Association between C-reactive protein, carotid intima-media thickness and P-wave dispersion in obese premenopausal women: an observational study

Özuğuz, Ufuk; Ergün, Gökhan; Işık, Serhat; Gökay, Ferhat; Tütüncü, Yasemin; Akbaba, Gülhan; Berker, Dilek; Güler, Serdar

doi:10.5152/akd.2012.008

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…CIMT is an indicator of atherosclerosis, and studies have shown that it is an indicator of cardiovascular events and mortality (9–12). It has also been found to be associated with CAD, coronary atherosclerotic load, endothelial dysfunction, and mitral annular calcification, which has a value in the prediction of atherosclerosis and arrhythmias (13–19). …”

Section: Introductionmentioning

confidence: 99%

Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients

Köseoğlu¹,

Kurmuş²,

Ertem³

et al. 2015

Anatol J Cardiol

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Objective:Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disease (CVD). Carotid intima-media thickness (CIMT) is the sign of subclinical atherosclerosis. Therefore, the aim of this study was to evaluate whether CIMT measurement is related with significant coronary artery disease (CAD) in patients with COPD, similar to those without COPD.Methods:One hundred and eight patients with previously diagnosed COPD and 78 patients without COPD who underwent coronary angiography (CAG) were enrolled in this prospective cross-sectional study. Carotid artery ultrasonography was performed on all patients after coronary angiography by another operator who was blind to the CAG results. The patients were divided into four subgroups as follows: group 1: COPD (-) and CAD (-); group 2: COPD (-) and CAD (+); group 3: COPD (+) and CAD (+); and group 4: COPD (+) and CAD (-). Patients with previous coronary revascularization, carotid artery disease, and lung disease other than COPD were not enrolled in this study. The student’s t-test, chi-square analysis, multiple logistic regression analysis, and receiver operating characteristic (ROC) curve were used for statistical analysis.Results:CIMT was found to be highest in patients with both significant CAD and COPD (group 3) (p<0.05). Among the 108 COPD patients, the odds ratio associated with the CIMT >1.25 mm to predict CAD was 12.4. The area under the ROC curve for a cut-off value of 1.25 mm for CIMT to predict CAD in COPD patients was calculated as 0.913, with a sensitivity of 89.7% and specificity of 86.7%.Conclusion:CIMT has a predictive value for the presence of CAD in patients with COPD. Further studies are needed to validate our results. (Anatol J Cardiol 2016; 16: 601-7)

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Section: Introductionmentioning

confidence: 99%

Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients

Köseoğlu¹,

Kurmuş²,

Ertem³

et al. 2015

Anatol J Cardiol

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“…It has been reported that interatrial conduction delays are associated with initiating and maintaining atrial fibrillation [35,36]. Furthermore, some authors reported increased PWD is associated with stable coronary artery disease, carotid atherosclerosis, and slow coronary phenomenon [9,37,38]. This suggests that another pathophysiological mechanism for increased PWD is endothelial dysfunction as well as autonomic imbalance.…”

Section: Discussionmentioning

confidence: 99%

P wave dispersion in patients with erectile dysfunction

Öncel

Akkoç

2019

Interventional Medicine and Applied Science

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Background and aims P wave dispersion (PWD) has been reported to be a non-invasive electrocardiographic predictor for atrial fibrillation. The aim of this study is to evaluate PWD between men with erectile dysfunction (ED) and healthy controls in order to investigate whether PWD was prolonged in patients with ED and related to severity of the disease. Methods This study included a total of 72 men (42 patients with ED and 30 healthy controls). Demographic data and clinical features were recorded on admission. An electrocardiographic evaluation was obtained to measure PWD values for both patients and controls. Results Maximum P wave duration was 108.5 ± 4.7 and 108.3 ± 4.3 in ED group and control group, respectively (p = 0.748). Minumum P wave duration was significantly higher in the control group than in the ED group. PWD was 48.1 ± 5.9 in the ED group. As a result, PWD was prolonged in patients with ED (48.1 ± 5.9 vs. 38.0 ± 3.9, p < 0.05). A significant negative correlation was observed between IIEF score and PWD values (p < 0.05, r = −0.662). Conclusions Patients with ED exhibited prolonged PWD values compared with normal controls. In addition, PWD was found to be associated with severity of the disease.

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“…PD has also been found to be associated with carotid atherosclerosis [8]. In addition, it has been shown that P-wave dispersion is increased in coronary slow- flow phenomenon [25].…”

Section: Discussionmentioning

confidence: 99%

“…A growing evidence shows that people who are higher PD have higher risks for several cardiovascular-related conditions such as diabetes mellitus, obesity, hypertension, peripheral vascular disease, and myocardial infarction [4-7]. Furthermore, PD has been found to be to associated with an increase in carotid intima-media thickness and inflammatory markers such as C-reactive protein [8]. However, there are very few studies that have shown the relationship between stable coronary artery disease and P wave dispersion [9].…”

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confidence: 99%

P-wave dispersion and its relationship with the severity of the disease in patients with stable coronary artery disease

Akın

Fıratlı

Katkat

et al. 2014

North Clin Istanbul

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OBJECTIVE:P- wave dispersion (PD) is an indicator of inhomogeneous and discontinuous propagation of sinus impulses. In the present study we aimed to investigate the PD and its association with the severity of the disease. in patients with stable coronary artery disease.METHODS:We prospectively analyzed 60 subjects with coronary artery disease (CAD) and 25 subjects with nor-mal coronary angiograms (control group). The maximum and minimum P-wave duration and PD were measured from the 12-lead surface electrocardiograms. The CAD severity was assessed by the severity score (Gensini score) and the number of vessels involved (vessel score).RESULTS:P max was longer in CAD group compared with the control group (p<0.001). PD was greater in the CAD group, compared with the control group (p<0.001). However, P min did not differ between the two groups. In bi-variate correlation, increased PD was correlated with presence of diabetes mellitus (r=0.316, p=0.014), smoking (r=0.348, p=0.006), left ventricular ejection fraction (r=-0.372, p=0.003), vessel score (r=0.848, p=0.001), and Gensini score (r=0.825, p=0.001). Multiple linear regression analysis showed that PD was independently associ¬ated with vessel score ((3=0.139, p=0.002) and Gensini score ((3=0.132, p=0.007).CONCLUSION:PD was greater in patients with CAD than in controls and it was associated with CAD severity.

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Association between C-reactive protein, carotid intima-media thickness and P-wave dispersion in obese premenopausal women: an observational study

Cited by 8 publications

References 36 publications

Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients

Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients

P wave dispersion in patients with erectile dysfunction

P-wave dispersion and its relationship with the severity of the disease in patients with stable coronary artery disease

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