Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study

Blumenfeld, Orit; Williams, Frances; Hart, Deborah; Spector, Tim D.; Arden, N K; Livshits, Gregory

doi:10.1016/j.joca.2013.04.009

Cited by 29 publications

(28 citation statements)

References 46 publications

(43 reference statements)

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“…Twenty two cohort studies which were either population-based (n = 14) [5][6][7][10][11][12][13][14][15][16][17][18][19][20] or hospital-based (n = 8) [21][22][23][24][25][26][27][28] cohorts and three randomized clinical trials [29][30][31] with follow-up time ranged from 1 to 15 years were included. Most of the studies included both genders and only 6 studies evaluated OA in women solely [12,17,19,20,30,31]. Incidence of knee and hip OA was studied in 8 and 6 studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies reported the estimates for different definition of OA. Incidence of OA defined by a radiographic KL scoring system (KL ≥ 2) was used in eight studies [5,7,10,[12][13][14]17,20] among which two studies [7,10] added TJR as grade 5 of KL scoring. In four studies the assessment of OA incidence was based on the measurements of the joint space width [12][13][14]20], while modified Croft scoring was used in one study to defined OA incidence [19].…”

Section: Resultsmentioning

confidence: 99%

“…Incidence of OA defined by a radiographic KL scoring system (KL ≥ 2) was used in eight studies [5,7,10,[12][13][14]17,20] among which two studies [7,10] added TJR as grade 5 of KL scoring. In four studies the assessment of OA incidence was based on the measurements of the joint space width [12][13][14]20], while modified Croft scoring was used in one study to defined OA incidence [19]. Among 22 studies which reported progression of OA, JSN was used to assess OA progression in 10 studies [6,11,14,15,20,21,23,26,30,31].…”

Section: Resultsmentioning

confidence: 99%

“…In the Osteoporotic Fractures study, a multicenter population-based cohort, serum levels of N-terminal telopeptide crosslinks (NTX), a marker of bone turnover, was associated with increased incident risk of hip OA but not with its progression after 8.3 years of follow-up [19]. Contrary, the Chingford Study, another prospective population-based longitudinal cohort, reported no significant association with knee OA incidence for this marker measured in urine [12].…”

Section: Incidence and Progression Of Oa Associated To Biomarkers Of mentioning

confidence: 99%

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Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Incidence and Progression Of Oa Associated To Biomarkers Of mentioning

confidence: 99%

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Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review

et al. 2015

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“…Five studies (three longitudinal studies; two crosssectional studies) reported subgroups of participants with alterations in bone and cartilage metabolism within the knee joint [20,22,32 [34]. Evidence from these papers also suggests this may constitute more than a single phenotype, including some rare variations.…”

Section: Bone and Cartilage Metabolismsmentioning

confidence: 99%

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

et al. 2016

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Background: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. Methods: The aim of this study is to identify the current evidence for the existence of groups of variables which point towards the existence of distinct clinical phenotypes in the KOA population. A systematic literature search in PubMed was conducted. Only original articles were selected if they aimed to identify phenotypes of patients aged 18 years or older with KOA. The methodological quality of the studies was independently assessed by two reviewers and qualitative synthesis of the evidence was performed. Strong evidence for existence of specific phenotypes was considered present if the phenotype was supported by at least two high-quality studies.

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No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

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Palmer

et al. 2019

Journal Orthopaedic Research

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Femoroacetabular impingement (FAI) is a common cause of hip pain and represents a major cause of early osteoarthritis. The role of systemic inflammation in pre‐arthritic hip conditions remains largely unknown and uninvestigated. Serum‐free light chains (sFLCs) are inflammatory markers produced by B cells. This study aimed to determine whether there was evidence of systemic inflammation in patients with FAI, defined by sFLCs, and whether this correlated with markers of disease severity. Participants for this study were recruited from a single center (Nuffield Orthopedic Center, Oxford) and were taking part in the Femoroacetabular Impingement Trial. The cohort comprised 115 individuals (38 male, 77 female, mean age 37 years): 57 individuals received surgical intervention and 58 received physiotherapy. All individuals provided patient‐reported outcome measures and serum samples at baseline and follow‐up 8 months post‐randomization. sFLC concentrations were measured in serum samples by immunoturbidimetry. At baseline, for all individuals, mean polyclonal sFLC concentrations were 30.36 mg/l (standard deviation [SD] 9.23). At follow‐up, the mean polyclonal sFLC concentrations were 31.68 mg/l (SD 9.61) in the surgical intervention cohort, and 29.48 mg/l (SD 7.85) in the physiotherapy intervention cohort. There was no significant correlation between sFLC concentrations and any of the patient reported outcome measures, or radiographic measures: average or maximum alpha angle, or center edge angle. In conclusion, in patients with symptomatic FAI there was no systemic inflammation, as defined by sFLC concentrations, and no correlation between sFLC concentrations and measures of disease severity. The lack of inflammation suggests FAI is a mechanical phenomenon. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2189–2196, 2019

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Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study

Abstract: Aggrecan and COMP circulating levels contribute to identification of phenotype-specific RKOA incidence. These data suggest potentially protective role of aggrecan in cartilage loss, as measured by JSN. High COMP levels are risk factors for development of RKOA, as assessed by K/L scores.

Cited by 29 publications

References 46 publications

Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review

Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement

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