Association between blood levels of lead, blood pressure and risk of diabetes and heart disease in workers

Bener, Abdülbari; Obineche, Enyioma N.; Gillett, Michael P. T.; Pasha, Mazhar; Bishawi, Bassam

doi:10.1007/s004200100231

Cited by 66 publications

(47 citation statements)

References 16 publications

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“…Lead is also considered one of the contributing factors to hypertension (Ghiasvand et al, 2013;Muntner et al, 2003), and blood exposure has been associated with high arterial blood pressure in occupationally exposed workers and in the general population (ATSDR, 2007;Bener et al, 2001;Cheng et al, 2001;Kuno et al, 2013). Participants in our study with moderate elevations of diastolic pressure displayed higher levels of BLL, which is consistent with previous findings.…”

Section: Discussionsupporting

confidence: 94%

Reference Values of Lead in Blood and Related Factors Among Blood Donors in the Western Amazon, Brazil

Freire

Koifman

Fujimoto

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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The aim of this study was to (1) determine the reference value of blood lead levels (BLL) in a sample of blood donors of Rio Branco, the capital city of Acre, in the Western Brazilian Amazon, and (2) explore factors influencing lead (Pb) exposure levels. Between 2010 and 2011, blood samples were collected from universal blood donors attending the Central Hemotherapic Unit in Rio Branco with a total number of 1196. Information on characteristics of 1183 donors was obtained through questionnaires. Blood Pb concentrations were determined by inductively coupled plasma-mass spectrometry with detection limit of 0.003 μg/L. Association between BLL and participant characteristics was examined by linear regression analysis. Reference values of BLL were calculated as the upper limit of the 95% confidence interval of the 95th percentile. Reference values of BLL were 109.5 μg/L for men, 70.7 μg/L for women, 88.9 μg/L for younger individuals (18-29 yr), 115.3 μg/L for older ones (≥30 yr), 94.2 μg/L for nonsmokers, and 164.5 μg/L for smokers. Levels of BLL were significantly higher in males, subjects older than 29 yr, non-whites, smokers, regular consumers of manioc flour, and donors practicing any activity related to paints, ceramics, pottery, fishing, or firearms. Subjects with higher education, higher income, vitamin intake use, and drinkers of bottled water displayed lower BLL. In general, BLL in men and women from Rio Branco were higher than those described in other adult populations. Prevention of exposure of this population to local sources of Pb needs to be addressed.

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Section: Discussionsupporting

confidence: 94%

Reference Values of Lead in Blood and Related Factors Among Blood Donors in the Western Amazon, Brazil

Freire

Koifman

Fujimoto

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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“…These include obesity, hypertension, and other comorbid conditions (10,20). Fourth, environmental conditions, such as dioxin (27,28), lead (29), and polychlorinated biphenyl (30) exposure, may also play a role in the association of adverse neighborhood and housing conditions with development of diabetes.…”

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confidence: 99%

The Effect of Adverse Housing and Neighborhood Conditions on the Development of Diabetes Mellitus among Middle-aged African Americans

Schootman¹,

Andresen²,

Wolinsky³

et al. 2007

American Journal of Epidemiology

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The authors examined the associations of observed neighborhood (block face) and housing conditions with the incidence of diabetes by using data from 644 subjects in the African-American Health Study (St. Louis area, Missouri). They also investigated five mediating pathways (health behavior, psychosocial, health status, access to medical care, and sociodemographic characteristics) if significant associations were identified. The external appearance of the block the subjects lived on and housing conditions were rated as excellent, good, fair, or poor. Subjects reported about neighborhood desirability. Self-reported diabetes was obtained at baseline and 3 years later. Of 644 subjects without self-reported diabetes, 10.3% reported having diabetes at the 3-year follow-up. Every housing condition rated as fair-poor was associated with an increased risk Correspondence to Dr. Mario Schootman, Division of Health Behavior Research, Washington University, 4444 Forest Park Boulevard, Box 8504, St. Louis, MO 63108 (mschootm@im.wustl.edu). For permissions, please e-mail: journals.permissions@oxfordjournals.org.Editor's note: An invited commentary on this article appears on page 388, and the authors' response is published on page 391. Conflict of interest: none declared. HHS Public AccessAuthor manuscript Am J Epidemiol. Author manuscript; available in PMC 2015 July 29. Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript of diabetes, with odds ratios ranging from 2.53 (95% confidence interval: 1.47, 4.34 for physical condition inside the building) to 1.78 (95% confidence interval: 1.03, 3.07 for cleanliness inside the building) in unadjusted analyses. No association was found between any of the block face conditions or perceived neighborhood conditions and incident diabetes. The odds ratios for the five housing conditions were unaffected when adjusted for the mediating pathways. Poor housing conditions appear to be an independent contributor to the risk of incident diabetes in urban, middle-aged African Americans. KeywordsAfrican Americans; aging; diabetes mellitus; housing; questionnaires; residence characteristics Diabetes mellitus is now approaching epidemic proportions (1). In the United States, the prevalence and incidence of diabetes increased dramatically during the past two decades (1) such that diabetes now affects about 20.8 million people or 7 percent of the population (2). The number of individuals with diagnosed diabetes is estimated to triple by the year 2050 (3).African Americans are more likely than Whites to develop diabetes (4). Estimates show that 3.2 million African Americans currently have diabetes (5). The number of African Americans with diabetes is projected to triple by the year 2050, but the number is estimated to only double among Whites (3).While the pathogenesis of diabetes is complex, a number of factors have been identified that increase the risk of the disease. In addition to African-American race, they include increased body mass index, age 45 years or older, physica...

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“…Their deficiency or excess, however, play a significant role in the pathogenesis and progression of numerous diseases, including those associated to metabolic syndrome. Literature reports confirm the possibility of toxic metals such as lead and cadmium to be involved in the development of diabetes [3][4][5][6][7]. Animal experiments confirmed that cadmium exposure results in impaired glucose tolerance by down-regulating GLUT-4 expression in adipocytes as well as necrosis and degeneration of pancreatic B cells, which impairs the synthesis and release of insulin [8,9].…”

Section: Discussionmentioning

confidence: 53%

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Diabetes and Obesity in Opole Voivodship, Poland, During 2000–2002

Bunio

Szyguła

Tubek

et al. 2009

Biol Trace Elem Res

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Environmental factors significantly influence the incidence and course of metabolic syndrome diseases such as diabetes and obesity. The content of elements in rainwater is an indirect indicator of their presence in dust suspended in the air. In this paper we present the relationships between the content of selected elements in rainwater and hospitalization frequencies due to diabetes (E10-E13) and obesity (E66). It was assumed that the hospitalization frequency could be taken as a measure of deterioration of the metabolic process in the course of diabetes and its complications. The observations concerned the population of Opole Voivodeship, Poland (one million inhabitants), distributed in small communities of 44,000 to 151,000 inhabitants during the years 2000-2002. In cases of diabetes E10-E13 for all subjects relevant correlation indicators were found for chromium (r = 0.71), cadmium (r = 0.65), and lead (r = 0.66). Borderline relevance was seen for copper (r = 0.57) and zinc (r = 056). For diabetic men the statistically relevant correlations were chromium (r = 0.79), lead (r = 0.77), cadmium (r = 0.74), copper (r = 0.70), chloride (r = 0.69), zinc (r = 0.68), and iron (r = 0.64). For women the only relevant correlations were chromium (r = 0.62) and cadmium (r = 0.55). No significant correlations were found in obese individuals of both sexes.

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Association between blood levels of lead, blood pressure and risk of diabetes and heart disease in workers

Abstract: The study supports the hypothesis of a positive association between lead exposure, high blood pressure and risk of diabetes and heart disease.

Cited by 66 publications

References 16 publications

Reference Values of Lead in Blood and Related Factors Among Blood Donors in the Western Amazon, Brazil

Reference Values of Lead in Blood and Related Factors Among Blood Donors in the Western Amazon, Brazil

The Effect of Adverse Housing and Neighborhood Conditions on the Development of Diabetes Mellitus among Middle-aged African Americans

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Diabetes and Obesity in Opole Voivodship, Poland, During 2000–2002

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