Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

Abstract

BackgroundWe aimed to investigate the prognostic value of two biomarkers of tissue inflammation, matrix metalloproteinase-dependent degradation of C-reactive protein (CRPM) and connective tissue type I collagen turnover (C1M), on the incidence and progression of radiographic osteoarthritis (OA) in the Rotterdam Study, a prospective cohort. Moreover, the independent effect of these biomarkers with respect to the established biomarkers of OA progression, like urinary type II collagen degradation (uCTX-II) and serum cartilage oligomeric protein (COMP), was evaluated.MethodsSerum levels of C1M, CRPM, COMP and CRP of 1335 participants aged >55 years were measured in fasting serum using ELISA. The commercial ELISA detecting CTX-II was used in urine. Radiographs at baseline and 5-year follow-up were scored for OA stage by Kellgren-Lawrence grade. The associations between progression and incidence of OA and the baseline biomarkers were examined using logistic regression and generalized estimating equations adjusted for age, sex, BMI, and possible other confounders.ResultsThe uCTX-II, COMP, and CRP concentrations were associated with the incidence and progression of OA. Moreover, OA progression was positively associated with CRPM (OR = 1.3, p = 0.01) and CRP (OR = 1.3, p = 0.01) levels with similar effect size as uCTX-II (OR = 1.3, p = 0.01) and COMP (OR = 1.2, p = 0.02). CRPM had prognostic value for progression of OA independent from the uCTX-II and COMP.ConclusionsOur study confirmed the associations between uCTX-II and COMP concentrations and OA progression. Importantly, we showed for the first time that CRPM predicts the risk of OA progression independent of the established biomarkers uCTX-II and COMP.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-016-0976-3) contains supplementary material, which is available to authorized users.

Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

“…This is well in line with a recent review on several related studies [34]. Our findings also concur with previous reports in which the level of CRP is correlated with disease progression in patients with knee OA assessed by X-rays and MRI, and an elevated level is associated with poorer disease outcome [23, 35–38]. However, these findings have not yet attained unanimity [39].…”

Glucose homeostasis influences the risk of incident knee osteoarthritis: Data from the osteoarthritis initiative

“…Among 40 individuals with and without knee osteoarthritis, CRP was associated with radiographic progression over 8 years but not over 5 years . Furthermore, in the Rotterdam study CRP was predictive of incident knee osteoarthritis . Investigators using the Rotterdam study may have detected an association because it is a population‐based sample.…”

“…8 Recently, investigators from the Rotterdam study reported that CRP was not associated with the prevalence of osteoarthritis but was predictive of incident knee osteoarthritis. 9 Inflammation may play a greater role in some individuals with osteoarthritis. For example, 57% of adults with advanced-stage knee or hip osteoarthritis have inflammatory infiltrates in their synovial membrane and these adults have greater concentrations of plasma CRP than other adults with osteoarthritis.…”

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

“…It was shown that levels of CRPM in serum were associated with risk of OA progression in patients with knee and hip OA [94]. …”