Association between B‑<i>Myb</i> proto‑oncogene and the development of malignant tumors (Review)

Jin, Yinlong; Qi, Gangqiao; Chen, Guang; Wang, Chen; Fan, Xiaoyan

doi:10.3892/ol.2021.12427

Cited by 7 publications

(5 citation statements)

References 68 publications

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“…TFs recognize specific DNA sequences to control chromatin and transcription, forming a complex system to guide the genome expression [ 9 ]. With a key role in human physiology, disease and variation, TFs are closely related to the occurrence and development of tumors [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer

Zheng

Lin

et al. 2023

BMC Med Genomics

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Background Breast cancer (BRCA) is the most common malignancy with high morbidity and mortality in women, and transcription factor (TF) is closely related to the occurrence and development of BRCA. This study was designed to identify a prognostic gene signature based on TF family to reveal immune characteristics and prognostic survival of BRCA. Methods In this study, RNA-sequence with corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) and GSE42568. Prognostic differentially expressed transcription factor family genes (TFDEGs) were screened to construct a risk score model, after which BRCA patients were stratified into low-risk and high-risk groups based on their corresponding risk scores. Kaplan–Meier (KM) analysis was applied to evaluate the prognostic implication of risk score model, and a nomogram model was developed and validated with the TCGA and GSE20685. Furthermore, the GSEA revealed pathological processes and signaling pathways enriched in the low-risk and high-risk groups. Finally, analyses regarding levels of immune infiltration, immune checkpoints and chemotactic factors were all completed to investigate the correlation between the risk score and tumor immune microenvironment (TIME). Results A prognostic 9-gene signature based on TFDEGs was selected to establish a risk score model. According to KM analyses, high-risk group witnessed a significantly worse overall survival (OS) than low-risk group in both TCGA-BRCA and GSE20685. Furthermore, the nomogram model proved great possibility in predicting the OS of BRCA patients. As indicted in GSEA analysis, tumor-associated pathological processes and pathways were relatively enriched in high-risk group, and the risk score was negatively correlated with ESTIMATE score, infiltration levels of CD4+ and CD8+T cells, as well as expression levels of immune checkpoints and chemotactic factors. Conclusions The prognostic model based on TFDEGs could distinguish as a novel biomarker for predicting prognosis of BRCA patients; in addition, it may also be utilized to identify potential benefit population from immunotherapy in different TIME and predict potential drug targets.

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Section: Discussionmentioning

confidence: 99%

Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer

Zheng

Lin

et al. 2023

BMC Med Genomics

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“…Several tumor types including cervical cancer show a persistent aberrant activation of NF-κB, and NF-κB activation promotes cancer invasion, metastasis, and chemoresistance [ 28 ]. MYB is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development [ 29 ]. The aberrantly expressed and constitutively active transcription factor AP-1 increases the severity of lesions during cervical carcinogenesis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

Wang

Zheng

et al. 2021

Aging

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“…MYB can be stimulated by external signals via the extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) signalling pathways [11,12]. The dysregulation of MYB was validated to be correlated to the progression of different cancers including breast cancer, colorectal cancer, and leukaemia [13]. Here we set out to demonstrate that MYB functions as a transcription factor of LINC00092 in PTC.…”

Section: Linc00092 Is Downregulated In Ptcmentioning

confidence: 93%

MYB/LINC00092 regulatory axis promotes the progression of papillary thyroid carcinoma

Cheng,

Deng,

2024

Endokrynol Pol

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Long non-coding RNAs (lncRNAs) are composed of over 200 nucleotides, which lack protein coding ability [4]. Accumulative studies have shown that the occurrence and the progression of cancers are associated with dysregulated lncRNAs [5]. Our previous study showed that lncRNA ZFAS1 promotes the metastasis of PTC via regulation of the miR-373-3p/MMP3 axis. In addition, ZFAS1 is a target of transcription factor CREB3, which is also involved in the regulatory program in PTC progression [6]. Our previous results indicate that dysregulated lncRNA and its associated transcription factor may play an important role in the progression of PTC. Recently, numerous studies have suggested that lncRNA LINC00092 may serve as a tumour suppressor in different cancers, including breast cancer [7] and lung cancer [8], whereas the function of LINC00092 in PTC is still unclear. Therefore, it is intriguing to investigate the role of LINC00092 in PTC metastasis and progression.

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Association between B‑Myb proto‑oncogene and the development of malignant tumors (Review)

Cited by 7 publications

References 68 publications

Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer

Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer

Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

MYB/LINC00092 regulatory axis promotes the progression of papillary thyroid carcinoma

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