Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

Köhler‐Forsberg, Ole; Buttenschøn, Henriette Nørmølle; Tansey, Katherine E.; Maier, Wolfgang; Hauser, Joanna; Dernovšek, Mojca Zvezdana; Henigsberg, Neven; Souery, Daniel; Farmer, Anne; Rietschel, Marcella; McGuffin, Peter; Aitchison, Katherine J.; Uher, Rudolf; Mors, Ole

doi:10.1016/j.bbi.2017.02.020

Cited by 226 publications

(167 citation statements)

References 36 publications

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“…Some recently conducted meta‐analyses have shown that some cytokines, such as IL‐6, TNF‐α, and IL‐10, appear to be increased in individuals with MDD and BD when compared to healthy controls . The contribution of sex differences in immune responses to the pathophysiology of MDD is still unclear, suggesting that women show higher immunological changes than men . Our findings suggest that neuroinflammation, measured in this study through IL‐6 and TNF‐α in women, is not associated with diagnostic conversion to BD.…”

Section: Discussionmentioning

confidence: 46%

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Moreira

Cardoso

Mondin

et al. 2019

Psychiatry Clin Neurosci

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Aim The aim of this study was to identify biomarkers associated with major depressive disorder (MDD) and conversion from MDD to bipolar disorder (BD) in an outpatient sample of women. Methods This was a longitudinal study including women diagnosed with MDD and aged 18 to 60 years. The follow‐up was 3 years. The diagnosis was performed using the Mini International Neuropsychiatric Interview Plus. Blood collection was just performed in the first phase. Serum interleukin‐6, tumor necrosis factor‐α, brain‐derived neurotrophic factor, glial cell‐derived neurotrophic factor, and nerve growth factor (NGF) levels were measured using a commercial immunoassay kit. Results We included 156 women. The conversion rate from MDD to BD was 15.4% (n = 24). NGF serum levels were increased in patients who converted to BD compared to the remitted MDD group and current MDD group (P = 0.013). The Bonferroni post‐hoc test for multiple comparisons revealed significant differences for higher NGF levels in patients who converted to BD compared to patients with current MDD (P = 0.037). Interleukin‐6, tumor necrosis factor‐α, brain‐derived neurotrophic factor, and glial cell‐derived neurotrophic factor serum levels did not differ among the groups. Conclusion Our results suggest that NGF might be a useful biomarker associated with early detection of conversion to BD, helping clinicians in the clinical diagnosis.

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Section: Discussionmentioning

confidence: 46%

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Moreira

Cardoso

Mondin

et al. 2019

Psychiatry Clin Neurosci

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“…In this study, high serum hs-CRP levels were associated with poor overall quality of life and mobility problems. This can be explained by the sickness behavior model of sickness syndrome theory [16, 37]. Inflammation can cause symptoms by directly affecting the central nervous system, and CRP is a common marker of such inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated serum CRP levels have been associated with obesity and systemic inflammation in MetS [4]. Additionally, the association between inflammation, as indicated by serum CRP levels, and psychiatric disorders has been studied [16, 24, 28, 29], and some studies using serum CRP have shown that chronic inflammation may exert a significant negative impact on quality of life [21, 22]. …”

Section: Introductionmentioning

confidence: 99%

Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome

Kim

Song

2018

Diabetol Metab Syndr

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BackgroundMetabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relationships among inflammation, mental health, quality of life, and other diseases have been conducted.MethodsWe investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels, as an indicator of inflammation, and the quality of life and psychiatric symptoms of Korean adults with MetS. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians conducted from January to December 2015. Data from 1600 participants were analyzed in this study. Quality of life was assessed using the EuroQol 5-dimension (EQ-5D) instrument.ResultsSerum hs-CRP levels showed a significant inverse correlation with the EQ-5D index of the overall quality of life. High serum hs-CRP levels were positively associated with mobility problems and suicidal ideation in adults with MetS (multivariate-adjusted odds ratio [OR] 1.66, 95% confidence interval [CI] 1.03–2.66, p = 0.036; and multivariate-adjusted OR 2.48, 95% CI 1.23–4.99, p = 0.011).ConclusionsThese findings suggest that the elevated inflammatory status in MetS is associated with decreased quality of life and mental health problems. Further prospective studies are needed to confirm the impact of inflammation on the quality of life and mental health of adults with MetS.

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“…Women are more affectively sensitive to the effects of inflammatory challenge than men, 6 and a recent study demonstrated an association of CRP concentrations with depression severity and specific depressive symptoms in women only. 26 …”

Section: Introductionmentioning

confidence: 99%

Inflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression

Kruse¹,

Congdon²,

Olmstead³

et al. 2018

J. Clin. Psychiatry

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Objective Electroconvulsive therapy (ECT) is the most robust acute treatment for severe major depressive disorder, yet clinical response is variable. Inflammation is associated with depression, especially in women, and levels of C-reactive protein (CRP) and interleukin-6 (IL-6) predict response to antidepressant medications. This study evaluated whether markers of inflammation predicted response to electroconvulsive therapy (ECT) in patients with treatment resistant depression, and to what extent this association differed between men and women. Methods In patients (n=29) with a current major depressive episode diagnosed using DSM-IV-TR criteria, undergoing ECT at an academic referral center, levels of CRP, IL-6, IL-8, tumor necrosis factor (TNF)-α, and severity of depressive symptoms (Montgomery-Asberg Depression Rating Scale, MADRS) were prospectively evaluated before ECT treatment, after the second ECT session, and again at the completion of the index treatment series. Data were collected between 12/2011 and 12/2014. The primary outcome was end-of-treatment MADRS score. Results In multivariate analyses, higher levels of IL-6 at baseline, but not other inflammatory markers or clinical variables, were associated with lower end-of-treatment MADRS score (p=0.01). When stratified by sex, IL-6 remained a significant predictor of end-of-treatment MADRS for women (p=0.02) but not men (p=0.1), and CRP emerged as a significant predictor for women (p=0.04) but not men (p=0.66). CRP and IL-6 increased from baseline to the second ECT session (p’s<0.01) and returned to baseline levels at end of treatment; these changes did not relate to MADRS score over the course of ECT. Conclusions Levels of IL-6 prior to ECT treatment may be useful in identifying those depressed patients most likely to benefit from ECT treatment. In contrast, acute changes in IL-6 and CRP may reflect spikes in inflammatory response related to the initiation of seizure therapy, but not mood. Assessment of pre-treatment inflammatory biomarkers, especially in women, might be useful in guiding treatment decision-making in treatment resistant depression.

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Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

Cited by 226 publications

References 36 publications

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome

Inflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression

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