Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs

Glickman, Lawrence T.; Glickman, Nita W.; Moore, George E.; Lund, Elizabeth M.; Lantz, Gary C.; Pressler, Barrak M.

doi:10.1016/j.prevetmed.2011.01.011

Cited by 64 publications

(75 citation statements)

References 16 publications

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“…In the present study, we found no correlation between severity of disease and urea or creatinine, nor any effect of treatment. These findings are surprising, because a study of the post mortem findings in 44 dogs with periodontal disease identified an increased risk of renal pathology with increasing severity of periodontitis, and in a large retrospective cohort, the risk of azotaemia was increased almost three-fold in dogs with severe periodontal disease (Pavlica et al 2008;Glickman et al 2011). It is likely that the measures of renal tubular function used in this study are not sensitive enough to detect an effect, and the authors do not argue that this study provides evidence to refute the proposed association.…”

Section: Discussionmentioning

confidence: 99%

“…In a very large cohort of primary practice admissions, found significant associations between severe periodontitis and endocarditis (Glickman et al 2009). In another retrospective cohort study in dogs, the risk of azotaemia increased with increased severity of periodontitis (Glickman et al 2011). Recently, a study of dogs with periodontal disease examined the correlation between several routine clinicopathological variables and the severity of disease (Rawlinson et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Systemic effects of periodontal disease in cats

Cave

Bridges

Thomas

2012

Veterinary Quarterly

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Background: Periodontal disease in cats is a local disease that may have systemic consequences that are affected by treatment. Objective: To test the hypotheses that systemic health indices would be correlated with the severity of periodontitis, and would improve with treatment. Animals and methods: Apparently otherwise healthy cats from an in-bred colony were randomly assigned to a treatment group (n ¼ 30), or a control group (n ¼ 18), which was left untreated for 3 months. Periodontal disease was scored at baseline in the treatment group according to calculus, gingivitis, and alveolar bone loss measured from dental radiographs. Blood, urine and saliva were collected from both groups before, and 16, 45, and 90 days after dental treatment. Assays included haematology, urinalysis, serum biochemistry, serum IgG, salivary IgA, lymphocyte subsets and proliferation, and plasma malonyldialdehyde (MDA). Correlations between the severity of periodontitis and assays at baseline were assessed, and the effect of treatment determined using linear mixed model methodology. Results: The severity of periodontitis was associated with age, bodyweight, total globulins (Globs), Alanine aminotransferase, and IgG, and negatively associated with albumin, haemoglobin, haematocrit, and Aspartate aminotransferase (AST). Treatment significantly reduced IgG, total Globs, AST, and eosinophils, and increased cholesterol. Other leucocyte assays and plasma MDA concentrations were not affected by the treatment. Cats ate dry food faster 1 week after, than they did 1 week before treatment. Conclusions and clinical relevance: Although the clinical significance of these findings are unknown, we conclude that periodontitis is not simply a localized disease, but also impacts on systemic health and wellbeing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic effects of periodontal disease in cats

Cave

Bridges

Thomas

2012

Veterinary Quarterly

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“…Secondly, like all observational studies, our study is subject to possible confounding observations due to unknown or unmeasured factors (premedication, stage of pregnancy, daily water intake and nutrition). Thus, longitudinal studies are needed to determine to what extent periodontal disease is a true risk factor for chronic renal failure and to what extent treatment of periodontal disease affects the kidney function over time [24,25]. Despite these limitations in our study, there is some evidence that warrant considering severe periodontitis as risk factor of chronic renal failure.…”

Section: Referencesmentioning

confidence: 97%

Association of periodontitis and chronic kidney disease in dogs

Nabi¹,

Wani²,

Shah³

et al. 2014

Vet World

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“…A study in 2016 [8] found interconnections between periodontal disease and the pathogenesis of coronary heart disease (CHD), the greatest cause of death in humans worldwide. Moreover, periodontal disease is also related to chronic kidney disease (CKD), as increasing severity of periodontal disease is significantly associated with increasing blood urea nitrogen and serum creatinine concentration [9] .…”

Section: Introductionmentioning

confidence: 99%