Association Between Childhood Anhedonia and Alterations in Large-scale Resting-State Networks and Task-Evoked Activation

Pornpattananangkul, Narun; Leibenluft, Ellen; Pine, Daniel S.; Stringaris, Argyris

doi:10.1001/jamapsychiatry.2019.0020

Cited by 40 publications

(38 citation statements)

References 71 publications

(143 reference statements)

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“…To the Editor We write to report errors in our article, "Association Between Childhood Anhedonia and Alterations in Large-Scale Resting-State Networks and Task-Evoked Activation," published in the June 2019 issue of JAMA Psychiatry. 1 The errors resulted from incorrect postprocessing of previously released resting-state and task-evoked functional magnetic resonance imaging (fMRI) data from the Adolescent Brain Cognitive Development (ABCD) study, and these data had been used in our study.…”

Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

“…1 Data from the ABCD study based on children aged 9 to 10 years from unreferred, community samples during tests of rest (n = 2878; or 2814 without any missing values), reward anticipation (n = 2874), and working memory (n = 2745) were included and analyzed in our study. In our original article, we reported that "phenotype-specific alterations were found in intrinsic large-scale connectivity and task-evoked activation in children with anhedonia" 1 and that "hypoconnectivity at rest and hypoactivation during reward anticipation complementarily map anhedonia onto aberrations in neural-cognitive processes: lack of intrinsic reward-arousal integration during rest and diminishment of extrinsic reward-arousal activity during reward anticipation." 1 On December 2, 2019, the ABCD study made a public announcement indicating incorrect postprocessing of its previously released resting-state and task-evoked fMRI data.…”

Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

“…In our original article, we reported that "phenotype-specific alterations were found in intrinsic large-scale connectivity and task-evoked activation in children with anhedonia" 1 and that "hypoconnectivity at rest and hypoactivation during reward anticipation complementarily map anhedonia onto aberrations in neural-cognitive processes: lack of intrinsic reward-arousal integration during rest and diminishment of extrinsic reward-arousal activity during reward anticipation." 1 On December 2, 2019, the ABCD study made a public announcement indicating incorrect postprocessing of its previously released resting-state and task-evoked fMRI data. 2 Briefly, the ABCD study incorrectly specified field maps of the data obtained on Philips scanners that affected our analysis and involved 359 of 2814 children for the resting-state fMRI, 308 of 2874 children for the task-evoked fMRI during reward anticipation, and 280 of 2745 children for the task-evoked fMRI during working memory.…”

Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

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Notice of Retraction and Replacement. Pornpattananangkul et al. Association between childhood anhedonia and alterations in large-scale resting-state networks and task-evoked activation. JAMA Psychiatry. 2019;76(6):624-633

et al. 2020

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In Reply We welcome the interest in our Original Investigation 1 expressed by ElSayed and Gupta. Regarding the question posed in their title, the answer is yes, the results from our clinical trial show that degarelix holds potential to be a tolerable treatment with significant short-term risk-reduction effects in help-seeking patients with pedophilic disorder, including high-risk patients. The following is an item-by-item response to the other issues raised. (1) We disagree with the assertion that our article equated sexual desire and pedophilic attraction with sexually abusive behavior, and we concur that these are separate issues. (2) The duration of the testosterone suppression in our study is consistent with the existing literature, including the article 2 cited by ElSayed and Gupta. (3) At every visit, the participants reported on their compliance with current medications and on the possible use of anything else outside prescription. We believe the crossing from baseline medications to other medications, reported at baseline in Table 1 of our article 1 (placebo group, n = 3 switch from sertraline to citalopram, initiation of mirtazapine, initiation of risperidone; degarelix group, n = 1 switch from vortioxetine to sertraline) unlikely affected the validity of the results. No patient reported any use of other antiandrogen medications, and we could monitor signs of testosterone supplementation via blood tests. (4) We believe it would be incorrect to claim that the study participants in the degarelix group reported high risk for committing child sexual abuse at the end of the study, as evinced in Table 3 of our article. 1 The fact that the difference is not statistically significant is most likely related to floor effect. (5) ElSayed and Gupta raise an important ethical issue, which is whether evidence-based interventions should be preferred to interventions that seem good but are unsupported by scientific documentation. We believe that interventions should be scientifically scrutinized, and we encourage patients with pedophilic disorder to specifically ask for such interventions. When these are unavailable, most optimally, patients should be offered the possibility to be enrolled in randomized clinical trials to evaluate interventions suggested by their physician. That does not exclude the possibility to combine or replace the supported intervention with other interventions, such as psychotherapy, provided that the patient and physician agree. This is an ethical question that entails pondering potential benefits and risks of the available therapeutic options. (6) The focus of this trial was efficacy of treatment with rapid onset. We agree that a longer trial would have provided useful additional information. However, evaluating the short-term effects is essential to help physicians intervene in the acute phase of the disorder and prevent a chronic course of the disorder. Finally, we want to emphasize that the research on treatment of pedophilic disorder should take a step forward toward embracing the modern pa...

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Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

Section: Notice Of Retraction and Replacement Pornpattananangkul Et mentioning

confidence: 99%

See 1 more Smart Citation

Notice of Retraction and Replacement. Pornpattananangkul et al. Association between childhood anhedonia and alterations in large-scale resting-state networks and task-evoked activation. JAMA Psychiatry. 2019;76(6):624-633

et al. 2020

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“…In some studies, this signal has been accounted for by depression comorbidity (32); in others, this reduction was only observed in adult but not youth samples (33). In a recent study from our group, reduction in striatal activity was observed only in children with anhedonia but not in those with anxiety or ADHD in a community sample (whilst ADHD was associated with BOLD signal aberrations during a working memory task) (29).…”

Section: Specificitymentioning

confidence: 68%

“…First, within depression it remains to be established whether reward processing abnormalities are differentially related to anhedonia as opposed to other symptoms. We only know of two studies, which have found that anhedonia but not low mood are related to reward processing abnormalities in community (not clinically diagnosed) samples (28,29). Yet comparing anhedonia to other plausible symptoms, such as loss of energy or fatigue, is also important.…”

Section: Specificitymentioning

confidence: 99%

Great Expectations: A Critical Review of and Recommendations for the study of Reward Processing as a Cause and Predictor of Depression

Nielson

Keren

O’Callaghan

et al. 2020

Preprint

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Both human and animal studies support the relationship between depression and reward processing abnormalities, giving rise to the expectation that neural signals of these processes may serve as biomarkers or mechanistic treatment targets. Given the great promise of this research line, we scrutinize those findings and the theoretical claims that underlie them. To achieve this, we apply the framework provided by classical work on causality as well as contemporary approaches to prediction. We identify a number of conceptual, practical, and analytical challenges to this line of research, and use a pre-registered meta-analysis to quantify the longitudinal associations between reward processing aberrations and depression. We also investigate the impact of measurement error on reported data. We find that reward processing abnormalities do not reach levels that would be useful for clinical prediction, yet the evidence thus far does not exclude their possible causal role in depression.

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Ensuring the Best Use of Data

2019

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Data sharing is increasingly acknowledged to be a feature of a healthy scientific ecosystem, maximizing the benefits from the often costly business of collecting scientific data and enhancing discovery. Thus, timely data sharing from large research projects is an explicitly stated policy of the National Institutes of Health (NIH). Making data openly and freely available and encouraging researchers to use them for additional analyses ensures the maximum return on the scientific investments that the NIH, and ultimately the US taxpayer, have made.The Adolescent Brain Cognitive Development (ABCD) study is a prime and successful example of the open data-sharing philosophy of the NIH. This ambitious 10-year study of brain development and child health in the United States is in its third year of collecting neuroimaging, genetic, and behavioral information and has completed baseline data collection on 11 878 US children who were recruited at age 9 to 10 years. The study is designed to measure brain development using structural and functional magnetic resonance imaging and to investigate the role of various biological, environmental, and behavioral factors on brain, cognitive, and social/emotional development. 1 Researchers have been encouraged to use this rich, open data set.So far, the scientific community has responded. Two batches of ABCD data have been released, the first in February 2018, which included the children from the first year of recruitment, and the second in April 2019, which included the full baseline sample. Multiple research groups have already published analyses on neurobiological correlates of screen time, 2 neurocognitive associations with problem behaviors, 3 construct validity and psychometric properties of a measure of prodromal psychotic-like symptoms, 4 minority sexual orientation and gender identity, 5,6 eating disorders, 7 and neurobiological associations with anhedonia, 8 and more articles are appearing regularly.The uptake of the initial ABCD data set for such diverse analyses is encouraging. However, to use the data most effectively, it is important to understand the strengths as well as the limitations of the data set. For example, while the study sample and design are well suited for conducting cross-sectional and longitudinal analyses, it would not be appropriate to take the ABCD study cohort as fully representative of the US population for the purposes of calculating population prevalence estimates. 9 Yet, some researchers conducting secondary analyses of ABCD data have done so, which could potentially produce misleading conclusions.A Research Letter by Calzo and Blashill 5 describes the sample as a "US representative cohort." These authors similarly describe the sample as "US representative" in a more recent article. 6 Another Research Letter

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Association Between Childhood Anhedonia and Alterations in Large-scale Resting-State Networks and Task-Evoked Activation

Cited by 40 publications

References 71 publications

Notice of Retraction and Replacement. Pornpattananangkul et al. Association between childhood anhedonia and alterations in large-scale resting-state networks and task-evoked activation. JAMA Psychiatry. 2019;76(6):624-633

Notice of Retraction and Replacement. Pornpattananangkul et al. Association between childhood anhedonia and alterations in large-scale resting-state networks and task-evoked activation. JAMA Psychiatry. 2019;76(6):624-633

Great Expectations: A Critical Review of and Recommendations for the study of Reward Processing as a Cause and Predictor of Depression

Ensuring the Best Use of Data

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