Association between catatonia and levels of hair and serum trace elements and minerals in autism spectrum disorder

Tinkov, Alexey A.; Skalnaya, Margarita G.; Nv, Simashkova; Klyushnik, T. P.; Skalnaya, Anastasia A.; Bjørklund, Geir; Нотова, С. В.; Kiyaeva, E. V.; Skalny, Anatoly V.

doi:10.1016/j.biopha.2018.10.051

Cited by 38 publications

(15 citation statements)

References 57 publications

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“…Out of ten studies of hair Cr level in the meta-analysis, two studies (Munakata et al, 2006;De Palma et al, 2011) showed higher hair levels of Cr in children with cognitive defects whereas the other studies (Kracke, 1982;Wecker, 1985;Al-Ayadhi, 2005;Blaurock-Busch et al, 2011;Skalny et al, 2016;Alqhazo and Rashaid, 2018;Tinkov et al, 2019) showed lower levels. Alqhazo and Rashaid reported that the Cr level was significantly lower among children who stutter (Alqhazo and Rashaid, 2018).…”

Section: Discussionmentioning

confidence: 95%

“…(Wecker, 1985;Al-Ayadhi, 2005;De Palma et al, 2011;Skalny et al, 2016). Although Tinkov et al reported low Cr levels among children with autism spectrum disorder, this was not a significant difference (Tinkov et al, 2019).…”

Section: Discussionmentioning

confidence: 97%

“…normal (Kracke, 1982) from the hair Cr level. Tinkov et al reported hair and serum Cr levels and Blaurock-Bush reported urine and hair Cr levels (Blaurock-Busch et al, 2011;Tinkov et al, 2019). Results of quality assessment by NOS are shown in Supplementary table 1.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

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Hair, serum and urine chromium levels in children with cognitive defects: A systematic review and meta-analysis of case control studies

et al. 2022

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

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Hair, serum and urine chromium levels in children with cognitive defects: A systematic review and meta-analysis of case control studies

et al. 2022

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“…In a recent literature review of 10 studies comparing hair trace element levels in ASD and controls, four of them found a significant difference in Selenium levels. However, two found a significant increase in Selenium levels in children with ASD, and two found a significant decrease (Tinkov et al, 2019). Another meta-analysis found no significant differences in mean hair or erythrocyte selenium concentrations among 12 studies (Saghazadeh et al, 2017).…”

Section: Selenium (Se)mentioning

confidence: 96%

Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

Behl

Mehta

Pandey

2020

Front. Mol. Neurosci.

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The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.

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“…Another body of research focuses on the effects of Se nutritional intake in children with autism spectrum disorder (ASD). A recent literature review of 4 studies found significant differences in Se tracing in the hair of children with ASD, compared to unaffected children [73]. Two of these 4 studies found increased Se levels in the hair of children with ASD, and the other 2 studies reported the opposite finding.…”

Section: Se Supplementation In a Paediatric Populationmentioning

confidence: 99%

The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge

Filipowicz

Majewska

Kalantarova

et al. 2021

Endokrynologia Polska

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Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. However, Se intake has to be regulated because both Se shortage and overdose negatively impact health. In the case of AIT, Se may alleviate symptoms or prevent progression to hypothyroidism and postpartum hypothyroidism. Se supplementation in euthyroid, subclinical, or overt hypothyroid AIT patients decreased thyroid autoantibodies, lowered or maintained the TSH level, decreased the fT4/fT3 ratio, reduced the body's oxidative stress and inflammatory status, and amended quality of life and thyroid ultrasound structure and volume. In pregnant females, adequate Se intake protected them against miscarriages, preeclampsia/hypertension, preterm birth, small-for-gestational-age infants' birth, and improved child's neuropsychological development. In the elderly population, adequate Se supplementation decreased cardiovascular diseases and hypertension risk, but prolonged intake of excessive doses increased the all-cause mortality rate. Routine Se supplementation implementation requires from researchers and clinicians consideration of specific populational differences in natural Se and iodine supply, the patient's clinical situation (supplementation simultaneously or before levothyroxine treatment, AIT/non-AIT hypothyroidism), individual response to supplementation (Se and selenoprotein P assessment), predisposition (genetic testing), the status of other trace elements, and the interplay between those micronutrients. Moreover, the safety of commercially available Se formulations, doses, and duration of treatment should be determined. Proper guidelines are warranted to standardise the medical approach to Se supplementation. This article presents a comprehensive review of recent randomised-controlled trials, meta-analyses, and clinical trials concerning the risks and benefits of Se supplementation in different clinical settings and specific populations with particular emphasis on AIT in a practical manner. (Endokrynol Pol 2021; 72 (2): 153-162)

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Association between catatonia and levels of hair and serum trace elements and minerals in autism spectrum disorder

Cited by 38 publications

References 57 publications

Hair, serum and urine chromium levels in children with cognitive defects: A systematic review and meta-analysis of case control studies

Hair, serum and urine chromium levels in children with cognitive defects: A systematic review and meta-analysis of case control studies

Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge

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