Association Between Breast Arterial Calcification on Mammography and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Regner, Sean; Osman, Khansa; Shahan, Cimmie; Kheiri, Babikir; Kadiyala, Madhavi; Sokos, George; Sengupta, Partho P.; Shapiro, Michael D.; Michos, Erin D.; Bianco, Christopher

doi:10.1089/jwh.2020.8733

Cited by 13 publications

(4 citation statements)

References 34 publications

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“…Arterial wall calcification can occur anywhere in the body. Not surprisingly, breast arterial calcifications are associated with a higher risk for stroke and heart attack [169][170][171] (Figure 1).…”

Section: Microvascular Dysfunctionmentioning

confidence: 99%

Energy Dynamics in Chronic Heart Failure, Chronic Kidney Disease & the Cardiorenal Syndrome: A New Causal Paradigm

Thorp¹,

Thorp²,

Northrup³

et al. 2023

G Med Sci

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In this paper we examine HF and CKD through the lens of a new causal paradigm: as a conjoined energy deficiency syndrome whose progression is governed by impaired energy generation by the cardiovascular system leading to subsequent deterioration of blood energy dynamics. Due to the immense complexity of this topic our intention is not to go into unnecessary and laborious detail on specific cellular and molecular aspects of the syndromes but, instead, to use illustrative examples to establish overarching principles and to highlight the connection between the deteriorating energy field and all resultant aberrations. Indeed, once the energy dynamics are recognized cellular and molecular descriptions become superfluous. Our use of the term 'causal' is meant to imply that future breakthroughs in the treatment (and potential reversal) of these complex disease states necessarily entails recognition and correction of underlying energy deficits.

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Section: Microvascular Dysfunctionmentioning

confidence: 99%

Energy Dynamics in Chronic Heart Failure, Chronic Kidney Disease & the Cardiorenal Syndrome: A New Causal Paradigm

Thorp¹,

Thorp²,

Northrup³

et al. 2023

G Med Sci

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“…Вместе с тем, каждая третья умершая от ССЗ женщина не имеет обструктивного поражения коронарных артерий (стеноза ≥50%) по данным коронарографии [3]. В связи с этим важной практической задачей является поиск новых гендерспецифических маркеров, позволяющих улучшить стратификацию сердечно-сосудистого риска у женщин, среди которых одним из наиболее перспективных является кальциноз артерий молочной железы (КАМЖ), легко выявляемый при маммографии и ассоциирующийся с более высокой сердечно-сосудистой заболеваемостью и смерт ностью [4][5][6]. При маммографии наряду со структурными изменениями ткани молочной железы, в 10-15% случаев встречается КАМЖ [7], который с онкологической точки зрения расценивается как "доброкачественная находка", но одновременно с этим может указывать на высокую вероятность неблагоприятных сердечно-сосудистых событий.…”

Section: Introductionunclassified

Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Bochkareva,

Butina,

Bayramkulova

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the relationship between breast arterial calcification (BAC) and the presence and severity of carotid atherosclerosis.Material and methods. We analyzed 4274 digital mammograms of women who underwent diagnostic mammography. In addition to the standard diagnosis of breast diseases, BAC was assessed in all mammograms. The study included 198 women aged 40-74 years, who made up 2 groups with and without BAC, each consisting of 99 people, formed on a case-control basis. The severity of BAC was assessed by a 12-point score. Duplex ultrasound of extracranial arteries determined plaque presence, the severity of CA stenosis (in percent) and intima-media thickness (IMT). All women underwent physical and laboratory examinations, electrocardiography, and were interviewed using a questionnaire assessing socio-demographic data, menopausal status, risk factors, and diseases.Results. The groups did not differ in lipid levels, blood glucose, body mass index, incidence of hypertension, diabetes, or smoking. Women with BAC had a higher incidence of menopause (94,9% vs 84,8%, p=0,033), coronary artery disease (13,1% vs 4,2%, p=0,039) and osteoporosis (18,2% vs 6,1%, p=0,016) in history. In women with BAC, at least one carotid plaque was observed significantly more often than in those without BAC — in 79,8% and 60,6% of cases, respectively (p=0,005). Women with BAC compared with women without BAC had a greater plaque number (1,0 [1,0; 3,0] vs, 1,0 [1,0; 2,0], p<0,001) and a more severe carotid stenosis, assessed by maximum (25,0 [17,5; 35,0] vs 20,0 [0,0; 27,5], p=0,001), total (30,0 [20,0; 92,5] vs 25,0 [0,0; 50,0], p<0,001) and mean arterial stenosis (25,0 [17,5; 30,0] vs 20,0 [0,0; 25,0], p=0,001). For the first time, a positive relationship was revealed between the severity of carotid atherosclerosis and BAC as follows: women with greater severity of maximum and total carotid stenosis had more severe BAC (p=0,018 and p=0,003, respectively). There was no association between BAC and IMT (p=0,115).Conclusion. BAC is associated with a higher incidence and severity of carotid atheromatosis. A positive relationship was found between the severity of BAC and carotid stenosis. The data obtained confirm the prospects of mammography as a screening technique for identifying individuals with an increased cardiovascular risk.

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“…Calcification can also arise from fibroadenoma in the interstitial tissues and from arteriosclerotic changes in the arterial walls. A recent study indicated that mammography can be used to detect arterial wall calcification, which may have potential implications in the risk assessment of cardiovascular events [8]. Calcification detected by mammography can arise from various causes; therefore, interpreting the cause of calcification becomes a crucial factor for diagnosis.…”

mentioning

confidence: 99%

Arterial Calcification Disappearance in Breast Imaging: A Key Indicator for Transition to Invasive Ductal Carcinoma

Sato,

Fujioka,

Onishi

et al. 2024

Diagnostics

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A woman in her 70s, initially suspected of having fibroadenoma due to a well-defined mass in her breast, underwent regular mammography and ultrasound screenings. Over several years, no appreciable alterations in the mass were observed, maintaining the fibroadenoma diagnosis. However, in the fourth year, an ultrasound indicated slight enlargement and peripheral irregularities in the mass, even though the mammography images at that time showed no alterations. Interestingly, mammography images over time showed the gradual disappearance of previously observed arterial calcification around the mass. Pathological examination eventually identified the mass as invasive ductal carcinoma. Although the patient had breast tissue arterial calcification typical of atherosclerosis, none was present around the tumor-associated arteries. This case highlights the importance of monitoring arterial calcification changes in mammography, suggesting that they are crucial indicators in breast cancer diagnosis, beyond observing size and shape alterations.

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Association Between Breast Arterial Calcification on Mammography and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 34 publications

Energy Dynamics in Chronic Heart Failure, Chronic Kidney Disease & the Cardiorenal Syndrome: A New Causal Paradigm

Energy Dynamics in Chronic Heart Failure, Chronic Kidney Disease & the Cardiorenal Syndrome: A New Causal Paradigm

Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Arterial Calcification Disappearance in Breast Imaging: A Key Indicator for Transition to Invasive Ductal Carcinoma

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