Association between bone turnover markers, clinical variables, spinal syndesmophytes and bone mineral density in Mexican patients with ankylosing spondylitis

Gámez-Nava, JI; Cerda-Trujillo, LF De la; Vazquez-Villegas, Maria Luisa; Cons-Molina, Fidencio; Alcaraz-Lopez, MF; Muñiz, Soraya Amalí Zavaleta; Rocha-Muñoz, AD; Martinez-Garcia, EA; Corona-Sanchez, E. G.; Salazar-Páramo, Mario; Fajardo-Robledo, Nicte Selene; Olivas-Flores, Eva Maria; Cardona-Muñoz, Ernesto Germán; González-López, Laura

doi:10.3109/03009742.2016.1152399

Cited by 20 publications

(13 citation statements)

References 14 publications

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“…Bone turnover markers (BTM) may also reflect the processes leading to excessive bone formation in axSpA: serum C-terminal telopeptide fragments of type I collagen (sCTX), a bone resorption marker, as well as bone formation markers procollagen type I N-terminal peptide (PINP) and osteocalcin (OC) were elevated in AS patients with bridging syndesmophytes [2,19]. Another marker of bone formation, bone-specific alkaline phosphatase (BALP), which is increased during TNFi treatment, may be associated with a simultaneous increase of bone mineral density (BMD) [20,21].…”

Section: Introductionmentioning

confidence: 99%

Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy

Rademacher

Siderius

Gellert

et al. 2022

Seminars in Arthritis and Rheumatism

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Section: Introductionmentioning

confidence: 99%

Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy

Rademacher

Siderius

Gellert

et al. 2022

Seminars in Arthritis and Rheumatism

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“…The systemic measurement may therefore disturb the serological measurement in terms of bone formation. In contrast to the observed pathological changes, most studies found no difference in serum levels of bone formation markers, like osteocalcin, PINP and bone specific ALP, in patients with AS compared with their control groups [226,[229][230][231][232]. However, increased osteocalcin [230] and PINP levels [233] in AS patients, if present, correlate well with the progression of radiographic syndesmophytes and ankylosis ( Table 5).…”

Section: Tissue Turnover Markers In Ankylosing Spondylitismentioning

confidence: 97%

“…CTX-I is elevated in the serum [230] and urine [229] of AS patients, and is associated with radiographic progression [233]. However, serum CTX-I levels remain unaltered after anti-TNFα treatment in these patients [234].…”

Section: Tissue Turnover Markers In Ankylosing Spondylitismentioning

confidence: 99%

Bone phenotypes in rheumatology – there is more to bone than just bone

Thudium

Nielsen

Sardar

et al. 2020

BMC Musculoskelet Disord

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Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change in bone matrix and mineral turnover. While these diseases share a common tissue axis, their manifestations in the area of pathology are highly diverse, ranging from sclerosis to erosion of bone in different regions. The management of these diseases will benefit from a deeper understanding of the local versus systemic effects, the relation to the equilibrium of the bone balance (i.e., bone formation versus bone resorption), and the physiological and pathophysiological phenotypes of the cells involved (e.g., osteoblasts, osteoclasts, osteocytes and chondrocytes). For example, the process of endochondral bone formation in chondrocytes occurs exists during skeletal development and healthy conditions, but also in pathological conditions. This review focuses on the complex molecular and cellular taxonomy of bone in the context of rheumatological diseases that alter bone matrix composition and maintenance, giving rise to different bone turnover phenotypes, and how biomarkers (biochemical markers) can be applied to potentially describe specific bone phenotypic tissue profiles.

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“…[ 1 , 2 ] With rapid progression, AS generally attacks young people, and exhibits poor prognosis when treatments are delayed or inappropriate. [ 3 ] In AS patients, the most common clinical symptom is back pain which is featured by morning stiffness and alleviation after exercises. [ 4 , 5 ] The sign of this disease is acute and chronic inflammations at sacroiliac joint and at the points of tendons and ligaments attaching to the bone.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis

Hui

Qu²

2020

Medicine

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Background: The present study was performed to statistically explore the effect of anthrax toxin receptor 2 (ANTXR2) polymorphism rs4333130 on individual susceptibility to ankylosing spondylitis (AS) using the method of meta-analysis. Methods: All of the eligible reports were retrieved from well-known electronic databases. The strength of the association between ANTXR2 polymorphism rs4333130 and the susceptibility to AS was evaluated using pooled odds ratios (ORs) with 95% confidence intervals (95% CIs). In addition, subgroup analysis was also performed on the basis of ethnicity to further explore specific correlation between our studied polymorphism and the disease risk. Inter-study heterogeneity was detected with Q test, and P < .05 was considered statistically significant. Sensitivity analysis was implemented through removing each of eligible studies and then recalculating overall effects to test the reliability of final estimates. Publication bias among included studies was inspected with both Begg funnel plot and Egger regression test. Results: A total of 6 eligible papers were finally incorporated into the present meta-analysis. In total analysis, ANTXR2 polymorphism rs4333130 was significantly related to decreased risk of AS under CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T and TC versus TT contrasts (OR = 0.35, 95% CI = 0.20–0.64; OR = 0.81, 95% CI = 0.69–0.95; OR = 0.38, 95% CI = 0.21–0.68; OR = 0.89, 95% CI = 0.84–0.95; OR = 0.84, 95% CI = 0.72–0.99). Moreover, a similar effect was also observed in Asian and Caucasian subgroups under corresponding genetic models after stratification analysis based on ethnicity. Conclusion: ANTXR2 polymorphism rs4333130 may function as a protective factor against AS incidence.

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Association between bone turnover markers, clinical variables, spinal syndesmophytes and bone mineral density in Mexican patients with ankylosing spondylitis

Abstract: We observed an increase in OC levels in AS patients with syndesmophytes. BTM levels were associated with the severity of spinal damage. Future longitudinal studies should evaluate whether these BTMs should be included as tools to determine the prognosis and progression of spinal damage.

Cited by 20 publications

References 14 publications

Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy

Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy

Bone phenotypes in rheumatology – there is more to bone than just bone

Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis

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