Association between bone measures and use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers

Holloway‐Kew, Kara L; Betson, Amelia; Anderson, Kara B.; Gaston, James; Kotowicz, Mark A.; Liao, Wan-Hui; Henneberg, Maciej; Pasco, Julie A.

doi:10.1007/s11657-021-01004-6

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Since only five females with a mean age of 58 years were included, the findings cannot be generalized to males and to other age groups. Two patients used antihypertensive medication which is being discussed controversial regarding its influence on bone metabolism, that is, bone mineral density [45][46][47]. Interindividual and site-specific differences found in protein composition and regulation should be verified in larger cohorts, characterizing the oral and general health of these patients with detail.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of human bone from different anatomical sites – A pilot study

Fretwurst

Tritschler²,

Rothweiler

et al. 2022

Proteomics Clinical Apps

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Purpose:The study aim is a comparative proteome-based analysis of different autologous bone entities (alveolar bone [AB], iliac cortical [IC] bone, and iliac spongiosa [IS]) used for alveolar onlay grafting.Experimental Design: Site-matched bone samples of AB, IC, and IS were harvested during alveolar onlay grafting. Proteins were extracted using a detergent-based (sodium dodecyl sulfate) strategy and trypsinized. Proteome analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). MaxQuant was used for peptide-to-spectrum matching, peak detection, and quantitation. Linear models for microarray analysis (LIMMA) were used to detect differentially abundant peptides and proteins.Results: A total of 1730 different proteins were identified across the 15 samples at a false discovery rate of 1%. Partial least-squares discriminant analysis approved segregation of AB, IC, and IS protein profiles. LIMMA statistics highlighted 66 proteins that were more abundant in AB then in IC (vs. 92 proteins were enriched in IC over AB).

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Section: Discussionmentioning

confidence: 99%

Proteomic profiling of human bone from different anatomical sites – A pilot study

Fretwurst

Tritschler²,

Rothweiler

et al. 2022

Proteomics Clinical Apps

View full text Add to dashboard Cite

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“…Different antihypertensive drugs or even the same type of antihyper-tensive drugs has been reported to have different effects on bone health. Angiotensin-converting enzyme inhibitor (ACEI) drugs were a typical example [4].…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System

Zhang

Huo

Chen

et al. 2022

J Renin Angiotensin Aldosterone Syst

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Background. In previous studies, angiotensin-converting enzyme inhibitor (ACEI) use was associated with increased bone loss, while an angiotensin II type I receptor blocker had no effect on bone loss in elder subjects, which suggested that the effect of ACEI on bone loss was not mediated through the classical renin-angiotensin system. In this study, we set to investigate whether the effect of ACEI on bone deterioration was mediated via the kinin-kallikrein system. Methods. Six-month-old male and female spontaneously hypertensive rats were used. The effect of captopril on blood pressure, serum Ang II, and bradykinin concentration was measured in intact rats. Ovariectomy and orchidectomy were performed to establish an osteoporosis model in female and male rats, respectively. Captopril and the bradykinin receptor blocker icatibant (HOE140) were administered after operation for 12 weeks. Serum Ang II and bradykinin concentration, bone turnover markers, bone mineral density (BMD), and bone microarchitecture were evaluated. Femur samples were subjected to a mechanical test. Results. Captopril decreased blood pressure and serum Ang II concentration and increased serum bradykinin concentration in intact rats ( P < 0.05 ). After castration, captopril decreased serum Ang II concentration ( P < 0.05 ); in female rats, icatibant increased serum Ang II concentration ( P < 0.05 ). Captopril increased serum bradykinin concentration ( P < 0.05 ); in male rats, icatibant decreased serum bradykinin concentration ( P < 0.05 ). Captopril increased the rat urine deoxypyridinoline-creatinine ratio (DPD/Cr) and serum osteocalcin concentration ( P < 0.05 ). Icatibant decreased urine DPD/Cr in male rats ( P < 0.05 ) and increased osteocalcin concentration in female rats ( P < 0.05 ). Captopril increased cancellous BMD in castrated hypertensive rats ( P < 0.05 ), and icatibant further increased cancellous BMD ( P < 0.05 ), which was due to the increased trabecular bone number. In mechanical testing, ACEI increased bone strength ( P < 0.05 ), and icatibant further improved it ( P < 0.05 ). Conclusion. ACEI decreased bone deterioration in both male and female hypertensive rats, and the bradykinin receptor blocker further decreased bone deterioration.

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Bone Water: Effects of Drugs on Bone Hydration Status

Ahmed Khan

2023

Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad

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Water is the most crucial nutrient that constitutes roughly 20% of the cortical bone by volume, yet most ignored in health and nutrition areas. Hydration significantly influences the mechanical properties and tissue quality of bone, whereas bone dehydration causes an increase in its elastic modulus. Moreover, the low water content in the trabecular skeleton changes its construction (shrinkage) and leads to a significant alteration in mechanical properties. Numerous internal (a lack of thirst sensation) or external (polypharmacy or chronic consumption of certain drugs) factors cause hypohydration. Unfortunately, frail elderly individuals are more vulnerable to developing dehydration particularly, due to a decrease in the fat-free mass, which contains 73% of total body water. Today, technical advancements have led to an emerging understanding of how bone water changes in various conditions including aging, diabetes, osteoporosis, and osteogenesis imperfecta. Drugs may also change the impression of hypohydration through the increase of water elimination causing diarrhoea, diuresis, or sweat; a decrease in thirst sensation or appetite; or affecting the central thermoregulation mechanism. However, research on the interaction between bone hydration status and drugs/excipients has been insufficient. In the present review, we evaluate studies that focus on the significance of bone hydration and the effects of drugs/excipients on hydration status.

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Association between bone measures and use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers

Cited by 3 publications

References 41 publications

Proteomic profiling of human bone from different anatomical sites – A pilot study

Proteomic profiling of human bone from different anatomical sites – A pilot study

The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System

Bone Water: Effects of Drugs on Bone Hydration Status

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