Association between blood lipid profile and urolithiasis: A systematic review and meta‐analysis of observational studies

Abstract

The objective of this study was to pool individual studies regarding the association of blood lipid profiles with urolithiasis to carry out a systematic review and meta-analysis. We searched MEDLINE, PubMed, Embase and Cochrane Library to identify the relevant studies up to November 2017. Studies that met all inclusion criteria were chosen, and a pooled analysis of the odds ratio between urolithiasis and dyslipidemia traits was calculated. A total of 11 observational studies (seven cross-sectional, three cohort, one case-control) with a total of 282 479 participants were examined. The overall pooled analysis of eight studies showed that high triglyceride was associated with increased estimated risk of urolithiasis (odds ratio 1.287, 95% CI 1.073-1.544; P = 0.007). Estimates of the total effect size were consistent in the sensitivity analysis. No evidence of publication bias was detected. The overall pooled analysis of nine studies showed low high-density lipoprotein was weakly associated with increased estimated risk of urolithiasis (odds ratio 1.171, 95% CI 1.010-1.358; P = 0.032). The sensitivity analysis showed conflicting results. No evidence of publication bias was detected. Three studies on the association between any dyslipidemia traits and urolithiasis showed a significant association (odds ratio 1.309, 95% CI 1.202-1.425; P < 0.001). The present meta-analysis showed that patients with higher triglyceride and lower high-density lipoprotein had an increased estimated risk of urolithiasis. A triglyceride-urolithiasis association was found to be more coherent and consistent compared with the high-density lipoprotein-urolithiasis association. Although somewhat contradictory results have been found, the meta-analysis is encouraging for evaluating urolithiasis as a systemic disorder. Further well-designed prospective randomized controlled or cohort studies are necessary to better elucidate the causal association of dyslipidemia and urolithiasis.

Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis

“…Our study reveals that there was a 1.586 -fold increased risk of nephrolithiasis in participants with dyslipidemia. There has been previous meta-analysis that supports the correlation between dyslipidemia and nephrolithiasis ( Besiroglu & Ozbek, 2019 ). Our result was also supported by the fact that consuming statin medications can reduce stone genesis compared to those not consuming statin medications ( Inci et al , 2012 ; Sur et al , 2013 ).…”

STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis

“…Urolithiasis has been linked to a wide variety of comorbidities, such as chronic kidney disease, HTN, DM, metabolic syndrome and CVD. [22][23][24][25] Although these disorders share common risk factors, the multivariate analysis showed that renal function and DM were significantly associated with urolithiasis. In addition, we included Alb and UA in the model that distinguished the Stone group from the Ctrl group.…”

“…The present results suggest that the STEP nomogram can predict a potential “stone former” who develops symptomatic stone colic. Urolithiasis has been linked to a wide variety of comorbidities, such as chronic kidney disease, HTN, DM, metabolic syndrome and CVD . Although these disorders share common risk factors, the multivariate analysis showed that renal function and DM were significantly associated with urolithiasis.…”

Chronic hepatitis B virus infection increases the risk of upper urinary calculi

“…[ 10 ]. The potential risk factors for urinary calculi include metabolic disorders, hypercalcemic disorders, low urine volume, recurrent urinary tract infections, hypertension, obesity, abnormalities of urinary pH, repeated urinary tract infections, and renal tubular acidosis [ 11 – 13 ]. However, some of these risk factors are not always associated with urinary calculi and may vary greatly between men and women.…”