Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China

Wu, Xiaodong; Hu, Fayun; An, Dongmei; Yan, Bo; Jiang, Xian; Kwan, Patrick; Stefan, Hermann; Zhou, Dong

doi:10.1016/j.yebeh.2010.08.007

Cited by 108 publications

(79 citation statements)

References 23 publications

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“…Our patient had inherited several 'at-risk' HLA alleles for severe drug reactions (Table 2 outlines the drugs and HLA alleles associated with DIHS), [26][27][28][29][30][31][32][33][34][35][36][37]. It is possible that herpes virus reactivation, most notably HHV-6, was the common underlying factor for the multiple drug reactions [38][39][40][41][42], although that was not proven in our case.…”

Section: Discussionmentioning

confidence: 74%

Multiple Drug Induced Hypersensitivity Syndrome Reactions in a Patient with Drugs that Have Known HLA Associations for Reactions

Khan¹,

Bhartia²,

S³

2014

General Med

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We report a rare case of a patient with chronic myeloid leukaemia (CML) who had severe drug hypersensitivity reactions with not only allopurinol and imatinib therapies for the CML, but also to a non-steroidal anti-inflammatory drug and an antibiotic. Each of the drugs (allopurinol and imatinib) when used alone, and in combination, had caused various combinations of fever (hyperpyrexia), rash and/or generalized edema. The patient had the HLA-B*58 haplotype that is associated with allopurinol induced Steven-Johnson syndrome. However, in our case, imatinib alone also caused a similar reaction. We discuss the other 'at-risk' HLA alleles and known drug reactions and that our patient was unfortunate to have all of these HLA alleles. Further studies are required to confirm whether the HLA-B*58 haplotype is a risk factor for imatinib induced adverse cutaneous drug reactions.

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Section: Discussionmentioning

confidence: 74%

Multiple Drug Induced Hypersensitivity Syndrome Reactions in a Patient with Drugs that Have Known HLA Associations for Reactions

Khan¹,

Bhartia²,

S³

2014

General Med

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“…The inclusion criterion for the patient group was the following: subjects who developed AED-induced SJS/ TEN after taking AEDs for less than eight weeks; patients who developed SJS/TEN after simultaneous use of more than one AED were excluded. The definition of SJS/TEN fulfilled Roujeau's diagnostic criteria and is in accordance with our previous studies [12,15]. We also recruited 64 subjects who were tolerant to AED monotherapy (39 tolerant to CBZ, 13 tolerant to LTG, five tolerant to PB, and seven tolerant to PHT), comprising the tolerant group.…”

Section: Methodsmentioning

confidence: 81%

“…Eight CBZ, three LTG, and two PHT subjects were included in our previous reports [12][13][14]. All subjects were of Han Chinese ethnicity.…”

Section: Methodsmentioning

confidence: 99%

Genetic predictors of Stevens–Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population

Wang¹,

Hu²,

et al. 2014

Epilepsy & Behavior

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“…No association of HLA-B * 1502 was found with MPE or HSS in the populations where an association of HLA-B * 1502 with SJS/TEN was observed [14,23,24,25,26,27]. The meta-analysis reinforced the association between HLA-B * 1502 and CBZ-induced SJS/TEN, but not MPE or HSS in Asian populations [28].…”

Section: Pharmacogenomics Study Of Drug-induced Sjs/ten: Association mentioning

confidence: 80%

Clinical Application of Pharmacogenomics: The Example of HLA-Based Drug-Induced Toxicity

Lee

Mahasirimongkol²,

Zhang

et al. 2014

Public Health Genomics

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Pharmacogenomics is gradually becoming more and more indispensable in modern medicine. In several cases, a pharmacogenomics test may alleviate serious drug-induced adverse reactions, if it precedes drug prescription. In this article, we provide an overview of the well-established HLA-based carbamazepine- and allopurinol-induced adverse reactions, as one of the most characteristic examples of the clinical application of pharmacogenomics, highlighting its regional impact in Southeast Asian populations in preventing adverse reactions of certain drug/allele pairs. This example provides useful insights towards evidence generation for policy implementation, including economic evaluation analysis, the implementation of pharmacogenomics testing procedures and monitoring of policy effectiveness, hence serving, per se or in the context of international collaborative efforts, as a model for similar cases in several national healthcare systems worldwide.

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Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China

Cited by 108 publications

References 23 publications

Multiple Drug Induced Hypersensitivity Syndrome Reactions in a Patient with Drugs that Have Known HLA Associations for Reactions

Multiple Drug Induced Hypersensitivity Syndrome Reactions in a Patient with Drugs that Have Known HLA Associations for Reactions

Genetic predictors of Stevens–Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population

Clinical Application of Pharmacogenomics: The Example of HLA-Based Drug-Induced Toxicity

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