Association between atrial fibrillation, atrial enlargement, and left ventricular geometric remodeling

Seko, Yuta; Kato, Takao; Haruna, Tetsuya; Izumi, Toshiaki; Miyamoto, Shoichi; Nakane, Eisaku; Inoko, Moriaki

doi:10.1038/s41598-018-24875-1

Cited by 111 publications

(91 citation statements)

References 31 publications

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“…These findings suggest an association between AF and WMHs. Moreover, they agree with previous studies reporting an association between left ventricle remodelling and AF [17]. No significant associations were found for brain ventricles volume, WMHs volume and age.…”

Section: Bootstrap Distribution Of Correlation Between Cardiac Paramesupporting

confidence: 92%

Large Scale Cardiovascular Model Personalisation for Mechanistic Analysis of Heart and Brain Interactions

Banus¹,

Lorenzi²,

Cámara³

et al. 2019

Functional Imaging and Modeling of the Heart

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Cerebrovascular diseases have been associated with a variety of heart diseases like heart failure or atrial fibrillation, however the mechanistic relationship between these pathologies is largely unknown. Until now, the study of the underlying heart-brain link has been challenging due to the lack of databases containing data from both organs. Current large data collection initiatives such as the UK Biobank provide us with joint cardiac and brain imaging information for thousands of individuals, and represent a unique opportunity to gain insights about the heart and brain pathophysiology from a systems medicine point of view. Research has focused on standard statistical studies finding correlations in a phenomenological way. We propose a mechanistic analysis of the heart and brain interactions through the personalisation of the parameters of a lumped cardiovascular model under constraints provided by brain-volumetric parameters extracted from imaging, i.e: ventricles or white matter hyperintensities volumes, and clinical information such as age or body surface area. We applied this framework in a cohort of more than 3000 subjects and in a pathological subgroup of 53 subjects diagnosed with atrial fibrillation. Our results show that the use of brain feature constraints helps in improving the parameter estimation in order to identify significant differences associated to specific clinical conditions.

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Section: Bootstrap Distribution Of Correlation Between Cardiac Paramesupporting

confidence: 92%

Large Scale Cardiovascular Model Personalisation for Mechanistic Analysis of Heart and Brain Interactions

Banus¹,

Lorenzi²,

Cámara³

et al. 2019

Functional Imaging and Modeling of the Heart

View full text Add to dashboard Cite

show abstract

“…Structural and functional left atrial (LA) remodeling is usually a consequence of impaired LV function and elevated LV filling pressure. However, LA remodeling seems to begin at an early stage of LV remodeling or LV diastolic dysfunction 22,23 . Katayama et al showed that increased LV mass index and low Hb concentration was independently associated with LA enlargement in patients with normal LV systolic function 24 .…”

Section: Discussionmentioning

confidence: 99%

Impact of Hemoglobin Levels and Their Dynamic Changes on the Risk of Atrial Fibrillation: A Nationwide Population-Based Study

Lim

Choi

Han

et al. 2020

Sci Rep

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Anemia is a risk factor for cardiovascular disease, but its impact on new-onset atrial fibrillation (AF) is unclear. In this study, we investigated the effect of hemoglobin (Hb) levels and their changes on the risk of Af development in the general population of Korea. We retrospectively analyzed a cohort from the Korean National Health Insurance Service database and identified 9,686,314 subjects (49.8% male) without a history of AF, aged ≥40 years, and with Hb levels available for both first (2009-2010) and second (2011-2012) health checkups. These subjects were followed up until 2017 to determine AF development. The presence of anemia (Hb level <13 g/dL in men and <12 g/dL in women) was a significant risk factor for AF development. However, Hb levels showed a U-shaped association with incident AF after adjustment for cardiovascular risk factors. AF incidence was lowest at Hb levels of 14-14.9 g/dL in men and 12-12.9 g/dL in women. Among individuals with Hb levels within normal ranges (13-15.9 g/dL in men and 12-14.9 g/dL in women), both decrease and increase in Hb levels at the second measurement outside the normal ranges showed an elevation of AF risk by 11% and 21% for men and 3% and 36% for women, respectively, compared with those who maintained normal Hb levels. in conclusion, low or high Hb levels are associated with an increased risk of incident Af. this study suggests that maintaining Hb levels within the normal ranges confers a low risk of Af development.Atrial fibrillation (AF) increased the risk of ischemic stroke and death 1,2 . As the population ages, the prevalence of AF increases, which has a significant impact on public health 3,4 . Therefore, it is important to establish a simple health screening method that can identify people at high risk of AF development.Anemia is associated with an increased risk of cardiovascular morbidity and mortality in patients with chronic kidney disease, heart failure, or coronary artery disease 5 . In the general population, anemia is also a risk factor for cardiovascular diseases 6 . Several studies suggest that high hematocrit or hemoglobin (Hb) levels are also associated with cardiovascular outcomes 7-9 . However, the impact of anemia or Hb level on AF development in the general population has not been well understood. In this study, we aimed to investigate the effect of Hb levels and their changes on the risk of AF development in the general population of Korea. (index year). Among them, we excluded 3,192,730 subjects who were less than 40 years of age, were diagnosed with AF or mitral stenosis, have mechanical heart valves, and whose Hb levels were unavailable, or <5 or ≥20 g/dL. Finally, 9,686,314 individuals were included and followed up until 2017. Figure 1 and Supplementary Figure 1 show the detailed study flow.We obtained baseline characteristics of study subjects, including age, sex, body mass index, and comorbidities such as hypertension, diabetes, dyslipidemia, ischemic heart disease, congestive heart failure, stroke, chronic obstructive pulmonary diseas...

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“…99 In a recent study from Japan, this LVH-AF link was found to be strongest in those with eccentric and concentric LVH, less so in CR. 100 Accordingly, those with LVH regression by EKG in the LIFE study had a 12% lower rate of new onset AF for every standard deviation reduction in Cornell EKG product. 101 This decreased rate of LVH and new onset AF corresponded with a decreased rate of stroke in the losartan treated arm of this study, further solidifying the relationship between changes in LVM, AF, and stroke.…”

Section: Stroke and Atrial Fibrillation (Af)mentioning

confidence: 90%

Prognostic Implications of Left Ventricular Hypertrophy

Stewart

Lavie

Shah

et al. 2018

Progress in Cardiovascular Diseases

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Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over recent years, this reliable and relevant variable can often be overlooked. In this paper, we discuss appropriate techniques for accurate analysis, underlying pathophysiology, and the contributions from various risk factors. The prognostic implications of LVH on stroke, serious arrhythmias, and sudden cardiac death are reviewed. Finally, we examine the effect of therapy to reduce LVH and the resultant clinical outcomes.

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Association between atrial fibrillation, atrial enlargement, and left ventricular geometric remodeling

Cited by 111 publications

References 31 publications

Large Scale Cardiovascular Model Personalisation for Mechanistic Analysis of Heart and Brain Interactions

Large Scale Cardiovascular Model Personalisation for Mechanistic Analysis of Heart and Brain Interactions

Impact of Hemoglobin Levels and Their Dynamic Changes on the Risk of Atrial Fibrillation: A Nationwide Population-Based Study

Prognostic Implications of Left Ventricular Hypertrophy

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