Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study

Waluyo, Yose; Bukhari, Agussalim; Adnan, Endy; Artika, Sari Rajwani; Yasin, Ahmad; Wahyuni, Insani Nanda; Budu,

doi:10.15562/bmj.v11i3.3395

Cited by 2 publications

(2 citation statements)

References 27 publications

(35 reference statements)

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“…It is in line with a previous study that showed significant improvement in NRS score, WOMAC total score, and all subscale scores of WOMAC after 12 weeks of follow-up dextrose prolotherapy injection. 24,25 This finding is similar to a previous report of significantly greater WOMAC score improvement after 18 weeks follow-up with dextrose prolotherapy injection, and was maintained through 52 weeks. [26][27][28] However, none of the previous studies compared the effectiveness of prolotherapy between mild and moderatesevere knee OA.…”

Section: Discussionsupporting

confidence: 90%

Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study

Waluyo

Artika

Wahyuni

et al. 2023

JKKI

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Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as a gold standard to determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known to be effective in treating pain in knee osteoarthritis, but none has compared the efficacy between mild and moderate-severe knee osteoarthritis. Objective: This study aims to compare the effectiveness of prolotherapy based on its radiological and symptomatic severity in knee osteoarthritis.Methods: In this pre-post study, the participants who underwent dextrose prolotherapy injection (25% intra-articular and 15% periarticular) for three sessions with four weeks intervals were grouped into mild (grade 1-2) and severe (grade 3-4) groups. Participants’ functional status was measured with Western Ontario and McMaster Universities’ arthritis index scores at baseline and week 12.Results: A total of 21 patients (average age 61.42 ± 8.33, BMI 26.81± 3.72) received three therapy sessions. Both groups had significantly better Western Ontario and McMaster Universities arthritis index scores than baseline (-22.57± 11.9; p = 0.002 and -15.42 ± 15.75; p = 0.003). All parameters were improved significantly (p <0.05) in both groups, except the stiffness score (p = 0.292; p = 0.057). There were no differences in functional outcome improvements in both groups (p > 0.05; CI 95%: -21.3 – 7.05).Conclusion: Prolotherapy effectively improves functional outcomes in all stages of knee osteoarthritis.

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Section: Discussionsupporting

confidence: 90%

Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study

Waluyo

Artika

Wahyuni

et al. 2023

JKKI

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“…This information is useful for researchers who want to understand the inflammatory reactions linked to each approach. [12][13][14] Biochemical markers IL-1 levels in the MIA group were significantly higher than in the control group (87.18 ± 15.8 ng/mL, 18.35 ± 6.79 ng/mL, respectively, p < 0.05). IL-1 was observed to be higher in the CFA group compared to the control group (113.75 ± 7.03 ng/mL, p<0.05).…”

Section: Knee-bends Scorementioning

confidence: 90%

A Comparative Study of CFA and MIA Induction Models in Rat Knee Arthritis

Normasari,

Purwanto,

Tinduh

2024

Pharmacogn J.

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This study presents another comparative review of knee joint arthritis induction in rats using two distinct methods: Complete Freund's Adjuvant (CFA) and monosodium iodoacetate (MIA). Different variables are assessed, including bodyweight changes, knee bend scores, and knee diameter measurements, as well as the quantification of interleukin-1β (IL-1β) and C-telopeptide of type II collagen (CTX-II) levels. CFA or MIA induction was used on rats, and 14 days were observed. Our data show that the impact of arthritis induction varies significantly across the two models. Both the CFA and MIA groups showed different changes in terms of bodyweight changes, knee bend scores, and knee diameter variations. Furthermore, the levels of IL-1β and CTX-II, both known indicators of inflammation and cartilage degeneration, were measured. Notably, IL-1β levels in the CFA group were considerably higher than in the MIA-induced rats, although CTX-II concentrations showed a contrary pattern. These findings highlight the need to carefully consider the induction approach when performing arthritis investigations in rats since the model used has a major impact on the reported physiological alterations. This study's comparative analysis provides useful information for researchers looking to use rat knee joint arthritis models, laying the groundwork for a better-informed selection of the best induction strategy depending on desired outcome metrics.

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Association between cartilage biomarker level and functional outcome in knee osteoarthritis patients receiving dextrose prolotherapy: a cross-sectional study

Cited by 2 publications

References 27 publications

Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study

Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study

A Comparative Study of CFA and MIA Induction Models in Rat Knee Arthritis

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