Association between Carotid Artery Calcification and Periodontal Disease Progression in Japanese Men and Women: A Cross-Sectional Study

Abstract

Objective: To evaluate the association between alveolar bone loss (ABL) detected on panoramic radiographs and carotid artery calcification (CAC) detected on computed tomography (CT). Methods: The study subjects included 295 patients (mean age ± SD: 64.6 ± 11.8 years) who visited the Matsumoto Dental University Hospital. The rate of ABL and the number of present teeth were measured on panoramic radiographs. Univariate analyses with t-tests and chi-squared tests were performed to evaluate the differences in age, gender, history of diseases, number of present teeth, and the ABL between subjects, with and without CAC. Moreover, multivariate logistic regression analysis, with forward selection and receiver operating characteristic curve (ROC) analysis, was performed. Results: The number of subjects without and with CAC was 174 and 121, respectively. Univariate analyses revealed that CAC was significantly associated with age, hypertension, osteoporosis, number of present teeth, and ABL. Multivariate logistic regression analysis adjusted for covariates revealed that the presence of CAC was significantly associated with ABL (OR = 1.233, 95% CI = 1.167–1.303). In the ROC analysis for predicting the presence of CAC, the the area under the ROC curve was the highest at 0.932 (95% CI = 0.904–0.960) for ABL, which was significant. Conclusions: Our results suggest that the measurement of ABL on panoramic radiographs may be an effective approach to identifying patients with an increased risk of CAC.

Association between Periodontitis and Carotid Artery Calcification: A Systematic Review and Meta-Analysis

“…In addition, the effect of single study on the overall outcomes was assessed by removing a certain study ( Table 1 ). The heterogeneity decreased significantly after the exclusion of Dewake et al [ 39 ] (OR = 3.56, 95%CI = 1.91 − 6.64, I 2 = 86.50%, P < 0.01) or Paju et al [ 40 ] (OR = 5.348, 95%CI = 2.28 − 8.57, I 2 = 86.80%, P < 0.01).…”

Association between Type 2 Diabetes and Classification of Periodontal Disease Severity in Japanese Men and Women: A Cross-Sectional Study

“…The strength of this study is that ABL measured from X-ray images taken during dental treatment associated with type 2 diabetes with a high probability, and therefore patients can be urged to consult the internal medicine department to receive interventions for lifestyle improvement. We previously reported that alveolar bone resorption was effective as a screening factor for carotid artery calcification [32]. We plan to continue investigating further possible associations of ABL with systemic diseases.…”

Association Between Type 2 Diabetes and Classification of Periodontal Disease Severity in Japanese Men and Women: A Cross-Sectional Study

“…The strength of this study is that ABL measured from X-ray images taken during dental treatment associated with type 2 diabetes with a high probability, and therefore patients can be urged to consult the internal medicine department to receive interventions for lifestyle improvement. We previously reported that alveolar bone resorption was effective as a screening factor for carotid artery calcification [26]. We plan to continue investigating further possible associations of ABL with systemic diseases.…”