Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population

Abstract

Vitamin D is a micronutrient that plays a key role in phosphocalcic metabolism. The postmenopausal population presents a risk of deficiency in this vitamin due to hormonal alterations which, in the case of obesity, would be exacerbated. The objective was to assess the status of vitamin D in a postmenopausal population and determine the relationship of 25-hydroxivitamin D [25(OH)D] and its metabolites with anthropometric parameters. The study included 78 healthy postmenopausal women aged from 44 to 76. The nutrient intake assessment was carried out using the 24 h reminder (R24h). 25(OH)D was analyzed using ultra-high-performance liquid chromatography (UHPLC). A total of 80% and 68% of the women studied did not reach sufficient values of 25(OH)D and 25-hydroxivitamin D 3 [25(OH)D 3 ], respectively, which was inversely correlated with Body Mass Index (BMI) (r = −0.25, p = 0.04), hip perimeter (r = −0.26 and r = −0.24, all p < 0.05), arm circumference (r = −0.29, p = 0.01) and fat mass (r = −0.28 and r = −0.26, all p < 0.05). 25(OH)D 3 is the metabolite that contributed most to this association. In conclusion, 25(OH)D 3 levels are related to anthropometric parameters in the postmenopausal women in this study, confirming insufficient status in the majority of the population. Approach strategies are necessary to correct and avoid this risk in order to ensure future quality of life.

Factors Associated with Bone Mineral Density and Bone Resorption Markers in Postmenopausal HIV-Infected Women on Antiretroviral Therapy: A Prospective Cohort Study

“…A large portion of the women included in this study were also classified as overweight according to their BMI. A recent study found that postmenopausal women with a higher BMI (>27 kg/m 2 ) had lower levels of 25(OH)D [ 54 ]. This is similar to the results of our study, as serum 25(OH)D decreased over the observational period.…”

Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level

“…Jansen et al reported that BMI should be considered for better estimation of the loading dose of cholecalciferol needed to treat vitamin D deficiency [ 37 ], but they noted that this does not exclude large interindividual variation in dose response. It is well established that obese people have higher risk for vitamin D deficiency [ 38 , 39 ]; Drincic et al reported that most parsimonious explanations for this is simple dilution of 35-OH-vitD in the larger fat and tissue mass [ 40 ]. They also investigated response to graded cholecalciferol supplementation among obese adults [ 41 ], showing that, in obese patients, the dose of vitamin D should be adjusted considering the body size.…”

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

“…PTH and osteocalcin levels were measured using EIA by colorimetric method (ECLIA, Elecsys 2010 and Modular Analytics E170, Roche Diagnostics, Mannheim, Germany). Vitamin D levels were measured by LC-MS/MS (Acquity UHPLC System I-Class Waters, Milford, USA) [33]. The biochemical values of vitamin D obtained were classified according to the reference values of 25-OH-D in plasma, being sufficiency >30 ng/mL, insufficiency 20-30 ng/mL and deficiency <20 ng/mL for total vitamin D [33].…”

“…Vitamin D levels were measured by LC-MS/MS (Acquity UHPLC System I-Class Waters, Milford, USA) [33]. The biochemical values of vitamin D obtained were classified according to the reference values of 25-OH-D in plasma, being sufficiency >30 ng/mL, insufficiency 20-30 ng/mL and deficiency <20 ng/mL for total vitamin D [33]. The remaining biochemical parameters such as glucose, urea, uric acid, creatinine, triglycerides, total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, total proteins, transferrin, albumin, homocysteine, bilirubin and transaminases levels, were determined in the Analysis Unit at the Virgen de las Nieves Hospital, Granada (ECLIA, Elecsys 2010 and Modular Analytics E170, Roche Diagnostics, Mannheim, Germany).…”