Taira, Yohsuke; Hayashi, Jun

doi:10.1016/j.atherosclerosis.2004.08.025

Cited by 81 publications

(66 citation statements)

References 20 publications

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“…This is in agreement with the previous reports which indicated higher seropositivity in an older population (3,11,16,24). Sung et al (16) who analyzed the seropositivity rate in different age groups of Korean adults found the highest seropositivity rate in participants over 50 and the lowest in subjects younger than 30 years, and also that HP se ro positive participants were significantly older than those sero negative (p<0.05).…”

Section: Discussionsupporting

confidence: 92%

“…In the past few years, many studies have indicated that atherosclerosis is associated with several infectious pathogens, including Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus and herpes simplex virus (1)(2)(3)(4)(5)(6)(7)(8). There has been increasing evidence that inflammation and infection could alter some atherogenic vascular factors involved in the development of atherosclerosis and its complications.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have suggested that chronic HP infection may be associated with an increase of the atherogenic risk (2,3,8,11) and several possible mechanisms of this relationship have been repor ted. Proposed mechanisms involving HP in the atherogenesis are production of excessive amounts of proinflammatory factors (such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a)) (8) and acute phase reactants (such as fibrinogen and C reactive protein) (12), cross-mimicry between HP and host pro teins (13), immunomediated vascular damage and endothelial dysfunction (2), modifying the serum lipid profile (14) and promotion of the oxidation of LDL-cholesterol (15), abnormalities in haemostasis (9), hyperhomocysteinemia, direct bacterial invasion of atherosclerosis plaques, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Proposed mechanisms involving HP in the atherogenesis are production of excessive amounts of proinflammatory factors (such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a)) (8) and acute phase reactants (such as fibrinogen and C reactive protein) (12), cross-mimicry between HP and host pro teins (13), immunomediated vascular damage and endothelial dysfunction (2), modifying the serum lipid profile (14) and promotion of the oxidation of LDL-cholesterol (15), abnormalities in haemostasis (9), hyperhomocysteinemia, direct bacterial invasion of atherosclerosis plaques, etc. Recently, it has been hypothesized that only certain HP strains, which express the cytotoxin-associated gene A (Cag A) encoding the Cag A protein, may have a link with atherosclerosis (3,9), but this is still controversial (11).…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

Kojić-Damjanov¹,

Đerić²,

Eremić³

et al. 2009

Journal of Medical Biochemistry

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Kratak sadr`aj: Podaci o proaterogenim promenama lipidskog statusa u sklopu hroni~ne Helicobacter pylori (HP) infekcije su kontradiktorni. Cilj istra`ivanja bio je da se ispitaju razlike u nekim lipidskim parametrima izme|u 55 osoba oba pola s hroni~nom HP infekcijom (IgG >50 U/mL i IgA <20 U/mL) i 55 HP seronegativnih osoba (IgG i IgA <20 U/mL) oba pola. Serumske koncentracije ukupnog holesterola (TC) (p<0,001), triglicerida (TG) (p<0,05), LDL-holesterola (LDL-C) (p<0,02), non-HDL-holesterola (non-HDL-C), apolipoproteina (apo) B (p<0,001), Lp(a) i HDL-holesterola (HDL-C) bile su vi{e kod HP seropozitivnih u odnosu na seronegativne osobe, dok gotovo da nije bilo razlika u nivoima apo A-I. Kod HP seropozitivnih osoba, u~estalost patolo{kih TC (p<0,001), TG (p<0,05), LDL-C (p<0,01), non-HDL-C (p<0,01), apo B (p<0,02) i Lp(a) vrednosti bila je vi{a u odnosu na seronegativne. Ustanovljena je negativna korelacija serum skih titara HP IgG antitela s TC, LDL-C (p<0,05), non-HDL-C, apo B i Lp(a), a pozitivna s TG, HDL-C i apo A-I nivoima. Rezultati su sli~ni za oba pola. Na{i rezultati idu u prilog hipotezi da bi hroni~na HP infekcija mogla da modifikuje lipidske parametre na proate rogeni na~in.Klju~ne re~i: ateroskleroza, Helicobacter pylori, lipidi, aterogeni rizik Summary: Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C) (p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDL-C (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

Kojić-Damjanov¹,

Đerić²,

Eremić³

et al. 2009

Journal of Medical Biochemistry

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“…A prospective analysis of data from the National Health and Nutrition Examination Survey III showed an inverse association between H. pylori and stroke mortality, with a hazard ratio of 0.69 (0.44 -1.08) for individuals infected with H. pylori 13) . A case-control study found that chronic H. pylori infection was significantly associated with increased risk of ischemic stroke in Japanese, with an OR of 2.57 (1.09 -6.08) for all subtypes combined 21) . In contrast, our nested case-control study did not show any significant associations between H. pylori and subtypes of stroke, including subarachnoid hemorrhage, cerebral hemorrhage, and cerebral infarction (data not shown).…”

Section: Discussionmentioning

confidence: 99%

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Lin

Obata

Kikuchi

et al. 2015

J Atheroscler Thromb

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Aim: An increasing number of studies have linked Helicobacter pylori (H. pylori) infection to extragastric diseases; however, the role of H. pylori in the pathogenesis of cardiovascular disease (CVD) remains controversial. We examined the association between H. pylori infection and risk of death from coronary heart disease (CHD) and stroke in a nested case-control study within a large prospective cohort study of Japanese subjects. Methods: The cases were 627 subjects who died from CHD and stroke during the follow-up period until December 31, 2003, and 627 control subjects were selected and matched to cases on sex, age, and area. Commercial immunoassay IgG enzyme-linked immunosorbent assay kits were used for the determination of the seropositivity for H. pylori. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model. Conclusion:The results of this nested case-control study suggest that there is no association between H. pylori infection and CHD and stroke mortality risk in otherwise healthy, elderly Japanese individuals.

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Infectious Burden and Risk of Stroke

et al. 2010

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To determine the association between a composite measure of serological test results for common infections (Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) and stroke risk in a prospective cohort study. Design: Prospective cohort followed up longitudinally for median 8 years.Setting: Northern Manhattan Study.Patients: Randomly selected stroke-free participants from a multiethnic urban community.Main Outcome Measure: Incident stroke and other vascular events.Results: All 5 infectious serological results were available from baseline samples in 1625 participants (mean [SD] age, 68.4 [10.1] years; 64.9% women). Cox proportional hazards models were used to estimate associations of each positive serological test result with stroke.

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Association between chronic Helicobacter pylori infection and acute ischemic stroke: Fukuoka Harasanshin Atherosclerosis Trial (FHAT)

Cited by 81 publications

References 20 publications

The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Infectious Burden and Risk of Stroke

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