Association between blood ethylene oxide levels and the risk of cardiovascular diseases in the general population

Zeng, Guowei; Zhang, Qi; Wang, Xiaowei; Wu, Kai

doi:10.1007/s11356-021-15572-0

Cited by 25 publications

(22 citation statements)

References 38 publications

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“…Collectively, our ndings corroborate the ndings of the few previously published studies (crosssectional study) that reported the association between ethylene oxide exposure and cardiovascular disease in the general population (Zeng et al, 2021). Speci cally, in a cross-sectional study of 3,410 participants from the NHANES, the authors found that elevated blood levels of ethylene oxide were independently associated with an increased prevalence of cardiovascular disease in the general population (Zeng et al, 2021). However, there was little evidence of any ethylene oxide relationship to allcause and cardiovascular mortality in a cohort of 18 235 ethylene oxide-exposed workers (Steenland et al, 2004).…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies regarding the cardiotoxicity of ethylene oxide exposure in the general population are sparse. Collectively, our ndings corroborate the ndings of the few previously published studies (crosssectional study) that reported the association between ethylene oxide exposure and cardiovascular disease in the general population (Zeng et al, 2021). Speci cally, in a cross-sectional study of 3,410 participants from the NHANES, the authors found that elevated blood levels of ethylene oxide were independently associated with an increased prevalence of cardiovascular disease in the general population (Zeng et al, 2021).…”

Section: Discussionsupporting

confidence: 90%

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Association Between Blood Ethylene Oxide Levels and The Prevalence of Hypertension

Cao

Wang

et al. 2021

Preprint

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The relationship of blood ethylene oxide levels with hypertension and blood pressure has not been addressed. A total of 5005 participants from the National Health and Nutrition Examination Survey (NHANES) 2013–2016 were enrolled. Hypertension was defined as a mean systolic blood pressure (SBP) of at least 140 mmHg, a mean diastolic blood pressure (DBP) of at least 90 mmHg, or both, and/or the self-reported use of prescription drugs for diagnosed hypertension. Generalized linear regression models and restricted cubic spline plots were performed to explore the associations of ethylene oxide levels with hypertension and blood pressure. The prevalence of hypertension in the study sample was 27.6%. After adjusting for cofounding factors, compared with the lowest quantile, the odds ratios (ORs) with 95% confidence intervals (CIs) of hypertension across the quantiles of ethylene oxide levels were 0.80 (0.63, 1.03), 0.91 (0.71, 1.16), and 1.39 (1.06, 1.82), respectively (P for trend 0.001). Compared with the lowest quantile, the highest quantile of blood ethylene oxide levels was significantly associated with the worst DBP profile by approximately 2.67 mmHg. Blood ethylene oxide levels showed a strong nonlinear and positive association with DBP, while no significant association was observed between blood ethylene oxide levels and SBP. These results provide epidemiological evidence of elevated blood levels of ethylene oxide in relation to a higher prevalence of hypertension and higher DBP. Further study is warranted to address these issues.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Association Between Blood Ethylene Oxide Levels and The Prevalence of Hypertension

Cao

Wang

et al. 2021

Preprint

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“…The potential mechanism behind the vitamin D relationship with the blood concentration of ethylene oxide has not been explored. As noted earlier, a previous epidemiological study observed that an increase in the blood concentration of ethylene oxide was associated with an increased white blood cell count and neutrophils in the general population, and there was a positive correlation between the blood concentration of ethylene oxide and cardiovascular diseases (Zeng et al 2021). These results demonstrated that ethylene oxide may activate the in ammatory response.…”

Section: Subgroup Analysis For the Association Between Serum Vitamin D And Blood Of Oxidementioning

confidence: 59%

“…Red blood cell specimens were processed and stored until shipped to the CDC's National Center for Environmental Health for laboratory testing. Ethylene oxide was detected by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) as described in detail elsewhere (Zeng et al 2021). Undetectable concentrations were substituted with the respective detection limit divided by the square root of two.…”

Section: Ethylene Oxide Exposure Assessmentmentioning

confidence: 99%

“…Recently, ethylene oxide exposure has been associated with increased oxidative stress and health-related disorders in humans (Guo et (Johns et al 2017). In a recent study using data from the National Health and Nutrition Examination Survey (NHANES), the signi cant association of ethylene oxide with blood in ammation parameters was 0.05 *10^9/L per pmol/g Hb of ethylene oxide in the blood for white blood cells (Zeng et al 2021). Since the in uence of vitamin D on in ammation is well recognized (Mangin et al 2014), we hypothesized that an elevated vitamin D level is linked to reduced blood concentrations of ethylene oxide.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency is Associated With Elevated Blood Concentrations of Ethylene Oxide

Chen

Kong

et al. 2021

Preprint

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Ethylene oxide has been associated with increased oxidative stress and related disorders in recent studies, while vitamin D is a widely recognized antioxidant. Whether vitamin D deficiency is related to elevated blood concentrations of ethylene oxide is still unknown. We aimed to explore the relationship between vitamin D deficiency and blood concentrations of ethylene oxide in the general population. A total of 4125 adults who participated in the National Health and Nutrition Examination Survey (NHANES) 2013–2016 were analyzed. Participants were divided into 3 groups: vitamin D sufficiency (≥75.0 nmol/L), insufficiency (50–74.9 nmol/L), and deficiency (<50.0 nmol/L). Adjusted linear and restricted cubic spline regression models were performed to evaluate the associations between vitamin D levels and blood concentrations of ethylene oxide. Compared with participants with vitamin D sufficiency, the adjusted mean ethylene oxide level was approximately 0.08 and 0.23 log2-units higher in the presence of vitamin D insufficiency and vitamin D deficiency (P for trend <0.001). The adjusted percent difference with a 95% confidence interval in ethylene oxide per interquartile range increase in vitamin D was -1.13 (-1.68, -0.57). A restricted cubic spline model demonstrated that vitamin D levels are nonlinearly and inversely associated with blood concentrations of ethylene oxide (P for nonlinearity =0.021). Further research is warranted to understand how vitamin D may have a role in reducing blood concentrations of ethylene oxide.

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Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013–2014

Xue,

Tang,

Ren

et al. 2024

Clin Oral Invest

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Association between blood ethylene oxide levels and the risk of cardiovascular diseases in the general population

Cited by 25 publications

References 38 publications

Association Between Blood Ethylene Oxide Levels and The Prevalence of Hypertension

Association Between Blood Ethylene Oxide Levels and The Prevalence of Hypertension

Vitamin D Deficiency is Associated With Elevated Blood Concentrations of Ethylene Oxide

Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013–2014

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