Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: Interaction with obesity

Teng, Ming‐Sheng; Hsu, Lung‐An; Wu, Semon; Chang, Hsin-Yu; Chou, Hsin-Hua; Ko, Yu‐Lin

doi:10.1016/j.atherosclerosis.2008.10.034

Cited by 40 publications

(40 citation statements)

References 31 publications

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“…This trend was not observed with the rs2794521 SNP. The effects of the SNPs on the variation in CRP levels have been reported in various populations around the world (Kolz et al, 2008;Almeida et al, 2009;Grammer et al, 2009;Schumacher et al, 2009;Teng et al, 2009;Mendoza-Carrera et al, 2010), demonstrating that the effect of CRP SNPs on CRP occurs independent of ethnicity.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, an association among T2D and several CRP SNPs has been reported (Zee et al, 2008), suggesting that they may be candidate genes associated with T2D, a disease that is usually preceded by obesity or metabolic syndrome, disorders related to insulin resistance, and CVD. Meanwhile, Teng et al (2009) reported an obesity-SNP interaction with increased serum levels of CRP and the SNPs rs2794521 and rs1800947 (P = 0.034 and P = 0.020, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have found an association between various haplotypes of the gene and variation in CRP levels (Miller et al, 2005;Kathiresan et al, 2006;Teng et al, 2009). In our study, two haplotypes (TGAG, CGG) had a significant effect on serum CRP levels, a relationship not observed with BMI.…”

Section: Discussionmentioning

confidence: 99%

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Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

et al. 2012

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ABSTRACT.Variants in the C-reactive protein (CRP) gene have been found to be associated with various phenotypic traits. We evaluated the effect of four SNPs in the CRP gene on serum levels of protein and body mass index (BMI) in 150 unrelated Mexican subjects from 18 to 25 years old, without hypertension, non-overweight, and without inflammatory diseases, non-smoking and non-consumers of alcohol. Subjects were measured for BMI, waist circumference, blood pressure, and serum glucose and triglycerides. The identification of SNPs was ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2258-2267 (2012) SNPs in the CRP gene associated with CRP levels and BMI 2259performed by PCR-RFLP. Three of the four SNPs were associated with variation in serum levels of CRP, increased in TT (rs1130864) and GG (rs2794521) genotypes, and decreased in the AA genotype of rs1205.The TT genotype was associated with a significant increase in BMI (β = 1.1 kg/m 2 , P = 0.04). Two haplotypes were significantly associated with increased serum levels of CRP, but not with BMI. We conclude that variation in the CRP gene affects serum protein levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

et al. 2012

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“…This SNP along with other variants have been associated with CRP levels and hypertension in the Turkish study [47], with Ischemic stroke in a Chinese study [48], with arterial pulse-wave velocity in a Japanese cohort [49] and with obesity in a Taiwanese cohort [50]. However, in the Segovia study on a Spanish population, although four SNPs (rs1417938, rs1800947, rs1130864, rs1205) were significantly associated with CRP levels after adjusting for clinical variables and was able to explain up to 2.9% of the total variability in CRP levels, interestingly, this did not include the better known rs3091244 SNP [51].…”

Section: Crp Gene Polymorphismsmentioning

confidence: 99%

“…After adjusting for covariates and post-hoc analysis, only rs3091244 SNP was associated with prevalent CAD, particularly in the non-Hispanic White population [46]. In a more recent analysis of data pooled from 5 different studies comprising of 4610 CAD patients and over CIMT [32] High CRP levels [22,52,53,55] PAD [33] High Systolic Blood pressure [27] Increased arterial stiffness [28] Insulin insensitivity [84] Lipid abnormalities [34] -572G>C rs1800796 CAD / MI [38] High plasma IL6 levels [24] Plasma IL6, CRP, Fibrinogen [54] CRP +1444C>T rs3091244 CAD [46] High plasma CRP levels [42,45,52,85,86] Stroke [87] Hypertension [47] Obesity [50] rs3093058 High Plasma CRP levels [86] rs3091244 High Plasma CRP levels [49] rs1800947 Arterial pulse-wave velocity [49] TNF-α -308G>A rs3091256 CAD [58,60,61,66,67] Obesity [63] Insulin resistance [64] Metabolic syndrome [62] Plasma CRP levels [65] CAD -Coronary Artery Disease, CIMT -Carotid Intima Media Thickness, CRP-C-reactive protein, IL 6 -Interleukin 6, MI-Myocardial Infarction, PAD -Peripheral Arterial Disease, SNP -Single Nucleotide Polymorphism, TNF-α -Tumor necrosis factor-alpha. Note: References given in brackets.…”

Section: Crp Gene Polymorphismsmentioning

confidence: 99%

Implications of Genetic Polymorphisms in Inflammation-Induced Atherosclerosis

Shanker

Kakkar²

2010

TOCMJ

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Abstract:Inflammation is the mainstay of atherosclerosis and is an important governing factor at all stages of the disease process from lesion formation to plaque build-up and final end-stage rupture and thrombosis. An overview of the numerous clinico-epidemiological studies on the association between inflammatory gene polymorphisms and Cardiovascular disease (CVD) and its co-morbidities have shown that the risk associated with any single genotype is modest while the haplotypes, especially those defined on the basis of tag-SNP approach, have better coverage of the gene and show moderately higher impact on disease risk. Nevertheless, even these associations have been inconsistent with low cross-race repeatability. This has been attributed to many plausible causes such as clinical heterogeneity, sample selection criteria, variable genetic landscapes across different ethnic groups, confounding effect of co-morbidities etc. On the other hand, unbiased studies such as the family-based linkage and case-control based associations that have taken into account, thousands of genotypic markers spanning the whole genome, have had the ability to identify novel genetic loci for coronary artery disease. These studies have shown that many inflammatory genes are involved in the regulation of specific biomarkers of inflammation that collectively contribute to the disease-associated risk. In addition, there appears to be considerable cross talk between the different biochemical and metabolic processes. Therefore, consideration of all these factors can build towards an 'atherosclerotic bionetwork' that can refine our quest for developing a robust risk stratification tool for cardiovascular disease.

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Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C‐reactive protein in white British population

Ploner

Wang

et al. 2023

Molec Gen & Gen Med

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BackgroundC‐reactive protein (CRP) is a sensitive biomarker of inflammation with moderate heritability. The role of rare functional genetic variants in relation to serum CRP is understudied. We aimed to examine gene mutation burden of protein‐altering (PA) and loss‐of‐function (LOF) variants in association with serum CRP, and to further explore the clinical relevance.MethodsWe included 161,430 unrelated participants of European ancestry from the UK Biobank. Of the rare (minor allele frequency <0.1%) and functional variants, 1,776,249 PA and 266,226 LOF variants were identified. Gene‐based burden tests, linear regressions, and logistic regressions were performed to identify the candidate mutations at the gene and variant levels, to estimate the potential interaction effect between the identified PA mutation and obesity, and to evaluate the relative risk of 16 CRP‐associated diseases.ResultsAt the gene level, PA mutation burdens of the CRP (β = −0.685, p = 2.87e‐28) and G6PC genes (β = 0.203, p = 1.50e‐06) were associated with reduced and increased serum CRP concentration, respectively. At the variant level, seven PA alleles in the CRP gene decreased serum CRP, of which the per‐allele effects were approximately three to seven times greater than that of a common variant in the same locus. The effects of obesity and central obesity on serum CRP concentration were smaller among the PA mutation carriers in the CRP (pinteraction = 0.008) and G6PC gene (pinteraction = 0.034) compared to the corresponding non‐carriers.ConclusionPA mutation burdens in the CRP and G6PC genes are strongly associated with decreased serum CRP concentrations. As serum CRP and obesity are important predictors of cardiovascular risks in clinics, our observations suggest taking rare genetic factors into consideration might improve the delivery of precision medicine.

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Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: Interaction with obesity

Cited by 40 publications

References 31 publications

Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

Implications of Genetic Polymorphisms in Inflammation-Induced Atherosclerosis

Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C‐reactive protein in white British population

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