Association between carotid atheroma and cerebral cortex structure at age 73 years

Alhusaini, Saud; Karama, Sherif; Nguyen, Tuong‐Vi; Thiel, Alexander; Bernhardt, Boris C.; Cox, Simon R.; Corley, Janie; Taylor, Adele M.; Evans, Alan C.; Star, John M.; Bastin, Mark E.; Wardlaw, Joanna M.; Deary, Ian J.; Ducharme, Simon

doi:10.1002/ana.25324

Cited by 23 publications

(32 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding supports the assumption that the association between highgrade ICAOD and pathological alterations of cortical microstructure is directly mediated by a restriction of blood flow through the hemodynamically relevant large vessel pathology [16] and not by a widespread distal microvascular pathology. Thus, in contrast to what has been suggested earlier [7,54], ICAOD in this respect might not only be an indicator of generalized atherosclerosis affecting the cortical microstructure by direct involvement of the cerebral microcirculation. Although the macrovascular blood flow velocity as measured with Doppler/ultrasound is related to the regional blood flow of the more distal vasculature, it does not allow assessment of the hemodynamic situation on the tissue level in affected brain parenchyma.…”

Section: Discussioncontrasting

confidence: 70%

“…Cortical thickness reflects the total content of neurons, the cellular composition and the cytoarchitectonic organization of a given cortical region [6] and therefore MRI-based estimation of cortical thickness is frequently used to investigate the integrity of the cerebral cortex on the microstructural level. A previous study demonstrated a significant relationship between unilateral carotid stenosis and widespread bilateral cortical thinning [7]. Other studies found an association between hemodynamic impairment and focal cortical K thinning [8][9][10][11], suggesting a direct detrimental effect of carotid occlusive disease on cortical microstructure; however, a recent study could not replicate this finding and found no influence of carotid stenosis on ipsilateral or contralateral cortical thickness in a multivariate analysis [12].…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease

et al. 2020

View full text Add to dashboard Cite

Purpose To investigate cortical thickness and cortical quantitative T2 values as imaging markers of microstructural tissue damage in patients with unilateral high-grade internal carotid artery occlusive disease (ICAOD). Methods A total of 22 patients with ≥70% stenosis (mean age 64.8 years) and 20 older healthy control subjects (mean age 70.8 years) underwent structural magnetic resonance imaging (MRI) and high-resolution quantitative (q)T2 mapping. Generalized linear mixed models (GLMM) controlling for age and white matter lesion volume were employed to investigate the effect of ICAOD on imaging parameters of cortical microstructural integrity in multivariate analyses. Results There was a significant main effect (p < 0.05) of the group (patients/controls) on both cortical thickness and cortical qT2 values with cortical thinning and increased cortical qT2 in patients compared to controls, irrespective of the hemisphere. The presence of upstream carotid stenosis had a significant main effect on cortical qT2 values (p = 0.01) leading to increased qT2 in the poststenotic hemisphere, which was not found for cortical thickness. The GLMM showed that in general cortical thickness was decreased and cortical qT2 values were increased with increasing age (p < 0.05). Conclusion Unilateral high-grade carotid occlusive disease is associated with widespread cortical thinning and prolongation of cortical qT2, presumably reflecting hypoperfusion-related microstructural cortical damage similar to accelerated aging of the cerebral cortex. Cortical thinning and increase of cortical qT2 seem to reflect different aspects and different pathophysiological states of cortical degeneration. Quantitative T2 mapping might be a sensitive imaging biomarker for early cortical microstructural damage.

show abstract

Section: Discussioncontrasting

confidence: 70%

Section: Introductionmentioning

confidence: 95%

Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Karotis arter hastalıkları ile bilişsel bozuklukların ilişkisini araştıran pek çok çalışma vardır (16,17). Hem semptomatik hem de asemptomatik KAD'nın sağlıklı gönüllülerle karşılaştırıldığında kognitif testlerde kötüleşmeye yol açtığı birçok çalışma ile gösterilmiştir (9,(18)(19)(20)(21).…”

Section: Karotis Arter Darlığı Ve Kognitif Bozukluklarunclassified

The effect of asymptomatic carotid artery stenosis on cognitive functions

Çelik¹,

Aykaç²

2019

TÃ¼rk Beyin Damar Hast Derg

View full text Add to dashboard Cite

Hem serebrovasküler hastalıklar hem demans günlük yaşamı ve zihinsel yetileri bozan önemli klikin durumlardır. Karotis arter darlığı iskemik inmelerin %10-15'inin nedenidir. Hem hafif kognitif bozukluk hem de Alzheimer Hastalığını da dahil olmak üzere tüm demans nedenlerinin etyolojisinde semptomatik ve asemptomatik karotis arter darlığı az bilinen ama önemli bir risk faktörüdür. Bu derlemede asemptomatik karotis darlığının kognisyona olan etkisinin tartışılması amaçlanmaktadır. ABSTRACTBoth cerebrovascular diseases and dementia are important clinical conditions that disrupt daily life and mental abilities. Carotid artery stenosis is the cause of 10-15% of ischemic strokes. Symptomatic and asymptomatic carotid artery stenosis is a little-known, but important risk factor in the etiology of all causes of dementia, including both mild cognitive impairment and Alzheimer's disease. In this review, the effect of asymptomatic carotid artery stenosis on cognition is discussed.

show abstract

“…5 Magnetic resonance imaging (MRI) can noninvasively evaluate brain structural changes and the pathophysiological mechanisms of ACS-related cognitive impairment. 6 Previous studies using structural MRI have identified cortical atrophy in patients with ACS. 6,7 Similarly, the atrophy of subcortical nuclei including the thalamus, caudate, putamen, pallidum, hippocampus, amygdala, and nucleus accumbens was also reported in patients with Alzheimer's disease dementia.…”

Section: Introductionmentioning

confidence: 99%

“…6 Previous studies using structural MRI have identified cortical atrophy in patients with ACS. 6,7 Similarly, the atrophy of subcortical nuclei including the thalamus, caudate, putamen, pallidum, hippocampus, amygdala, and nucleus accumbens was also reported in patients with Alzheimer's disease dementia. Moreover, in ACS patients, reduced cerebral blood flow 8 and decreased vascular reactivity 9 of the basal nuclei (caudate, pallidum and thalamus) were reported.…”

Section: Introductionmentioning

confidence: 99%

<p>Thalamic Atrophy Plays a Crucial Role in the Effect of Asymptomatic Carotid Stenosis on Cognitive Impairment</p>

Zhang

Qing

et al. 2020

CIA

View full text Add to dashboard Cite

Purpose: Our objectives were to assess the abnormalities of subcortical nuclei by combining volume and shape analyses and potential association with cognitive impairment. Patients and Methods: Twenty-nine patients with severe ACS of the unilateral internal carotid artery and 31 controls were enrolled between January 2017 to August 2018. All participants underwent a comprehensive neuropsychological evaluation, blood lipid biochemical measurements, and structural magnetic resonance imaging (MRI) to measure subcortical volumes and sub-regional shape deformations. Basic statistics, correction for multiple comparisons. Seventeen ACS patients underwent carotid endarterectomy (CEA) within one week after baseline measurements, cognitive assessments and MRI scans were repeated 6 months after CEA. Results: The ACS patients had higher apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio and worse performance in all cognitive domains than controls. Moreover, the ACS patients showed more profound thalamic atrophy assessed by shape and volume analysis, especially in the medial dorsal thalamus. No significant differences were found in other subcortical nuclei after multiple comparisons correction. At baseline, thalamic atrophy correlated with cognitive impairment and ApoB/ApoA1 ratio. Furthermore, mediation analysis at baseline showed that the association of carotid intima-media thickness with executive functioning was mediated by thalamic volume. After CEA, cognitive improvement and increase in the bilateral medial dorsal thalamic volume were observed. Conclusion: Our study identified the distinct atrophy of subcortical nuclei and their association with cognition in patients with ACS. Assessments of the thalamus by volumetric and shape analysis may provide an early marker for cerebral ischemia and reperfusion after CEA.

show abstract

Association between carotid atheroma and cerebral cortex structure at age 73 years

Cited by 23 publications

References 37 publications

Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease

Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease

The effect of asymptomatic carotid artery stenosis on cognitive functions

<p>Thalamic Atrophy Plays a Crucial Role in the Effect of Asymptomatic Carotid Stenosis on Cognitive Impairment</p>

Contact Info

Product

Resources

About