Association between Celiac Disease and Intussusceptions in Children: Two Case Reports and Literature Review

Abstract

Association between celiac disease and intussusception has been reported in adult. Although intussusception is common in children, it rarely has been reported in association with celiac disease. Two children, 5 and 7 years old, with celiac disease are reported here, whose initial presentation was intussusception prior to investigation for concomitant failure to thrive. They presented with acute and severe abdominal distention with vomiting, and donuts and pseudo-kidney appearance in abdominal ultrasonography. One patient's intussusception had reducted spontaneously, however the other had required surgery. In investigation for concomitant failure to thrive, tissue transglutaminase levels were very high and duodenal biopsies revealed celiac disease. Thus celiac testing is recommended in children with intussusception and growth failure.

Intussusception associated with celiac disease in a child: case report and review of literature

“…6,7 For the first time, the association between intussusception and CD was demonstrated by Ruoff M et al, in adult in and by Germann R et al, in children in 1997. 3,4,8 Thereafter, multiple case reports stated association between intussusception and CD in adults, and less frequently in children also. Reported prevalence of intussusception with CD is around 1.6-20% and 1.2-25% in adults and children, respectively, but actual prevalence can be higher because of transient and asymptomatic presentation.…”

Celiac disease in toddler with atypical onset. Case report.

“…A common feature of intussusception in CD is its recurrent character [14][15][16]. The association between acute bowel intussusception and CD has been often described in children [17][18][19]. Instead, intussusception as the presenting symptom of pediatric CD has been rarely reported [20].…”

A Rare Symptom of Celiac Disease: Invagination

“…Bunun sonucunda hipotonik intestinal loplarda normal bağırsak peristaltizminin bozularak invajinasyon oluşumuna neden olabileceği düşünülmektedir (5). Çölyaklı olgularda invajinasyon görülme sıklığının, normal çocuk-lara göre %1,2 daha fazla görüldüğü belirtilmektedir (3,10). Bizim çölyak hastalığı tanısı ile izlediğimiz 236 olgumuzun sadece biri (%0,,4) invajinasyon kliniği ile başvurdu.…”