Association between Carotid Artery Plaque Type and Cerebral Microbleeds

Saba, Luca; Montisci, Roberto; Raz, Eytan; Sanfilippo, Roberto; Suri, Js; Piga, M.

doi:10.3174/ajnr.a3133

Cited by 17 publications

(13 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The site and features of the atherosclerotic lesions in the carotid artery may differ with regard to their relation to cerebrovascular disease. In a prior study including stroke patients, the characteristics of carotid lesions were relevant regarding the relation of carotid artery atherosclerosis to presence of CMBs: Fatty plaques increased the odds of CMB, but calcified plaques did not . The role of chance or residual confounding is not entirely excluded, and further studies are required to confirm our exploratory observations.…”

Section: Discussionmentioning

confidence: 65%

“…In a prior study including stroke patients, the characteristics of carotid lesions were relevant regarding the relation of carotid artery atherosclerosis to presence of CMBs: Fatty plaques increased the odds of CMB, but calcified plaques did not. 17 The role of chance or residual confounding is not entirely excluded, and further studies are required to confirm our exploratory observations. A limitation of our study is the primarily European ancestry of the Framingham participants, preventing generalization of these results to other ethnic or racial groups.…”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study

Romero

Preis

Beiser

et al. 2016

JAHA

View full text Add to dashboard Cite

BackgroundCarotid atherosclerosis is associated with subclinical ischemic cerebrovascular disease, but its role in hemorrhage‐prone small vessel disease—represented by cerebral microbleed (CMB)—is unclear, although vascular risk factors underlie both conditions. We hypothesized that persons with carotid atherosclerosis would have higher risk of CMB, particularly in deep regions.Methods and ResultsWe studied 1243 participants in the Framingham Offspring Study (aged 56.9±8.8 years; 53% women) with carotid ultrasound available on 2 occasions (1995–1998 and 2005–2008) prior to brain magnetic resonance imaging. Using multivariable logistic regression, we related baseline carotid stenosis, baseline intima–media thickness, and site‐specific carotid intima–media thickness progression (at internal and common carotid locations) to the prevalence and location (lobar or deep plus mixed) of CMB. In addition, we assessed effect modification by lipid levels and use of statin and antithrombotic medications. Carotid stenosis ≥25% (a marker of cerebrovascular atherosclerosis) was associated with presence of CMB overall (Odds Ratio 2.20, 95% CI 1.10–4.40) and at deep and mixed locations (odds ratio 3.60, 95% CI 1.23–10.5). Baseline carotid intima–media thickness was not associated with CMB. Progression of common carotid artery intima–media thickness among persons on hypertension treatment was associated with lower risk of deep and mixed CMB (odds ratio per SD 0.41, 95% CI 0.18–0.96).ConclusionsCumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima–media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 81%

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study

Romero

Preis

Beiser

et al. 2016

JAHA

View full text Add to dashboard Cite

show abstract

“…The type of the plaque is associated not only with the potential (white open arrows) on CT corresponding to the Geroulakos class 3 on US. e, f Calcified plaques (white arrowheads) on CT corresponding to the Geroulakos class 5 on US development of cerebrovascular events but also with the presence of other conditions that affect the brain such as cerebral micro-bleeds and leukoaraiosis [63][64][65].…”

Section: The Plaque Compositionmentioning

confidence: 99%

Imaging of the Carotid Artery Vulnerable Plaque

Saba¹,

Anzidei

Marincola

et al. 2013

Cardiovasc Intervent Radiol

111

View full text Add to dashboard Cite

Atherosclerosis involving the carotid arteries has a high prevalence in the population worldwide. This condition is significant because accidents of the carotid artery plaque are associated with the development of cerebrovascular events. For this reason, carotid atherosclerotic disease needs to be diagnosed and those determinants that are associated to an increased risk of stroke need to be identified. The degree of stenosis typically has been considered the parameter of choice to determine the therapeutical approach, but several recently published investigations have demonstrated that the degree of luminal stenosis is only an indirect indicator of the atherosclerotic process and that direct assessment of the plaque structure and composition may be key to predict the development of future cerebrovascular ischemic events. The concept of ''vulnerable plaque'' was born, referring to those plaque's parameters that concur to the instability of the plaque making it more prone to the rupture and distal embolization. The purpose of this review is to describe the imaging characteristics of ''vulnerable carotid plaques.''

show abstract

“…De fato, pesquisas recentes demonstram que o uso abusivo de EAA em atletas de força pode levar até a morte devido a alterações como: disfunção ventricular 50 , fibrose e morte de miócitos no ventrículo esquerdo 51 , desintegração das fibras musculares cardíacas e perda de discos intercalares e bandas-Z. 52 Em relação às substâncias relatadas pelos usuários de EAA, os estudos demonstram que a Decanoato de Nandrolona 53, 54 corresponde a 76% de utilização pelos adeptos de musculação, seguida pela Testosterona 53, 54 (71%) e Estanozolol 53, 54 (77%) 8 , ainda podendo permutar a ordem de preferência pelos usuários. Isso pode ser decorrente de uma maior acessibilidade, menor custo no comércio, maior divulgação e ou pelas diferenças culturais entre as regiões brasileiras.…”

Section: Prevalência Dos Esteroides Anabólicos Androgênicos No Brasilunclassified

Prevalência do uso e efeitos de recursos ergogênicos por praticantes de musculação nas academias brasileiras: uma revisão sistematizada

Nogueira¹,

Souza²,

Brito³

2013

RBAFS

View full text Add to dashboard Cite

ResumoO objetivo da presente revisão sistemática foi traçar a prevalência, as formas de indicação e os efeitos adversos dos suplementos alimentares (SA) e esteroides anabólicos androgênicos (EAA), cujo uso é relatado por praticantes de musculação nas academias de ginástica do Brasil. Para desenvolvimento deste estudo foi realizada, em novembro de 2011, uma busca nas bases de dados Medline, Scielo, Bireme e Lilacs utilizando as palavras-chave: esteroides anabólicos androgêni-cos, suplementos nutricionais e academias de ginástica. Para ser incluído, o estudo deveria ter investigado o uso de recursos ergogênicos em academias do Brasil. De acordo com os critérios de inclusão, foram selecionadas em um primeiro momento 93 investigações, mas apenas 18 foram incluídas. Os estudos selecionados demonstraram que as regiões Sul e Sudeste são as que possuem maior número de estudos. A maior prevalência de consumo dos SA foi em Belo Horizonte (90,8%), seguido por Vitória (70%), Cascavel (66%) e Curitiba (50,61%), e os produtos mais consumidos foram: proteínas, aminoácidos e creatinas. Para os EAA, a maior prevalência encontrada foi em Belo Horizonte com 85%, seguido por Aracaju (31%) e Rio Grande do Sul (24,9%). Os produtos mais utilizados foram o Decanoato de Nandrolona, a Testosterona e o Estanozolol. Os efeitos colaterais predominantes dos EAA foram surgimento de acne (46 a 94%) e agressividade (47 a 73%). Tanto o consumo de SA quanto o uso dos esteroides anabóli-cos androgênicos encontram-se exacerbados nas academias brasileiras, principalmente, na região Sudeste. Além disso, o uso abusivo dos EAA ocorre devido à falta de informações sobre suas contra indicações, repercutindo em inúmeros efeitos adversos à saúde. Palavras-chaveRecursos ergogênicos; Suplementos alimentares; Esteroides anabólicos androgênicos; Academias de ginástica. Abstract Objective: The objective of the present study was to systematically review the prevalence, indicative ways, and adverse effects of ergogenic resources, such as dietary supplements (DS) and anabolic androgenic steroids (AAS), that were reported, by bodybuilders in gyms in

show abstract

Association between Carotid Artery Plaque Type and Cerebral Microbleeds

Abstract: BACKGROUND AND PURPOSE:CMBs have become increasingly recognized with the widespread use of MR imaging techniques that are sensitive to iron deposits. The purpose of this study was to correlate the presence of CMBs and carotid plaque characteristics.

Cited by 17 publications

References 41 publications

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study

Imaging of the Carotid Artery Vulnerable Plaque

Prevalência do uso e efeitos de recursos ergogênicos por praticantes de musculação nas academias brasileiras: uma revisão sistematizada

Contact Info

Product

Resources

About