Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies

Cao, Yiting; Ji, Shuang; Chen, Yujiao; Zhang, Xiaoshuai; Ding, Guoyong; Tang, Fang

doi:10.1016/j.comppsych.2023.152370

Cited by 4 publications

(3 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research by Cullen AE et al . [ 38 ] demonstrated a higher prevalence of inflammatory and autoimmune diseases in individuals with schizophrenia, and both SCZ patients and their families are at an increased risk of developing immune disorders [ 39 ]. Previous study has suggested that immunotherapy targeting antibodies may alleviate schizophrenic symptoms in some cases [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Immune-Related Gene Signature in Schizophrenia

Wu,

Wang,

et al. 2024

Actas Esp Psiquiatr

View full text Add to dashboard Cite

Background: Schizophrenia (SCZ) is a type of psychiatric disorder characterized by multiple symptoms. Our aim is to decipher the relevant mechanisms of immune-related gene signatures in SCZ. Methods: The SCZ dataset and its associated immunoregulatory genes were retrieved using Gene Expression Omnibus (GEO) and single-sample gene set enrichment analysis (ssGSEA). Co-expressed gene modules were determined through weighted gene correlation network analysis (WGCNA). To elucidate the functional characteristics of these clusters, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used. Additionally, gene set enrichment analysis (GSEA) and Gene Set Variation Analysis (GSVA) were conducted to identify enriched pathways for the immune subgroups. A protein-protein interaction (PPI) network analysis was performed to identify core genes relevant to SCZ. Results: A significantly higher immune score was observed in SCZ compared to control samples. Seven distinct gene modules were identified, with genes highlighted in green selected for further analysis. Using the Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method, degrees of immune cell adhesion and accumulation related to 22 different immune cell types were calculated. Significantly enriched bioprocesses concerning the immunoregulatory genes with differential expressions included interferon-beta, IgG binding, and response to interferon-gamma, according to GO and KEGG analyses. Eleven hub genes related to immune infiltration emerged as key players among the three top-ranked GO terms. Conclusions: This study underscores the involvement of immunoregulatory reactions in SCZ development. Eleven immune-related genes (IFITM1 (interferon induced transmembrane protein 1), GBP1 (guanylate binding protein 1), BST2 (bone marrow stromal cell antigen 2), IFITM3 (interferon induced transmembrane protein 3), GBP2 (guanylate binding protein 2), CD44 (CD44 molecule), FCER1G (Fc epsilon receptor Ig), HLA-DRA (major histocompatibility complex, class II, DR alpha), FCGR2A (Fc gamma receptor IIa), IFI16 (interferon gamma inducible protein 16), and FCGR3B (Fc gamma receptor IIIb)) were identified as hub genes, representing potential biomarkers and therapeutic targets associated with the immune response in SCZ patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Immune-Related Gene Signature in Schizophrenia

Wu,

Wang,

et al. 2024

Actas Esp Psiquiatr

View full text Add to dashboard Cite

show abstract

“…A major global health problem is women’s poor access to medical care in some parts of the world [ 7 ], which is especially problematic because women are prone to medical comorbidities not commonly seen in men [ 1 ]. One example of these differences is the high prevalence of autoimmune disease in women compared to men [ 8 , 9 ] and the association of some of these immunologic diseases with schizophrenia [ 8 , 10 ]. Moreover, antipsychotic medications increase the rate of other diseases that occur frequently in women, e.g., osteoporosis, breast cancer, and obesity [ 4 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Monitoring the Effectiveness of Treatment in Women with Schizophrenia: New Specialized Cooperative Approaches

Natividad,

Seeman,

Paolini

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Women with schizophrenia have specific health needs that differ from those of men and that change through successive life stages. We aimed to review the biopsychosocial literature on schizophrenia that addresses clinically important questions related to the treatment of women, including somatic morbi-mortality, hyperprolactinemia, comorbid substance use disorders, social risk factors, and medication effectiveness/safety. Data search terms were as follows: (Morbidity AND mortality) OR hyperprolactinemia OR (“substance use disorders” OR addictions) OR (“social risk factors”) OR (“drug safety” OR prescription) AND women AND schizophrenia. A secondary aim was to describe a method of monitoring and interdisciplinary staff strategies. Schizophrenia patients show an increased risk of premature death from cardiovascular/respiratory disease and cancer compared to the general population. The literature suggests that close liaisons with primary care and the introduction of physical exercise groups reduce comorbidity. Various strategies for lowering prolactin levels diminish the negative long-term effects of hyperprolactinemia. Abstinence programs reduce the risk of victimization and trauma in women. Stigma associated with women who have serious psychiatric illness is often linked to reproductive functions. The safety and effectiveness of antipsychotic drug choice and dose differ between men and women and change over a woman’s life cycle. Monitoring needs to be multidisciplinary, knowledgeable, and regular.

show abstract

“…Concurrently, accumulating evidence from neuroimmunological studies is pointing to the immune system’s potential involvement in SCZ development, an analogy to other major psychiatric conditions [ 7 , 8 ]. While several prominent hypotheses, including immunocytokine-driven inflammation [ 9 ], innate immune-mediated dysfunction in synaptic pruning [ 10 ], and antibody-mediated autoimmunity [ 11 ], have been suggested, these hypotheses were predominantly derived by extrapolating SCZ-like animal models and human genetic association studies/fluid-based molecular biomarker analyses. Since evidence on cellular abnormalities in SCZ remains scarce and somewhat scattered in the literature, this review aims to provide a comprehensive distillation of clinical findings regarding the potential involvement of various immune cell types in SCZ to facilitate the development of a unifying hypothesis of immune dysregulation in this psychiatric illness.…”

Section: Introductionmentioning

confidence: 99%

Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

Nguyen,

Amerio,

Aguglia

et al. 2023

Cells

View full text Add to dashboard Cite

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.

show abstract

Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies

Cited by 4 publications

References 71 publications

Identification of Immune-Related Gene Signature in Schizophrenia

Identification of Immune-Related Gene Signature in Schizophrenia

Monitoring the Effectiveness of Treatment in Women with Schizophrenia: New Specialized Cooperative Approaches

Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

Contact Info

Product

Resources

About