Association between Atrial Fibrillation and Three-Year Mortality in Nondiabetic Patients with Acute First-Ever Ischemic Stroke

Chu, Chun-Hsueh; Weng, Wei; Su, Feng-Chieh; Peng, Tsung-I; Chien, Yu-Yi; Wu, Chia-Lun; Lee, Kuang‐Yung; Wei, Yau Huei; Lin, Shun-Wen; Yu, Yifan; Huang, Wen‐Yi

doi:10.1016/j.jstrokecerebrovasdis.2016.07.012

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…Atrial fibrillation was associated with increased mortality in our univariate analysis, with the odds of history of atrial fibrillation over 3 times higher in patients who died within all 3 time points. This is consistent with the results of previous studies, which found that atrial fibrillation increased mortality after IS in hospital [21][22][23], in the short term [24][25][26], in the medium term [26], as well as in the long term [8,24,25,27]. History of heart failure was also associated with higher mortality rates in both univariate and multivariable models.…”

Section: Discussionsupporting

confidence: 92%

Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic

Bryndziar

Šedová

et al. 2021

Cerebrovasc Dis

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Background and Objective: Short- and long-term mortality following ischemic stroke (IS) and their predictors have not been defined in the Czech population, and studies on long-term mortality are largely missing for the populations of Central Europe. Methods: Using the National Register of Hospitalized Patients and the Czech National Mortality Registry, we analyzed data on 1-month, 1-year, and 3-year all-cause mortality for patients admitted with IS to any of the 4 hospitals with a certified stroke unit in Brno, Czech Republic, in 2011. We reviewed discharge summaries and recorded potential factors impacting mortality after the index stroke event. Using univariate and multivariable analyses, we identified predictors of mortality at all 3 time points. Results: In our multivariable model, statin use (odds ratio [OR] 0.095, p < 0.0001), age at stroke (OR 1.03, p = 0.0445), and admission National Institutes of Health Stroke Scale (NIHSS) score (OR 1.16, p < 0.0001) predicted 1-month mortality, while statin use (OR 0.43, p = 0.0004), history of cardiac failure (OR 2.17, p = 0.0137), age at stroke (OR 1.07, p < 0.0001), and admission NIHSS score (OR 1.14, p < 0.0001) predicted 1-year mortality. Statin use (OR 0.54, p = 0.0051), history of cardiac failure (OR 2.13, p = 0.0206), age at stroke (OR 1.07, p < 0.0001), and admission NIHSS score (OR 1.11, p < 0.0001) also predicted 3-year mortality. Conclusions: Our study is the first to report data on short- and long-term mortality rates and their predictors in patients hospitalized with IS in the Czech population. Our results indicate that mortality rates and predictors of mortality are consistent with those reported in studies from other populations throughout the world.

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Section: Discussionsupporting

confidence: 92%

Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic

Bryndziar

Šedová

et al. 2021

Cerebrovasc Dis

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“…In addition, we did not collect post-baseline in AF patients was markedly higher than that of patients without AF (2.0%). The AF patients were more likely be older 19,20 and have increased stroke severity, 14,19 which are factors leading to increased rates of mortality in both heart rate groups. The Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II (RACE II) trial showed that strict heart rate control (<80 beats/min) did not decrease the mortality risk in patients with permanent AF, 21 and this may be another possible reason for the observed lack of effect of high heart rate on mortality rates in patients with AF.…”

Section: Discussionmentioning

confidence: 99%

Resting Heart Rate and In-Hospital Mortality in Acute Ischemic Stroke Patients With and Without Atrial Fibrillation

Han

Zhang

You

et al. 2020

Circ J

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heart rate and mortality are conflicting. One study reported that high heart rate is associated with increased mortality in acute myocardial infarction patients with AF, 16 whereas another study indicated a J-shaped relationship between heart rate and mortality in patients with permanent AF. 17 Currently, there is a paucity of data on the prognostic role of heart rate on outcomes of ischemic stroke patients with a history of AF. The aim of this study was to evaluate the possible association between high heart rate and in-hospital mortality in AIS patients with and without AF. Methods Study Participants From December 2013 to May 2014, patients with AIS or P revious epidemiological and clinical studies demonstrated that high resting heart rate is significantly associated with increased mortality in the general population, as well as in patients with coronary artery disease, heart failure, hypertension, and stroke. 1-9 High resting heart rate is a risk factor for long-term (24 months) and short-term (in-hospital or 3 months) mortality after ischemic stroke, 7-10 as well as hemorrhage stroke. 11 However, most of these studies were restricted to patients experiencing acute ischemic stroke (AIS) or transient ischemic attack (TIA) without a history of atrial fibrillation (AF). 7-11 AF is one of the most important risk factors for ischemic stroke, accounting for 10-25% of all ischemic strokes and associated with high mortality and morbidly. 12-15 Among AF patients, study findings on the relationship between

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“…AF is responsible for 15–20% of all ischaemic stroke events . In addition, after stroke, AF is associated with higher risks of recurrent stroke events, long‐term morbidity, dependence and mortality than are other subtypes of stroke . Therefore, timely identification of patients with AF and appropriate management of these patients after their first‐ever stroke is crucial.…”

Section: Introductionmentioning

confidence: 99%

Delayed diagnosis of atrial fibrillation after first‐ever stroke increases recurrent stroke risk: a 5‐year nationwide follow‐up study

Chou

Chan

et al. 2018

Internal Medicine Journal

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Association between Atrial Fibrillation and Three-Year Mortality in Nondiabetic Patients with Acute First-Ever Ischemic Stroke

Cited by 4 publications

References 52 publications

Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic

Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic

Resting Heart Rate and In-Hospital Mortality in Acute Ischemic Stroke Patients With and Without Atrial Fibrillation

Delayed diagnosis of atrial fibrillation after first‐ever stroke increases recurrent stroke risk: a 5‐year nationwide follow‐up study

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