Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: A 2‐year follow‐up

Pelizza, Lorenzo; Maestri, Davide; Leuci, Emanuela; Quattrone, Emanuela; Azzali, Silvia; Paulillo, Giuseppina; Pellegrini, Pietro

doi:10.1111/eip.13267

Cited by 5 publications

(3 citation statements)

References 41 publications

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“… 51 However, there is some suggestion that these benefits may also be resilient to extinction–a recent observational study which also reproduced specific improvements in negative symptoms with case management, did so over an even longer follow-up period. 52 …”

Section: Discussionmentioning

confidence: 99%

Comparing interventions for early psychosis: a systematic review and component network meta-analysis

Williams,

Ostinelli,

Agorinya

et al. 2024

eClinicalMedicine

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Section: Discussionmentioning

confidence: 99%

Comparing interventions for early psychosis: a systematic review and component network meta-analysis

Williams,

Ostinelli,

Agorinya

et al. 2024

eClinicalMedicine

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“…The GAF is a widely used scale for the assessment of daily functioning in individuals with severe mental illness. The Italian version of the GAF was commonly used also in young Italian people with FEP [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

Short-term disengagement from early intervention service for first-episode psychosis: findings from the “Parma Early Psychosis” program

Pelizza,

Leuci,

Quattrone

et al. 2023

Soc Psychiatry Psychiatr Epidemiol

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Purpose Service disengagement is a major concern for “Early Intervention in Psychosis” (EIP). Indeed, identifying predictors of engagement is crucial to maximize mental healthcare interventions in first-episode psychosis (FEP). No Italian study on this topic has been reported to date. Thus, the aims of this investigation were: (1) to examine short-term disengagement rate in an Italian population of FEP patients treated within an EIP service across a 1-year follow-up period, and (b) to assess the most relevant predictors of disengagement in the first year of treatment. Methods All participants were young FEP help-seeking patients, aged 12–35 years, enrolled within the “Parma Early Psychosis” (Pr-EP) protocol. At baseline, they completed the Positive And Negative Syndrome Scale (PANSS), the Health of the Nation Outcome Scale (HoNOS) and the Global Assessment of Functioning (GAF) scale. Univariate and multivariate Cox regression analyses were used. Results 496 FEP individuals were enrolled in this research. Across the follow-up, a 16.5% prevalence of short-term disengagement was found. Particularly robust predictors of service disengagement were poor baseline treatment non-adherence, living with parents and the presence of brief psychotic disorder or schizophreniform disorder at entry. Conclusion About 16% of FEP patients disengaged the Pr-EP program within the first year of treatment. A solution to reduce disengagement and/or to favor re-engagement of these subjects might be to remain on EIP program caseloads allowing the option for low-intensity support and monitoring, also via remote technology.

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“…The GAF is a widely used scale for measuring daily functioning in patients with psychosis. It has been frequently administered also in young people with FEP [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Rates and predictors of service disengagement in adolescents with first episode psychosis: results from the 2-year follow-up of the Pr-EP program

Pelizza,

Leuci,

Quattrone

et al. 2023

Eur Child Adolesc Psychiatry

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Service disengagement is a major concern for “Early Intervention in Psychosis” (EIP). Indeed, understanding predictors of engagement is important for the effectiveness of mental health interventions, to improve outcome and quality of life, also in adolescents with first episode psychosis (FEP). No specific European investigation on this topic in adolescence has been reported in the literature to date. The aim of this study was to investigate service disengagement rate and predictors in an Italian sample of FEP adolescents treated within an EIP program during a 2-year follow-up period. All participants were adolescents help-seekers (aged 12–18 years) enrolled in the “Parma Early Psychosis” (Pr-EP) program. At baseline, they completed the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF) scale. Univariate and multivariate Cox regression analyses were performed. 71 FEP adolescents were recruited in this research. During the 2 years of our follow-up, a 25.4% prevalence rate of service disengagement was found. Particularly robust predictors of disengagement were lower baseline acceptance of psychosocial interventions, substance abuse at entry, and lower baseline PANSS “Disorganization” factor score. Approximately, 1/4 of our FEP adolescents disengaged from the Pr-EP program during the first 2 years of treatment. A possible solution to decrease disengagement and to favor re-engagement of these young individuals might be to provide the option of low-intensity monitoring and support, also via remote technology.

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Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: A 2‐year follow‐up

Cited by 5 publications

References 41 publications

Comparing interventions for early psychosis: a systematic review and component network meta-analysis

Comparing interventions for early psychosis: a systematic review and component network meta-analysis

Short-term disengagement from early intervention service for first-episode psychosis: findings from the “Parma Early Psychosis” program

Rates and predictors of service disengagement in adolescents with first episode psychosis: results from the 2-year follow-up of the Pr-EP program

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