Association between bone turnover markers and periodontitis: A population‐based cross‐sectional study

Abstract

Aim To examine the associations between bone turnover markers and periodontitis in two cross‐sectional population‐based studies. Materials and Methods We used data from two independent adult samples (N = 4993), collected within the Study of Health in Pomerania project, to analyse cross‐sectional associations of N‐procollagen type 1 amino‐terminal propeptide (P1NP), C‐terminal cross‐linking telopeptide, osteocalcin, bone‐specific alkaline phosphatase (BAP), fibroblast growth factor 23, wingless‐type mouse mammary tumour virus integration site family member 5a (WNT5A), and sclerostin values with periodontitis. Confounder‐adjusted gamma and fractional response regression models were applied. Results Positive associations were found for P1NP with mean pocket probing depth (PPD; eβ=1.008; 95% confidence interval [CI]: 1.001–1.015), mean clinical attachment loss (mean CAL; eβ=1.027; 95% CI: 1.011–1.044), and proportion of sites with bleeding on probing (%BOP; eβ=1.055; 95% CI: 1.005–1.109). Similar associations were seen for BAP with %BOP (eβ=1.121; 95% CI: 1.042–1.205), proportion of sites with PPD ≥4 mm (%PPD4) (eβ=1.080; 95% CI: 1.005–1.161), and sclerostin with %BOP (eβ=1.308; 95% CI: 1.005–1.704). WNT5A was inversely associated with mean PPD (eβ=0.956; 95% CI: 0.920–0.993) and %PPD4 (eβ=0.794; 95% CI: 0.642–0.982). Conclusions This study revealed scattered associations of P1NP, BAP, WNT5A, and sclerostin with periodontitis, but the results are contradictory in the overall context. Associations reported in previous studies could not be confirmed.

Optimizing a Diagnostic Model of Periodontitis by Using Targeted Proteomics

“…Although the use of an affinity-based proteomic assay to improve PD classification is novel in dentistry, previous reports have studied adjunctive biomarkers. Body fluids like saliva, gingival crevicular fluid (GCF), and blood have long been investigated for their diagnostic value, and several promising leads were found, such as peptidases, cytokines, and bone turnover markers. − Yet, no solitary biomarker prevailed in clinical practice . Multifactorial diseases like PD are characterized by an interplay of diverse metabolic pathways, and single markers may not reflect this intricacy .…”

Gingival crevicular fluid periodontal ligament‐associated protein‐1, sclerostin, and tumor necrosis factor‐alpha levels in periodontitis

“…1,2 To date, many studies have investigated the levels of bone biomarkers which are associated with bone formation and resorption in periodontal tissues, serum, and oral biofluids of patients with periodontitis. 3,4 Currently, periodontal disease is diagnosed primarily by clinical measurements such as probing depth (PD), clinical attachment loss (AL), bleeding on probing (BOP) recordings, and radiographical findings which are only able to reflect the periodontal destruction background rather than current disease activity, future progression, and therapy response. 3,5 Therefore, new diagnostic methods are required to identify the probable risk factors for the early detection of incipient periodontitis.…”

“…In other words, periodontal bone loss can be considered an unfavorable combination of enhanced bone resorption and diminished bone formation 1,2 . To date, many studies have investigated the levels of bone biomarkers which are associated with bone formation and resorption in periodontal tissues, serum, and oral biofluids of patients with periodontitis 3,4 …”

Oral health, periodontal phenotype in patients with different mineral density (morphotypes) of bone tissue

“…Проведені дослідження свідчать про посилення процесів резорбції у хворих із загостреним перебігом ГП [3]. Іншими дослідженнями не встановлено кореляційних взаємозв'язків між маркерами резорбції кісткової тканини й пародонтитом [9], а в деяких дослідженнях піддається сумніву клінічне значення цих маркерів для прогнозування та моніторингу пародонтиту [10]. Маркери кісткоутворення мають слабку кореляцію з клінічними проявами пародонтиту, а саме глибиною пародонтальних карманів та клінічним прикріпленням ясен [8].…”