Association between caffeine intake and lumbar spine bone mineral density in adults aged 20–49: A cross-sectional study

Wang, Gaoxiang; Fang, Ze-Bin; Liu, Deliang; Chu, Shu-Fang; Li, Hui-Lin; Zhao, Hengxia

doi:10.3389/fendo.2022.1008275

Cited by 14 publications

(12 citation statements)

References 28 publications

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“…As life expectancy has increased, there has been a rise in the prevalence of osteoporosis, leading to a decline in quality of life and an increase in medical expenses. Apart from genetic factors, age, and lifestyle choices [ 3 , 4 ], such as lipid or glucose metabolism [ 5 – 7 ], have recently drawn considerable attention due to their influence on bone metabolism.…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

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Objective Disorders in glucose and lipid metabolism have been shown to exert an influence on bone metabolism. The TyG index, which combines measures of glucose and triglycerides, provides insights into the overall metabolic status. However, the investigation of concurrent disturbances in glucose and lipid metabolism and their specific implications for bone metabolism remains limited in the existing research literature. This study aimed to explore the correlation between the TyG index and bone mineral density (BMD) in US adults. Methods In the National Health and Nutrition Examination Survey (NHANES), subjects were classified based on the TyG index into four groups (< 7.97, 7.97–8.39, 8.39–8.85, > 8.86). Linear regression analysis was conducted to determine the β value and 95% confidence interval (CI). Four multivariable models were constructed. Restricted cubic spline analyses and piecewise linear regression were employed to identify the association between the BMD and TyG index. An analysis of subgroups was also conducted in this study. Results Significant variations in related characteristics were found among the US adult population, who were distributed into four groups based on the quartiles of the TyG index. A negative correlation between the TyG index and lumbar spine BMD was observed. In the multi-adjusted models, compared to Q1 of the TyG index, the β for Q4 of the TyG index for lumbar spine BMD was [β = − 0.008, 95% CI (− 0.017, 0)] in US adults. The association between the TyG index and lumbar spine BMD was found to be nonlinear (all nonlinear p < 0.001), with a threshold value based on restricted cubic spline analyses. Above the threshold point, the β for lumbar spine BMD was − 0.042 (95% CI, − 0.059, − 0.024). Below the threshold points, no significant difference was observed (p > 0.05). No significant interactions were observed among subgroups based on age, gender, presence of diabetes, BMI, and use of antidiabetic and antihyperlipidemic agents. Similar patterns of association were observed in total and subtotal bone density. Conclusions This study identified a nonlinear association between the TyG index and BMD in the US population. Furthermore, an increased level of the TyG index may indicate a higher risk of osteoporosis among US adults. These findings highlight the importance of considering glucose and lipid metabolism disturbances in understanding bone health and the potential for developing preventive strategies for osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

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“…In a clinical study of Korean postmenopausal women (n=4066), using multivariate logistic regression analysis to adjust for confounders, the prevalence of osteoporosis was found to be 36% lower in a cohort with 2-3 times per day coffee intake (n=998) compared with a cohort with less than 1 time per month (n=872) ( 9 ). Besides, the results of another recent cross-sectional study including 7041 U.S. adults (between the ages of 20-49 years) showed that higher coffee intake was significantly and positively associated with LS-BMD (between the ages of 30-39 years) in women ( 34 ). In addition, studies from New Zealand, Hong Kong, and Taiwan have produced similar results ( 6 – 8 ).…”

Section: Discussionmentioning

confidence: 99%

Association of coffee intake with bone mineral density: a Mendelian randomization study

Ye,

Zhong,

Xiong

et al. 2024

Front. Endocrinol.

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BackgroundIn observational studies, the relationship between coffee intake and bone mineral density (BMD) is contradictory. However, residual confounding tends to bias the results of these studies. Therefore, we used a two-sample Mendelian randomization (MR) approach to further investigate the potential causal relationship between the two.MethodsGenetic instrumental variables (IVs) associated with coffee intake were derived from genome-wide association studies (GWAS) of the Food Frequency Questionnaire (FFQ) in 428,860 British individuals and matched using phenotypes in PhenoScanner. Summarized data on BMD were obtained from 537,750 participants, including total body BMD (TB-BMD), TB-BMD in five age brackets ≥60, 45-60, 30-45, 15-30, and 0-15 years, and BMD in four body sites: the lumbar spine, the femoral neck, the heel, and the ultradistal forearm. We used inverse variance weighting (IVW) methods as the primary analytical method for causal inference. In addition, several sensitivity analyses (MR-Egger, Weighted median, MR-PRESSO, Cochran’s Q test, and Leave-one-out test) were used to test the robustness of the results.ResultsAfter Bonferroni correction, Coffee intake has a potential positive correlation with total body BMD (effect estimate [Beta]: 0.198, 95% confidence interval [Cl]: 0.05-0.35, P=0.008). In subgroup analyses, coffee intake was potentially positively associated with TB-BMD (45-60, 30-45 years) (Beta: 0.408, 95% Cl: 0.12-0.69, P=0.005; Beta: 0.486, 95% Cl: 0.12-0.85, P=0.010). In addition, a significant positive correlation with heel BMD was also observed (Beta: 0.173, 95% Cl: 0.08-0.27, P=0.002). The results of the sensitivity analysis were generally consistent.ConclusionThe results of the present study provide genetic evidence for the idea that coffee intake is beneficial for bone density. Further studies are needed to reveal the biological mechanisms and offer solid support for clinical guidelines on osteoporosis prevention.

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“…In addition, Rapuri et al [ 18 ] proved that caffeine could impair osteoblast activation by reducing the vitamin D receptor expression on human osteoblasts and alkaline phosphatase activity. However, clinical research has always drawn inconsistent conclusions with different populations, study designs, or doses of caffeine intake [ 13 , 19 , 20 ]. A recent study of the National Health and Nutrition Examination Survey (NHANES) by Wang et al [ 19 ] indicated caffeine could increase lumbar spine BMD in women aged 30–39 but could have a negative effect on men aged 40–49.…”

Section: Introductionmentioning

confidence: 99%

Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study

Cui

Xiao

et al. 2023

PLoS ONE

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Background Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between caffeine consumption and bone mineral density (BMD) in children and adolescents. Methods Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs). Results In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828). Conclusions Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age.

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Association between caffeine intake and lumbar spine bone mineral density in adults aged 20–49: A cross-sectional study

Cited by 14 publications

References 28 publications

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Association of coffee intake with bone mineral density: a Mendelian randomization study

Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study

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